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Obesity Surgery
Published in: Obesity Surgery 4/2008

01-04-2008 | Research Article

Gastric Bypass Surgery Causes Body Weight Loss Without Reducing Food Intake in Rats

Authors: Marianne W. Furnes, Karin Tømmerås, Carl-Jørgen Arum, Chun-Mei Zhao, Duan Chen

Published in: Obesity Surgery | Issue 4/2008

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Abstract

Background

It is a common dogma that gastric bypass (GB) induces early satiety and consequent reductions in food intake and nutrient absorption. The aim of the present study was to analyze feeding behavioral and metabolic changes in rats after GB.

Methods

Male Sprague–Dawley rats at the ages of 23 and 42 weeks were placed in metabolic cages connected with a comprehensive laboratory animal monitoring system. At the age of 48 weeks they were subjected to either GB or sham operation, and then placed in metabolic cages at 51 and 62 weeks (or 3 and 14 weeks postoperatively).

Results

GB rats lost 20% of the body weight within 2–3 weeks and remained at this lower level until the end of the study at 14 weeks postoperatively. Satiety ratio was higher during daytime than nighttime in both sham-operated and GB rats, but was not significantly different between the two groups. Neither daily accumulated food intake nor food intake per 100 g of body weight was different between sham-operated and GB rats. Apparently, GB rats ate more frequently during daytime and had smaller meal size during nighttime at 3 weeks postoperatively. These changes were not present at 14 weeks postoperatively. Energy density in the feces was the same in GB and sham-operated rats postoperatively. Energy expenditure declined with age, but increased in GB rats compared with age-matched sham-operated rats.

Conclusions

GB reduced the body weight without causing early satiety, reducing food intake or inducing malabsorption. It did, however, increase energy expenditure.
Literature
1.
Bray GA, Tartaglia LA. Medicinal strategies in the treatment of morbid obesity. Nature. 2000;404:672–7.PubMed
2.
Mun EC, Blackburn GL, Matthews JB. Current status of medical and surgical therapy for obesity. Gastroenterology. 2001;120:669–81.PubMedCrossRef
3.
Solomon C, Dluhy RG. Bariatric surgery—Quick fix or long-term solution? N Engl J Med. 2004;351:2751–3.PubMedCrossRef
4.
Wolfe BM, Austrheim-Smith IT, Ghaderi N. Surgical treatment of obesity: pyloric electrical stimulation. Gastroenterology. 2005;128:225–8.PubMedCrossRef
5.
O’Brien PE, McPhail T, Chaston TB, et al. Systematic review of medium-term weight loss after bariatric operations. Obes Surg. 2006;16:1032–40.PubMedCrossRef
6.
Elder KA, Wolfe BM. Bariatric surgery: a review of procedures and outcomes. Gastroenterology. 2007;132:2253–71.PubMedCrossRef
7.
Kirchner H, Guijarro A, Meguid MM. Is a model useful in exploring the catabolic mechanisms of weight loss after gastric bypass in humans? Curr Opin Clin Nutr Metab Care. 2007;10:463–74.PubMedCrossRef
8.
Stenström B, Furnes MW, Tømmerås K, et al. Mechanism of gastric bypass-induced body weight loss: one-year follow-up after micro-gastric bypass in rats. J Gastrointest Surg. 2006;10:1384–91.PubMedCrossRef
9.
Furnes MW, Stenström B, Tømmerås K, et al. Feeding behaviour in rats subjected to gastrectomy or gastric bypass surgery. Eur Surg Res. 2007 (in press).
10.
Egecioglu E, Stenström B, Pinnock SB, et al. Hypothalamic gene expression following ghrelin therapy to gastrectomized rodents. Regul Pept. 2007 [Epub ahead of print].
11.
Guijarro A, Suzuki S, Chen C, et al. Characterization of weight loss and weight regain mechanisms after Roux-en-Y gastric bypass in rats. Am J Physiol Regul Integr Comp Physiol. 2007;293:R1474–89.PubMed
12.
Varma M, Chai JK, Meguid MM, et al. Effect of estradiol and progesterone on daily rhythm in food intake and feeding patterns in Fischer rats. Physiol Behav. 1999;68:99–107.PubMedCrossRef
13.
Zorrilla EP, Inoue K, Fekete EM, et al. Measuring meals: structure of prandial food and water intake of rats. Am J Physiol Regul Integr Comp Physiol. 2005;288:R1450–67.PubMed
14.
Camilleri M, Grudell AB. Appetite and obesity: a gastroenterologist’s perspective. Neurogastroenterol Motil. 2007;19:333–41.PubMedCrossRef
15.
Brolin RL, Robertson LB, Kenler HA, et al. Weight loss and dietary intake after vertical banded gastroplasty and Roux-en-Y gastric bypass. Ann Surg. 1994;220:782–90.PubMedCrossRef
16.
Warde-Kamar J, Rogers M, Flancbaum L, et al. Calorie intake and meal patterns up to 4 years after Roux-en-Y gastric bypass surgery. Obes Surg. 2004;14:1070–9.PubMedCrossRef
17.
Zhao CM, Furnes MW, Stenström B, et al. Characterization of obestatin- and ghrelin-producing cells in the gastrointestinal tract and pancreas of rats: an immunohistochemical and electron microscopic study. Cell Tissue Res. 2007 (in press).
18.
Arch JR. beta (3)-Adrenoceptor agonists: potential, pitfalls and progress. Eur J Pharmacol. 2002;440:99–107.PubMedCrossRef
Metadata
Title
Gastric Bypass Surgery Causes Body Weight Loss Without Reducing Food Intake in Rats
Authors
Marianne W. Furnes
Karin Tømmerås
Carl-Jørgen Arum
Chun-Mei Zhao
Duan Chen
Publication date
01-04-2008
Publisher
Springer-Verlag
Published in
Obesity Surgery / Issue 4/2008
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-007-9392-8

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