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Obesity Surgery
Published in: Obesity Surgery 12/2008

01-12-2008 | Research Article

Preoperative Gender Differences in Pulmonary Gas Exchange in Morbidly Obese Subjects

Authors: Gerald S. Zavorsky, Nicolas V. Christou, Do Jun Kim, Franco Carli, Nancy E. Mayo

Published in: Obesity Surgery | Issue 12/2008

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Abstract

Background

Morbidly obese men may have poorer pulmonary gas exchange compared to morbidly obese women (see Zavorsky et al., Chest 131:362–367, 2007). The purpose was to compare pulmonary gas exchange in morbidly obese men and women at rest and throughout exercise.

Methods

Twenty-five women (age = 38 ± 10 years, 164 ± 7 cm, body mass index or BMI = 51 ± 7 kg/m2, peak oxygen consumption or \(\mathop V\limits^ \cdot \)O2peak = 2.0 ± 0.4 l/min) and 17 men (age = 43 ± 9 years, 178 ± 7 cm, BMI = 50 ± 10 kg/m2, \(\mathop V\limits^ \cdot \)O2peak = 2.6 ± 0.8 l/min) were recruited to perform a graded exercise test on a cycle ergometer with temperature-corrected arterial blood-gas samples taken at rest and every minute of exercise, including peak exercise.

Results

At rest, women were 98% predicted for pulmonary diffusion compared to 88% predicted in men. At rest, women had better pulmonary gas exchange compared to the men which was related to women having a lower waist-to-hip ratio (WHR; p < 0.01). Only 20% of the subjects had an excessive alveolar-to-arterial oxygen partial pressure difference (≥25 mmHg) at peak exercise, but 75% of the subjects showed inadequate compensatory hyperventilation at peak exercise (arterial carbon dioxide pressure >35 mmHg), and both were not different between genders.

Conclusion

At rest, morbidly obese men have poorer pulmonary gas exchange and pulmonary diffusion compared to morbidly obese women. The better gas exchange in women is related to the lower WHR in the women. During exercise, few subjects showed disturbances in pulmonary gas exchange despite demonstrating poor compensatory hyperventilation at peak exercise.

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Metadata
Title
Preoperative Gender Differences in Pulmonary Gas Exchange in Morbidly Obese Subjects
Authors
Gerald S. Zavorsky
Nicolas V. Christou
Do Jun Kim
Franco Carli
Nancy E. Mayo
Publication date
01-12-2008
Publisher
Springer-Verlag
Published in
Obesity Surgery / Issue 12/2008
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-008-9527-6

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