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Obesity Surgery
Published in: Obesity Surgery 9/2008

01-09-2008 | Research Article

Pregnancy in Formerly Type 2 Diabetes Obese Women Following Biliopancreatic Diversion for Obesity

Authors: Gian Franco Adami, Federica Murelli, Lucia Briatore, Nicola Scopinaro

Published in: Obesity Surgery | Issue 9/2008

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Abstract

Background

This study describes the pregnancy of previously obese women with type 2 diabetic who reduced body weight and normalized serum glucose level following biliopancreatic diversion (BPD) for obesity.

Methods

A subset of ten women who had type 2 diabetes prior to BPD and who developed pregnancy after the operation was retrospectively identified.

Results

All pregnancies were completely normal, and serum glucose levels remained within the physiological range throughout all the pregnancy. These post-diabetic women delivered 13 infants in good health with a normal birth weight and no case of macrosomia.

Conclusions

These data are a clinical confirmation of the post-BPD improvement of beta-cell response to increased functional demand in obese patients with preoperative type 2 diabetes.
Literature
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Catalano PM, Huston L, Amini SB, et al. Longitudinal changes in glucose metabolism during pregnancy in obese women with normal glucose tolerance and gestational diabetes mellitus. Am J Obstet Gynecol. 1999;180:903–16.PubMedCrossRef
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Dunne F, Brydon P, Smith K, et al. Pregnancy in women with Type 2 diabetes: 12 years outcome data 1990–2002. Diabet Med. 2003;20:734–8.PubMedCrossRef
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Walkinshaw SA. Pregnancy in women with pre-existing diabetes: management issues. Semin Fetal Neonatal Med. 2005;10:307–15.PubMedCrossRef
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Pedersen J. The pregnant diabetic and her newborn—Problems and management. Copenhagen: Munksgaard; 1977.
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Scopinaro N, Adami GF, Marinari UM, et al. Biliopancreatic diversion. World J Surg. 1999;22:936–46.CrossRef
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Friedman D, Cuneo S, Valenzano M, et al. Pregnancies in an 18-year follow-up after biliopancreatic diversion. Obes Surg. 1995;5:308–13.PubMedCrossRef
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Greco AV, Mingrone G, Giancaterini A, et al. Insulin resistance in morbid obesity: reversal with intramyocellular fat depletion. Diabetes. 2002;51:144–51.PubMedCrossRef
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Polyzogopoulou EV, Kalfarentzos F, Vagenakis AG, et al. Restoration of euglycemia and normal acute insulin response to glucose in obese subjects with type 2 diabetes following bariatric surgery. Diabetes. 2003;52:1098–103.PubMedCrossRef
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Scopinaro N, Marinari GM, Camerini GB, et al. Specific effects of biliopancreatic diversion on the major components of metabolic syndrome: a long-term follow-up study. Diabetes Care. 2005;28:2406–11.PubMedCrossRef
Metadata
Title
Pregnancy in Formerly Type 2 Diabetes Obese Women Following Biliopancreatic Diversion for Obesity
Authors
Gian Franco Adami
Federica Murelli
Lucia Briatore
Nicola Scopinaro
Publication date
01-09-2008
Publisher
Springer-Verlag
Published in
Obesity Surgery / Issue 9/2008
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-008-9544-5

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