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Obesity Surgery
Published in: Obesity Surgery 2/2010

01-02-2010 | Research Article

Influence of G308A Polymorphism of Tumor Necrosis Factor Alpha Gene on Surgical Results of Biliopancreatic Diversion

Authors: D. A de Luis, D. Pacheco, R. Aller, M. González Sagrado, O. Izaola, M. C. Terroba, L. Cuellar, R. Conde, T. Martin

Published in: Obesity Surgery | Issue 2/2010

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Abstract

Background

Bariatric surgery is the most effective long-term treatment for morbid obesity, reducing obesity-associated comorbidities. The purpose of the present study was to evaluate G308A polymorphism of the tumor necrosis factor (TNF) alpha gene on outcomes 1 year after biliopancreatic diversion.

Methods

A sample of 41 morbidly obese patients (body mass index > 40 kg/m2) were operated on. Weight, fat mass, blood pressure, creatinine, uric acid, basal glucose, triacylglycerols, total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol were measured at basal visit and at each visit. Adipocytokines were measured at basal time and 12 months after surgery. The frequency of patients with diabetes mellitus, hypertension, and hyperlipidemia was recorded at each visit.

Results

Thirty-two patients (78%) had genotype G308G [wild-type group and nine patients (22%) with G308A genotype (mutant-type group)]. Genotype A308A was not detected. In the wild group, body mass index, weight, uric acid, glucose, total cholesterol, low-density lipoprotein cholesterol, triacylglycerol, leptin, and systolic blood pressure decreased. In the mutant group, the same parameters improved. Adiponectin levels increased after surgery in both genotypes. Initial weight percent loss at 1 year of follow up was similar in both groups (32.2% vs 28.6%; ns).

Conclusion

The present study demonstrates that the G308A polymorphism in the TNF-alpha gene is not related to clinical outcomes after bariatric surgery.
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Metadata
Title
Influence of G308A Polymorphism of Tumor Necrosis Factor Alpha Gene on Surgical Results of Biliopancreatic Diversion
Authors
D. A de Luis
D. Pacheco
R. Aller
M. González Sagrado
O. Izaola
M. C. Terroba
L. Cuellar
R. Conde
T. Martin
Publication date
01-02-2010
Publisher
Springer-Verlag
Published in
Obesity Surgery / Issue 2/2010
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-008-9591-y

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