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Obesity Surgery
Published in: Obesity Surgery 10/2008

01-10-2008 | Research Article

Gastroesophageal Reflux Disease in Morbid Obesity: The Effect of Roux-en-Y Gastric Bypass

Authors: Mariel A. Mejía-Rivas, Alejandro Herrera-López, Jorge Hernández-Calleros, Miguel F. Herrera, Miguel A. Valdovinos

Published in: Obesity Surgery | Issue 10/2008

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Abstract

Background

Gastroesophageal reflux disease (GERD) is a common condition in obesity. The impact of Roux-en-Y gastric bypass (RYGBP) on GERD is poorly known. We studied the effect of the RYGBP on GERD in patients with morbid obesity (MO).

Methods

Twenty consecutive patients with MO (BMI > 40 kg/m2) were studied before and 6 months after RYGBP. GERD symptoms were evaluated with Carlsson–Dent questionnaire (CDQ). All the patients underwent esophageal manometry and ambulatory 24-h pH-metry. Chi-square test was used to compare categorical variables, and Wilcoxon test was used for numerical variables. A p value under 0.05 was considered significant.

Results

There were 16 women (80%) and 4 men (20%) with mean age 38.9 ± 6.9 years included in this study. BMI was 48.5 ± 6.2 kg/m2 and 33.2 ± 4.5 kg/m2 before and after RYGBP, respectively. Mean weight reduction was 42.5 ± 9.7 kg (p < 0.001). Reflux symptoms measured by CDQ and esophageal acid exposure improved significantly after RYGBP. The percentage of time of pH < 4 was 10.7 ± 6.7 before and 1.6 ± 1.2 after the surgical procedure (p < 0.001). LES basal pressure before and after the RYGBP was 18 ± 11 and 20.1 ± 5.6 mmHg (p = 0.372), and the esophageal body amplitude was 104.2 ± 47.2 and 75.1 ± 36.2 mmHg, respectively (p = 0.005).

Conclusion

RYGBP improves GERD symptoms and reduces esophageal acid exposure in patients with MO.
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Metadata
Title
Gastroesophageal Reflux Disease in Morbid Obesity: The Effect of Roux-en-Y Gastric Bypass
Authors
Mariel A. Mejía-Rivas
Alejandro Herrera-López
Jorge Hernández-Calleros
Miguel F. Herrera
Miguel A. Valdovinos
Publication date
01-10-2008
Publisher
Springer-Verlag
Published in
Obesity Surgery / Issue 10/2008
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-008-9474-2

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