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Obesity Surgery
Published in: Obesity Surgery 11/2012

01-11-2012 | Clinical Research

Improvement of Atherosclerotic Markers in Non-diabetic Patients After Bariatric Surgery

Authors: Mohamed Hassan Saleh, Marcelo Chiara Bertolami, Jorge Eduardo Assef, Mohamed Ibrahim Taha, Wilson de Freitas Jr., Ana Claudia Gomes Petisco, Rodrigo Bellio Mattos Barretto, David Costa Le Bihan, Jose Eduardo Martins Barbosa, Carlos Alberto de Jesus, Amanda Guerra Moraes Rego Sousa

Published in: Obesity Surgery | Issue 11/2012

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Abstract

Background

The objective of this study was to assess the impact of bariatric surgery performed in extremely obese non-diabetic subjects on the following parameters: endothelial function, inflammatory processes (assessed by high-sensitivity C-reactive protein [hs-CRP]), carotid artery intima-media thickness (CIMT), and glucose and lipid profiles.

Methods

Forty-seven obese individuals with body mass index >40 kg/m2 underwent bariatric surgery and returned for post-procedure assessment between 6 and 19 months after surgery. Ninety-three percent of patients were female. Their age ranged from 18 to 65 (mean 41) years old at baseline. Baseline was defined as the maximum of 30 days before surgery. Before and after surgery, all patients were subjected to a brachial artery ultrasound examination to evaluate endothelial-dependent dilation, CIMT by ultrasound, and laboratory analyses including glucose, lipid and inflammatory profiles were performed.

Results

Subjects lost an average of 33 % of their original weight (p < 0.001). Flow-mediated dilation showed significant improvement after surgery from 7.4 % to 18.9 % (p < 0.001) on average. There was regression of CIMT, with the median being reduced from 0.8 to 0.5 mm (p < 0.001). The median Hs-CRP reduced from 0.83 to 0.18 mg/dl (p < 0.001), while glucose and lipid profiles were also improved after surgery.

Conclusions

This study shows that severely obese, non-diabetic patients who had pronounced weight loss after bariatric surgery had an overall improvement in brachial flow-mediated dilation, CIMT, high-sensitivity CRP, and glucose and lipid metabolism. The best responses of the brachial flow-mediated dilation after surgery were observed in non-smokers and in younger subjects.
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Metadata
Title
Improvement of Atherosclerotic Markers in Non-diabetic Patients After Bariatric Surgery
Authors
Mohamed Hassan Saleh
Marcelo Chiara Bertolami
Jorge Eduardo Assef
Mohamed Ibrahim Taha
Wilson de Freitas Jr.
Ana Claudia Gomes Petisco
Rodrigo Bellio Mattos Barretto
David Costa Le Bihan
Jose Eduardo Martins Barbosa
Carlos Alberto de Jesus
Amanda Guerra Moraes Rego Sousa
Publication date
01-11-2012
Publisher
Springer-Verlag
Published in
Obesity Surgery / Issue 11/2012
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-012-0706-0

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