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Open Access 01-03-2009 | Article

Teasing apart the heterogeneity of autism: Same behavior, different brains in toddlers with fragile X syndrome and autism

Authors: Heather Cody Hazlett, Michele D. Poe, Amy A. Lightbody, Guido Gerig, James R. MacFall, Allison K. Ross, James Provenzale, Arianna Martin, Allan L. Reiss, Joseph Piven

Published in: Journal of Neurodevelopmental Disorders | Issue 1/2009

Abstract

To examine brain volumes in substructures associated with the behavioral features of children with FXS compared to children with idiopathic autism and controls. A cross-sectional study of brain substructures was conducted at the first time-point as part of an ongoing longitudinal MRI study of brain development in FXS. The study included 52 boys between 18–42 months of age with FXS and 118 comparison children (boys with autism-non FXS, developmental-delay, and typical development). Children with FXS and autistic disorder had substantially enlarged caudate volume and smaller amygdala volume; whereas those children with autistic disorder without FXS (i.e., idiopathic autism) had only modest enlargement in their caudate nucleus volumes but more robust enlargement of their amygdala volumes. Although we observed this double dissociation among selected brain volumes, no significant differences in severity of autistic behavior between these groups were observed. This study offers a unique examination of early brain development in two disorders, FXS and idiopathic autism, with overlapping behavioral features, but two distinct patterns of brain morphology. We observed that despite almost a third of our FXS sample meeting criteria for autism, the profile of brain volume differences for children with FXS and autism differed from those with idiopathic autism. These findings underscore the importance of addressing heterogeneity in studies of autistic behavior.

American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. Washington, DC: American Psychiatric Association; 1994.

Geschwind DH. Autism: Family connections. Nature 2008;454:838–89.PubMedPubMedCentralCrossRef

Restifo LL. Mental retardation genes in drosophila: New approaches to understanding and treating developmental brain disorders. Ment Retard Dev Disabil Res Rev 2005;11:286–94.PubMedCrossRef

Bailey DB Jr, Mesibov GB, Hatton DD, Clark RD, Roberts JE, Mayhew L. Autistic behavior in young boys with fragile X syndrome. J Autism Dev Disord 1998;28:499–508.PubMedCrossRef

Rogers SJ, Wehner DE, Hagerman R. The behavioral phenotype in fragile X: symptoms of autism in very young children with fragile X syndrome, idiopathic autism, and other developmental disorders. J Dev Behav Pediatr 2001;22:409–17.PubMedCrossRef

Baumgardner TL, Reiss AL, Freund LS, Abrams MT. Specification of the neurobehavioral phenotype in males with fragile X syndrome. Pediatrics 1995;95:744–52.PubMed

Bailey DB Jr, Mesibov GB, Hatton DD, Clark RD, Roberts JE, Mayhew L. Autistic behavior in young boys with fragile X syndrome. J Autism Dev Disord 1998;28:499–508.PubMedCrossRef

Bailey DB Jr, Hatton DD, Mesibov G, Ament N, Skinner M. Early development, temperament, and functional impairment in autism and fragile X syndrome. J Autism Dev Disord 2000;30:49–59.PubMedCrossRef

Bregman JD, Leckman JF, Ort SI. Fragile X syndrome: genetic predisposition to psychopathology. J Autism Dev Disord 1988;18:343–54.PubMedCrossRef

10.

Lachiewicz AM, Spiridigliozzi GA, Gullion CM, Ransford SN, Rao K. Aberrant behaviors of young boys with fragile X syndrome. Am J Ment Retard 1994;98:567–79.PubMed

11.

Einfeld S, Tonge B, Turner G. Longitudinal course of behavioral and emotional problems in fragile X syndrome. Am J Med Genet 1999;87:436–9.PubMedCrossRef

12.

Hoeft F, Lightbody AA, Hazlett HC, Patnaik S, Piven J, Reiss A. Morphometric spatial patterns differentiating boys with fragile X syndrome, typically developing boys, and developmentally delayed boys aged 1 to 3 years. Arch Gen Psychiatry 2008;65(9):1087–97.PubMedPubMedCentralCrossRef

13.

Bailey A, LeCouteur A, Gottesman I, Bolton P, Simonoff E, Yudza E, et al. Autism as a strongly genetic disorder: Evidence from a British twin study. Psychol Med 1995;25:63–77.PubMedCrossRef

14.

Lainhart J, Piven J, Wzorek M, Santangelo S, Coon H, Folstein S. Macrocephaly in children and adults with autism. J Am Academy Child Adol Psychiatry 1997;36:282–9.CrossRef

15.

Stevenson R, Schroer R, Skinner C, Fender D, Simensen R. Autism and macrocephaly. Lancet 1997;349:1744–5.PubMedCrossRef

16.

Bailey A, Luthert P, Bolton P, LeCouteur A, Rutter M. Autism and megalencephaly. Lancet 1993;34:1225–6.CrossRef

17.

Bauman M, Kemper T. Histoanatomic observations of the brain in early infantile autism. Neurology 1985;35:866–74.PubMedCrossRef

18.

Piven J, Nehme E, Simon J, Barta P, Godfrey P, Folstein S. Magnetic resonance imaging in autism: Measurement of the cerebellum, pons, and fourth ventricle. Biol Psychiatry 1992;31:491–504.PubMedCrossRef

19.

Piven J, Ardnt S, Bailey J, Andreasen N. Regional brain enlargement in autism: A magnetic resonance imaging study. J Am Acad Child Adol Psychiatry 1996;35:530–6.CrossRef

20.

Courchesne E, Karns C, Davis H, Ziccardi R, Carper R, Tigue Z, et al. Unusual brain growth patterns in early life in patients with autistic disorder: An MRI study. Neurology 2001;57:245–54.PubMedCrossRef

21.

Sparks B, Friedman S, Shaw D, Aylward E, Echelard D, Artru A, et al. Brain structural abnormalities in young children with autism spectrum disorder. Neurology 2002;59(Suppl 2):184–92.PubMedCrossRef

22.

Hazlett HC, Poe M, Gerig G, Smith RG, Provenzale J, Ross A, et al. Magnetic resonance imaging and head circumference study of brain size in autism: birth through age 2 years. Arch Gen Psychiatry 2005;62:1366–76.PubMedCrossRef

23.

Aylward EH, Minshew NJ, Field K, Sparks BF, Singh N. Effects of age on brain volume and head circumference in autism. Neurology 2002;59(Suppl 2):175–83.PubMedCrossRef

24.

Herbert MR, Ziegler DA, Deutsch CK, O’Brien LM, Lange N, Bakardjiev A, et al. Dissociations of cerebral cortex, subcortical and cerebral white matter volumes in autistic boys. Brain 2003;126:1182–92.PubMedCrossRef

25.

Lotspeich LJ, Kwon H, Schumann CM, Fryer SL, Goodlin-Jones BL, Buonocore MH, et al. Investigation of neuroanatomical differences between autism and asperger syndrome. Arch Gen Psychiatry 2004;61:291–8.PubMedCrossRef

26.

Mosconi MW, Hazlett HC, Poe MD, Gerig G, Smith RG, Piven J. A longitudinal study of amygdala volume and joint attention in 2–4 year old children with autism. Arch Gen Psychiatry 2009 (in press).

27.

Hessl D, Rivera SM, Reiss AL. The neuroanatomy and neuroendocrinology of fragile X syndrome. Ment Retard Dev Disabil Res Rev 2004;10:17–24.PubMedCrossRef

28.

Reiss AL, Abrams MT, Greenlaw R, Freund L, Denckla MB. Neurodevelopmental effects of the FMR-1 full mutation in humans. Nat Med 1995;1:159–67.PubMedCrossRef

29.

Willemsen R, Mohkamsing S, de Vries B, Devys D, van den Ouweland A, Mandal JL, et al. Rapid antibody test for fragile X syndrome. Lancet 1995;345:1147–8.PubMedCrossRef

30.

Lord C, Rutter M, LeCouteur A. Autism Diagnostic Interview—Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. J Autism Dev Disord 1994;24(5):659–85.PubMedCrossRef

31.

DiLavore PC, Lord C, Rutter M. The pre-linguistic autism diagnostic observation schedule. J Autism Dev Disord 1995;25(4):355–79.PubMedCrossRef

32.

Mesibov GB, Schopler E, Schaffer B, Michal N. Use of the childhood autism rating scale with autistic adolescents and adults. J Am Acad Child Adol Psychiatry 1989;28(4):538–41.CrossRef

33.

Mullen EM. Mullen scales of early learning AGS edition. Circle Pines: American Guidance Service; 1995.

34.

Sparrow SS, Balla DA, Cicche HV. Vineland adaptive behavior scales—interview edition survey form manual. Circle Pines: American Guidance Service; 1984.

35.

Van Leemput K, Maes F, Vandermeulen D, Suetens P. Automated model-based bias field correction of MR images of the brain. IEEE Trans Med Imag 1999;18:885–96.CrossRef

36.

Van Leemput K, Maes F, Vandermeulen D, Suetens P. Automated model-based tissue classification of MR images of the brain. IEEE Trans Med Imag 1999;18:897–908.CrossRef

37.

Pastawa M, Gilmore J, Lin W, Gerig G. Automatic segmentation of neonatal brain MRI. Lect Notes Comput Sci (LNCS) 2004;3216:10–6.CrossRef

38.

Park J, Gerig G, Chakos M, Vandermeulen D, Lieberman JA. Neuroimaging of Psychiatry Disease: Reliable and efficient automatic brain tissue segmentation for increased sensitivity. Schizophr Res 2001;49(1–2):163.

39.

Styner M, Charles C, Park J, Gerig G. Multisite validation of image analysis methods—Assessing intra and inter site variability. Proc SPIE 2002;4684:278–86.CrossRef

40.

Ho S, Bullitt E, Gerig G. Level set evolution with region competition: automatic 3-D segmentation of brain tumors. In: Kasturi R, Laurendeau D, Suen C, editors. Proc. 16th Int Conf on Pattern Recognition ICPR. Los Alamitos: IEEE Computer Society; 2002. p. 532–5.

41.

Yuschevich PA, Piven J, Hazlett HC, Smith RG, Ho S, Gee JC, et al. User-guided ED active contour segmentation of anatomical structures: Significantly improved efficiency and reliability. NeuroImage 2006;31:1116–28.CrossRef

42.

Schumann CM, Hamstra J, Goodlin-Jones BL, Lotspeich LJ, Kwon H, Buonocore MH, et al. The amygdala is enlarged in children but not adolescents with autism; the hippocampus is enlarged at all ages. J Neurosci 2004;24:6392–401.PubMedCrossRef

43.

Csernansky JC, Joshi S, Wang L, Gado M, Philip J, Grenander ULF, et al. Hippocampal morphometry in schizophrenia by high dimensional brain mapping. Proc Natl Acad Sci 1998;95:11406–11.PubMedPubMedCentralCrossRef

44.

Joshi S, Grenander U, Miller MI. On the geometry and shape of brain sub-manifolds. Int J Pattern Recogn Artif Intell 1997;11(8):1317–43. (Special Issue on Processing of MR Images of the Human).CrossRef

45.

Miller MI, Joshi SC, Christensen GE. Large deformation fluid diffeomorphisms for landmark and image matching. In: Toga AW, editor. Brain warping. London: Academic Press; 1999.

46.

Joshi S, Davis B, Jomier M, Gerig G. Unbiased diffeomorphic atlas construction for computational anatomy. In: Thompson PM, Miller MI, Ratnanather T, Poldrack RA, Nichols TE, editors. NeuroImage; Supplement issue on mathematics in brain imaging. vol 23. Amsterdam: Elsevier; 2004. p. S151–S160.

47.

Gueorguieva R, Krystal JH. Move over ANOVA: Progress in analyzing repeated-measures data and its reflection in papers published in the Archives of General Psychiatry. Arch Gen Psychiatry 2004;61:310–7.PubMedCrossRef

48.

Gothelf D, Furfaro JA, Hoeft F, Eckert MA, Hall SS, O’Hara R, et al. Neuroanatomy of fragile X syndrome is associated with aberrant behavior and the fragile X mental retardation protein (FMRP). Ann Neurol 2008;63(1):40–51.PubMedPubMedCentralCrossRef

49.

Eliez S, Blasey CM, Freund LS, Hastie T, Reiss AL. Brain anatomy, gender and IQ in children and adolescents with fragile X syndrome. Brain 2001;124:1610–8.PubMedCrossRef

50.

Antar LN, Dictenberg JB, Plociniak M, Afroz R, Bassell GJ. Localization of FMRP-associated mRNA granules and requirement of microtubules for activity-dependent trafficking in hippocampal neurons. Genes Brain Behav 2005;4:350–9.PubMedCrossRef

51.

Rivera SM, Menon V, White CD, Glaser B, Reiss AL. Functional brain activation during arithmetic processing in females with fragile X Syndrome is related to FMR1 protein expression. Hum Brain Mapp 2002;16:206–18.PubMedCrossRef

52.

Hessl D, Tassone F, Loesch DZ, Berry-Kravis E, Leehey MA, Gane LW, et al. Abnormal elevation of FMR1 mRNA is associated with psychological symptoms in individuals with the fragile X premutation. Am J Med Genet B Neuropsychiatr Genet 2005;139:115–21.CrossRef

53.

Hatton DD, Sideris J, Skinner M, Mankowski J, Bailey DB Jr, Roberts J, et al. Autistic behavior in children with fragile X syndrome: prevalence, stability, and the impact of FMRP. Am J Med Genet A 2006;140:1804–13.CrossRef

54.

Loesch DZ, Huggins RM, Bui QM, Epstein JL, Taylor AK, Hagerman RJ. Effect of the deficits of fragile X mental retardation protein on cognitive status of fragile x males and females assessed by robust pedigree analysis. J Dev Behav Pediatr 2002;23:416–23.PubMedCrossRef

55.

Munson J, Dawson G, Abbott R, Faja S, Webb SJ, Friedman SD, et al. Amygdalar volume and behavioral development in autism. Arch Gen Psychiatry 2006;63:686–93.PubMedCrossRef

56.

Dalton KM, Nacewicz BM, Johnstone T, Schaefer HS, Gernsbacher MA, Goldsmith HH, et al. Gaze fixation and the neural circuitry of face processing in autism. Nat Neurosci 2005;8:519–26.PubMedPubMedCentral

57.

Nacewicz BM, Dalton KM, Johnstone T, Long MT, McAuliff EM, Oakes TR, et al. Amygdala volume and nonverbal social impairment in adolescent and adult males with autism. Arch Gen Psychiatry 2006;63:1417–28.PubMedCrossRef

58.

Zoghbi HY. Postnatal neurodevelopmental disorders: meeting at the synapse? Science 2003;302:826–30.PubMedCrossRef

Title: Teasing apart the heterogeneity of autism: Same behavior, different brains in toddlers with fragile X syndrome and autism
Authors: Heather Cody Hazlett
Michele D. Poe
Amy A. Lightbody
Guido Gerig
James R. MacFall
Allison K. Ross
James Provenzale
Arianna Martin
Allan L. Reiss
Joseph Piven
Publication date: 01-03-2009
Publisher: BioMed Central
Published in: Journal of Neurodevelopmental Disorders / Issue 1/2009
Print ISSN: 1866-1947
Electronic ISSN: 1866-1955
DOI: https://doi.org/10.1007/s11689-009-9009-8

At a glance: The STEP trials

Springer Medicine

Teasing apart the heterogeneity of autism: Same behavior, different brains in toddlers with fragile X syndrome and autism

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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