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Obesity Surgery
Published in: Obesity Surgery 12/2014

01-12-2014 | Original Contributions

Vagal Innervation of Intestine Contributes to Weight Loss After Roux-en-Y Gastric Bypass Surgery in Rats

Authors: Zheng Hao, R. Leigh Townsend, Michael B. Mumphrey, Laurel M. Patterson, Jianping Ye, Hans-Rudolf Berthoud

Published in: Obesity Surgery | Issue 12/2014

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Abstract

Background

It is conceivable that overstimulation of chemo- and mechano-sensors in the Roux and common limbs by uncontrolled influx of undigested nutrients after Roux-en-Y gastric bypass surgery (RYGB) could lead to exaggerated satiety signaling via vagal afferents and contribute to body weight loss. Because previous clinical and preclinical studies using vagotomy came to different conclusions, the aim was to examine the effects of selective and histologically verified celiac branch vagotomy on reduced food intake and body weight loss induced by RYGB.

Methods

Male Sprague–Dawley rats underwent either RYGB + celiac branch vagotomy (RYGB/VgX, n = 15), RYGB + sham celiac branch vagotomy (RYGB/Sham VgX; n = 6), Sham RYGB + celiac branch vagotomy (Sham/VgX; n = 6), or sham RYGB + sham celiac branch vagotomy (Sham/Sham; n = 6), and body weight, body composition, and food choice were monitored for 3 months after intervention.

Results

In rats with RYGB, histologically confirmed celiac branch vagotomy significantly moderated weight loss during the first 40 days after surgery, compared to either sham or failed vagotomy (P < 0.05). In contrast, celiac branch vagotomy slightly, but non-significantly, reduced body weight gain in sham RYGB rats compared to sham/sham rats. Furthermore, the significant food intake suppression during the first 32 days after RYGB (P < 0.05) was also moderated in rats with verified celiac branch vagotomy.

Conclusions

The results suggest that signals carried by vagal afferents from the mid and lower intestines contribute to the early RYGB-induced body weight loss and reduction of food intake.
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Metadata
Title
Vagal Innervation of Intestine Contributes to Weight Loss After Roux-en-Y Gastric Bypass Surgery in Rats
Authors
Zheng Hao
R. Leigh Townsend
Michael B. Mumphrey
Laurel M. Patterson
Jianping Ye
Hans-Rudolf Berthoud
Publication date
01-12-2014
Publisher
Springer US
Published in
Obesity Surgery / Issue 12/2014
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-014-1338-3

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