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Obesity Surgery
Published in: Obesity Surgery 2/2013

01-02-2013 | Clinical Research

Evaluation of the Influence of Whole and Defatted Flaxseed on Satiety, Glucose, and Leptin Levels of Women in the Late Postoperative Stage of Bariatric Surgery

Authors: Larissa Cohen, Junia Meira, Gigliane Menegati Cosendey, Aline Fonseca Pereira de Souza, Fernanda Mattos, João Régis Ivar Carneiro, Eliane Lopes Rosado

Published in: Obesity Surgery | Issue 2/2013

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Abstract

Background

Satiety decline is one of the factors that are involved in weight regain in the postoperative period of bariatric surgery. Nutrients such as long-chain n-3 polyunsaturated fatty acid and fibers could assist in food intake control by increasing satiety. Flaxseed is a source of these nutrients, and its consumption could help with possible glycemic control and increased satiety. The aim of this study was to evaluate the influence of whole flaxseed and defatted flaxseed on satiety, postprandial blood glucose, and leptin in post-bariatric women.

Methods

A single-blind crossover and randomized study was performed with 18 women in the late postoperative of Roux-en-Y gastric bypass (RYGBP). All women received three test meals containing whole flaxseed, defatted flaxseed, and placebo with 1 week of washout. Satiety was evaluated by a Visual Analog Scale during the fasting period; immediately after ingestion; and 60, 120, and 180 min after meals.

Results

There was no difference between test meals for the variables of hunger, satisfaction, fullness, and desire to eat. The basal and postprandial glucose and leptin levels did not differ between the test meals. The intake of defatted flaxseed and placebo muffins resulted in reduced postprandial blood glucose. Postprandial leptin was higher than the baseline (p = 0.02); however, only defatted flaxseed showed increased postprandial leptin levels (p = 0.044).

Conclusions

Whole flaxseed and defatted flaxseed did not promote satiety in women in the late postoperative of RYGBP. However, the test meals with a lower fat content increased the serum leptin levels.
Literature
1.
Sarwer DB, Dilks R, West-Smith L. Dietary intake and eating behavior after bariatric surgery: threats to weight loss maintenance and strategies for success. Surg Obes Relat Dis. 2011;5:644–51.CrossRef
2.
Sjöström L, Narbro K, Sjöström CD, et al. Swedish Obese Subjects Study. Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med. 2007;357(8):741–52.PubMedCrossRef
3.
Brolin RE. Weight gain after short- and long-limb gastric bypass in patients followed for longer than 10 years. Ann Surg. 2007;246(1):163–4.PubMedCrossRef
4.
Magro DO, Geloneze B, Delfini, et al. Long-term weight regain after gastric bypass: a 5-year prospective study. Obes Surg. 2008;18:648–51.PubMedCrossRef
5.
Dockray G. Gut endocrine secretions and their relevance to satiety. Curr Opin Pharmacol. 2004;4:557–60.PubMedCrossRef
6.
Cummings DE. Ghrelin and the short- and long-term regulation of appetite and body weight. Physiol Behav. 2006;89:71–84.PubMedCrossRef
7.
Zhang JV, Ren P-G, Avsian-Kretchmer O, et al. Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin’s effects on food intake. Science. 2005;310:996–9.PubMedCrossRef
8.
Scopinaro N, Gianetta E, Friedman D. Biliopancreatic diversion for obesity. Probl Gen Surg. 1992;9:362–79.
9.
Oomah BD, Mazza G. Flaxseed proteins—a review. Food Chem. 1993;48(2):109–14.CrossRef
10.
Dodin S, Cunnane SC, Mâsse B, et al. Flaxseed on cardiovascular disease markers in healthy menopausal women: a randomized, double-blind, placebo-controlled trial. Nutrition. 2008;24(1):23–30.PubMedCrossRef
11.
Dahl W, Lockert E, Cammer A, et al. Effects of flaxseed fiber on laxation and glycemic response in healthy volunteers. J Med Food. 2005;8(4):508–11.PubMedCrossRef
12.
Rosado EL, Monteiro JB, Chaia V, et al. Efecto de la leptina en el tratamiento de la obesidade e influencia de la dieta en la secreción y acción de la hormona. Nutr Hosp. 2006;21:686–93.PubMed
13.
American Dietetic Association (ADA). Position of the American Dietetic Association: Health Implications of dietary fiber. J Am Diet Assoc. 1993;93(12):1446–7.CrossRef
14.
TACO (Tabela brasileira de composição de alimentos)/NEPA-UNICAMP—Versão II 2. ed.: Campinas, SP: NEPA-UNICAMP; 2006. p 113.
15.
FAO (Food and Agriculture Organization)/WHO (World Health Organization)/UNU (United Nations University). Energy and Protein Requirements. WHO Technical Report Series, n. 724, Geneva, 1985.
16.
DIETPRO 5i technology for nutrition. Version 5i. Viçosa: A.S. Sistemas, 2008. 1 CD-ROM.
17.
Lott JA, Turner K. Evaluation of Trinder’s glucose oxidase method for measuring glucose in serum and urine. Clin Chem. 1975;21(12):1754–60.PubMed
18.
Kostner GM, Avogaro P, Bon GB, et al. Determination of high-density lipoproteins screening methods compared. Clin Chem. 1979;25:939–42.PubMed
19.
McGowan MW, Artiss JD, Strandbergh DR, et al. A peroxidase coupled method for the colorimetric determination of serum triglycerides. Clin Chem. 1983;29:538–42.PubMed
20.
Friedwald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18:499–502.
21.
World Health Organization (WHO). Measuring obesity-classification and description of anthropometric data. Report of a WHO Regional Office Consultation on the Epidemiology of Obesity. Copenhagen, Denmark: WHO Regional Office for Europe, Nutrition Unit. (Document EUR/ICP/NUT 125), 1988.
22.
Deurenberg P, Weststrate JA, Paymans I, et al. Factors affecting bioelectrical impedance measurements in humans. Eur J Clin Nutr. 1988;42:1017–22.PubMed
23.
Consenso Latino Americano de Obesidade. Arq Bras Endocrinol 1999; 43: 21–67.
24.
Flint A, Raben A, Blundell JE, et al. Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies. Int J Obes. 2000;24:38–48.CrossRef
25.
Food and Nutrition Board; Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids (MacroNutrientes). The National Academies Press, 2005. 936p. apud DOLINSKY, M. Manual Dietético para Profissionais. 2.ed. São Paulo: Roca, 2008.
26.
Ribeiro AG, Faintuch J, Dias MCG, et al. Euglycemia and normolipidemia after anti-obesity gastric bypass. Nutr Hosp. 2009;24(1):32–9.PubMed
27.
Sposito AC, Caramelli B, Fonseca FAH, et al. IV Diretriz brasileira sobre dislipidemias e prevenção da aterosclerose. Departamento de Aterosclerose da Sociedade Brasileira de Cardiologia. Arq Bras Cardiol. 2007;88:S1.CrossRef
28.
Bavaresco M, Paganini S, Lima TP, et al. Nutritional course of patients submitted to bariatric surgery. Obes Surg. 2010;20:716–21.PubMedCrossRef
29.
Brolin RE, Robertson LB, Kenler HA, et al. Weight loss and dietary intake after vertical banded gastroplasty and Roux-en-Y gastric bypass. Ann Surg. 1994;220:782–90.PubMedCrossRef
30.
Sarwer DB, Wadden TA, Moore RH, et al. Preoperative eating behavior, postoperative dietary adherence and weight loss following gastric bypass surgery. Surg Obes Relat Dis. 2008;5:640–6.CrossRef
31.
Hermsdorff HHM, Volp ACP, Bressan J. O perfil de macronutrientes influencia a termogênese induzida pela dieta e a ingestão calórica. Arch Latinoam Nutr. 2007;57(1):33–42.PubMed
32.
Kratz M, Callahan HS, Yang PY, et al. Dietary n-3-polyunsaturated fatty acids and energy balance in overweight or moderately obese men and women: a randomized controlled trial. Nutr Metab (Lond). 2009;6:24–31.CrossRef
33.
Casas-Agustench P, López-Uriarte P, Bulló M, et al. Acute effects of three high-fat meals with different fat saturations on energy expenditure, substrate oxidation and satiety. Clin Nutr. 2009;28(1):39–45.PubMedCrossRef
34.
Strik CM, Lithander FE, McGill AT et al. No evidence of differential effects of SFA, MUFA or PUFA on post-ingestive satiety and energy intake: a randomised trial of fatty acid saturation. Nutrition Journal 2010; 9:24 [Epub ahead of print].
35.
Lawton CL, Delargy HJ, Brockman J, et al. The degree of saturation of fatty acids influences post-ingestive satiety. Br J Nutr. 2000;83(5):473–82.PubMed
36.
Burton-Freeman B, Davis PA, Schneeman BO. Interaction of fat availability and sex on postprandial satiety and cholecystokinin after mixed-food meals. Am J Clin Nutr. 2004;80:1207–14.PubMed
37.
Kristensen M, Jensen MG. Dietary fibres in the regulation of appetite and food intake. Importance of viscosity. Appetite. 2011;56:65–70.PubMedCrossRef
38.
39.
Touyarou P, Sulmont-Rosse C, Issanchou S, et al. Influence of substrate oxidation on the reward system, no role of dietary fibre. Appetite. 2011;57:134–41.PubMedCrossRef
40.
Willis HJ, Thomas W, Eldridge AL, et al. Increasing doses of fiber do not influence short-term satiety or food intake and are inconsistently linked to gut hormone levels. Food Nutr Res. 2010;54:5135. doi:10.​3402/​fnr.​v54i0.​5135.
41.
Levine AS, Tallman JR, Grace MK, et al. Effect of breakfast cereals on short-term food intake. Am J Clin Nutr. 1989;50(6):1303–7.PubMed
42.
43.
Korner J, Inabnet W, Febres G, et al. Prospective study of gut hormone and metabolic changes after adjustable gastric banding and Roux-en-Y gastric bypass. Int J Obes (Lond). 2009;33(7):786–95.CrossRef
44.
Laferrere B, Teixeira J, McGinty J, et al. Effect of weight loss by gastric bypass surgery vs. hypocaloric diet on glucose and incretin levels in patients with type 2 diabetes. J Clin Endocrinol Metab. 2008;93:2479–85.PubMedCrossRef
45.
Radic R, Nikolic V, Karner I, et al. Circadian rhythm of blood leptin in obese and non-obese people. Coll Antropol. 2003;27:555–61.PubMed
46.
Wong ML, Licinio J, Yildiz BO, et al. Simultaneous and continuous 24-hour plasma and cerebrospinal fluid leptin measurements: dissociation of concentrations in central and peripheral compartments. J Clin Endocrinol Metab. 2004;89:258–65.PubMedCrossRef
47.
Hilton LK, Loucks AB. Low energy availability, not exercise stress, supresses the diurnal rhythm of leptin in healthy young women. Am J Physiol Endocrinol Metab. 2000;278:E43–9.PubMed
48.
Sobhani I, Bado A, Vissuzaine C, et al. Leptin secretion and leptin receptor in the human stomach. Gut. 2000;47:178–83.PubMedCrossRef
49.
Picó C, Oliver P, Sanchez J, et al. Gastric leptin: a putative role in the shortterm regulation of food intake. Br J Nutr. 2003;90:735–41.PubMedCrossRef
50.
Sánchez J, Cladera MM, Llopis M, et al. The different satiating capacity of CHO and fats can be mediated by different effects on leptin and ghrelin systems. Behav Brain Res. 2010;213(2):183–8.PubMedCrossRef
51.
Ainslie DA, Proietto J, Fam BC, et al. Short-term, high-fat diets lower circulating leptin concentrations in rats. Am J Clin Nutr. 2000;71:438–42.PubMed
52.
Cabrera EJ, Valezi AC, Delfino VDA, et al. Reduction in plasma levels of inflammatory and oxidative stress indicators after Roux-en-Y gastric bypass. Obes Surg. 2010;20:42–9.CrossRef
53.
Awad AB, Chattopadhyay JP. Effect of dietary saturated fatty acids on hormone-sensitive lipolysis in rat adipocytes. J Nutr. 1986;116:1088–94.PubMed
54.
Storlein L, Kraegen EW, Chisholm DJ, et al. Fish oil prevents insulin resistance induced by high-fat feeding in rats. Science. 1987;237:885–8.CrossRef
55.
Tuomilehto J. A glucose tolerance test is important for clinical practice. Diabetes Care. 2002;25:1880–2.PubMedCrossRef
56.
Carvalheira JBC, Torsoni MA, Ueno M, et al. Cross-talk between the insulin and leptin signaling systems in rat hypothalamus. Obes Res. 2005;13:48–57.PubMedCrossRef
57.
Krog-Mikkelsen I, Sloth B, Dimitrov D, et al. A low glycemic index diet does not affect postprandial energy metabolism but decreases postprandial insulinemia and increases fullness ratings in healthy women. J Nutr. 2011;141:1679–84.PubMedCrossRef
Metadata
Title
Evaluation of the Influence of Whole and Defatted Flaxseed on Satiety, Glucose, and Leptin Levels of Women in the Late Postoperative Stage of Bariatric Surgery
Authors
Larissa Cohen
Junia Meira
Gigliane Menegati Cosendey
Aline Fonseca Pereira de Souza
Fernanda Mattos
João Régis Ivar Carneiro
Eliane Lopes Rosado
Publication date
01-02-2013
Publisher
Springer-Verlag
Published in
Obesity Surgery / Issue 2/2013
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-012-0733-x

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