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Obesity Surgery
Published in: Obesity Surgery 11/2011

01-11-2011 | Animal Research

A Comparative Study of Gastric Banding and Sleeve Gastrectomy in an Obese Diabetic Rat Model

Authors: Takashi Masuda, Masayuki Ohta, Teijiro Hirashita, Yuichiro Kawano, Hidetoshi Eguchi, Kazuhiro Yada, Yukio Iwashita, Seigo Kitano

Published in: Obesity Surgery | Issue 11/2011

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Abstract

Background

Laparoscopic sleeve gastrectomy (SG) is now a typical restrictive bariatric procedure. The aim of this study was to evaluate the efficacy of SG in comparison with gastric banding (GB) in an obese diabetic rat model.

Methods

Forty-five male Zucker diabetic fatty rats were divided into three groups: sham-operated (SO) control, GB, and SG. The rats were followed for 6 weeks after surgery, and their body weight change, cumulative food intake, metabolic parameters, plasma levels of ghrelin, glucagon-like peptide-1 and adiponectin, oral glucose tolerance test (OGTT), insulin tolerance test (ITT), and gastric emptying rate were measured.

Results

The GB and SG groups showed significant decreases in weight, cumulative intake, and metabolic parameters and significant improvement of OGTT and ITT results compared with the SO group. There were no significant differences in weight and cumulative food intake between the groups. However, the SG group showed significantly higher gastric emptying rate and plasma level of adiponectin and lower plasma levels of free fatty acid, total cholesterol, and ghrelin compared with the GB group. Furthermore, the SG group showed improvement of OGTT and ITT results in comparison with the GB group.

Conclusions

In obese diabetic rats, SG may improve glucose and lipid metabolism compared with GB, although there was no significant difference in the effect on body weight loss between the two procedures. The hormonal and digestive changes induced by SG may have relevance to the effects on metabolism.
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Metadata
Title
A Comparative Study of Gastric Banding and Sleeve Gastrectomy in an Obese Diabetic Rat Model
Authors
Takashi Masuda
Masayuki Ohta
Teijiro Hirashita
Yuichiro Kawano
Hidetoshi Eguchi
Kazuhiro Yada
Yukio Iwashita
Seigo Kitano
Publication date
01-11-2011
Publisher
Springer-Verlag
Published in
Obesity Surgery / Issue 11/2011
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-011-0512-0

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