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Archives of Osteoporosis
Published in: Archives of Osteoporosis 1/2023

01-12-2023 | Sarcopenia | Original Article

Not only muscle mass but also muscle quality is associated with knee extension muscle strength in patients with hip fractures

Authors: Takuya Umehara, Akinori Kaneguchi, Keita Watanabe, Nobuhisa Katayama, Hidefumi Teramoto, Daisuke Kuwahara, Ryo Kaneyashiki, Toshiyuki Mizuno, Nobuhiro Kito, Masayuki Kakehashi

Published in: Archives of Osteoporosis | Issue 1/2023

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Abstract

Summary

Our results revealed that the decrease in isometric knee extension muscle strength on the operated and nonoperated sides in patients with hip fractures was associated with not only a decrease in skeletal muscle mass but also a decrease in muscle quality, characterized by a decreased PhA.

Purpose

This study aimed to assess the relationship between isometric knee extension muscle strength on the operated or nonoperated sides and PhA in patients with hip fractures at approximately 6 months postoperatively.

Methods

This study was a cross-sectional study. Skeletal muscle index (SMI), PhA, knee extension muscle strength on the operated and nonoperated sides, and other physical function variables were assessed at approximately 6 months postoperatively. To identify predictors of knee extension muscle strength on the operated and nonoperated sides, hierarchical multiple regression analysis was performed.

Results

A total of 90 patients with hip fractures were included (mean age, 80.1 ± 6.9 years). SMI (0.45) and PhA on the operated side (0.27) were the significant associated factors extracted for isometric knee extension muscle strength on the operated side (standardized partial regression coefficients), independent of age, sex, and body mass index (BMI). Movement control during one-leg standing on the nonoperated side (0.26), SMI (0.32), and PhA on the nonoperated side (0.40) were the significant associated factors extracted for isometric knee extension muscle strength on the nonoperated side, independent of age, sex and BMI.

Conclusions

Our results revealed that the decrease in isometric knee extension muscle strength on the operated and nonoperated sides in patients with hip fractures at approximately 6 months postoperatively was associated with not only a decrease in skeletal muscle mass but also a decrease in muscle quality, characterized by a decreased PhA.
Literature
1.
Dyer SM, Crotty M, Fairhall N, Magaziner J, Beaupre LA, Cameron ID, Sherrington C, Fragility Fracture Network Rehabilitation Research Special Interest G (2016) A critical review of the long-term disability outcomes following hip fracture. BMC Geriatr 16:158CrossRefPubMedPubMedCentral
2.
Madsen OR, Lauridsen UB, Sorensen OH (2000) Quadriceps strength in women with a previous hip fracture: relationships to physical ability and bone mass. Scand J Rehabil Med 32:37–40CrossRefPubMed
3.
Kristensen MT, Hulsbæk S, Faber LL, Kronborg L (2021) Knee extension strength measures indicating probable sarcopenia is associated with health-related outcomes and a strong predictor of 1-year mortality in patients following hip fracture surgery. Geriatrics (Basel) 6:8
4.
Nakamura T, Kamiya K, Hamazaki N et al (2021) Quadriceps strength and mortality in older patients with heart failure. Can J Cardiol 37:476–483CrossRefPubMed
5.
6.
Pua YH, Clark RA, Bryant AL (2010) Physical function in hip osteoarthritis: relationship to isometric knee extensor steadiness. Arch Phys Med Rehabil 91:1110–1116CrossRefPubMed
7.
Pua YH, Wrigley TV, Collins M, Cowan SM, Bennell KL (2009) Self-report and physical performance measures of physical function in hip osteoarthritis: relationship to isometric quadriceps torque development. Arthritis Rheum 61:201–208CrossRefPubMed
8.
Chen L, Nelson DR, Zhao Y, Cui Z, Johnston JA (2013) Relationship between muscle mass and muscle strength, and the impact of comorbidities: a population-based, cross-sectional study of older adults in the United States. BMC Geriatr 13:74CrossRefPubMedPubMedCentral
9.
Wada O, Kurita N, Kamitani T, Nakano N, Mizuno K (2019) Influence of the severity of knee osteoarthritis on the association between leg muscle mass and quadriceps strength: the SPSS-OK study. Clin Rheumatol 38:719–725CrossRefPubMed
10.
Kristensen MT, Bandholm T, Bencke J, Ekdahl C, Kehlet H (2009) Knee-extension strength, postural control and function are related to fracture type and thigh edema in patients with hip fracture. Clin Biomech (Bristol, Avon) 24:218–224CrossRefPubMed
11.
Portegijs E, Rantanen T, Kallinen M, Heinonen A, Alen M, Kiviranta I, Sipilä S (2009) Lower-limb pain, disease, and injury burden as determinants of muscle strength deficit after hip fracture. J Bone Joint Surg Am 91:1720–1728CrossRefPubMed
12.
Mateos-Angulo A, Galán-Mercant A, Cuesta-Vargas AI (2021) Muscle thickness and echo intensity by ultrasonography and cognitive and physical dimensions in older adults. Diagnostics (Basel) 11:1471
13.
Umehara T, Kaneguchi A, Yamasaki T, Katayama N, Kawakami W, Kuwahara D, Kito N (2023) Reduced upper and lower limb muscle strengths without reduced skeletal muscle in elderly patients with heart failure. J Rural Med 18: 8–14
14.
Goodpaster BH, Park SW, Harris TB, Kritchevsky SB, Nevitt M, Schwartz AV, Simonsick EM, Tylavsky FA, Visser M, Newman AB (2006) The loss of skeletal muscle strength, mass, and quality in older adults: the health, aging and body composition study. J Gerontol A Biol Sci Med Sci 61:1059–1064CrossRefPubMed
15.
Akamatsu Y, Kusakabe T, Arai H et al (2022) Phase angle from bioelectrical impedance analysis is a useful indicator of muscle quality. J Cachexia Sarcopenia Muscle 13:180–189CrossRefPubMed
16.
Kumar S, Dutt A, Hemraj S, Bhat S, Manipadybhima B (2012) Phase angle measurement in healthy human subjects through bio-impedance analysis. Iran J Basic Med Sci 15:1180–1184PubMedPubMedCentral
17.
Lukaski HC, Kyle UG, Kondrup J (2017) Assessment of adult malnutrition and prognosis with bioelectrical impedance analysis: phase angle and impedance ratio. Curr Opin Clin Nutr Metab Care 20:330–339CrossRefPubMed
18.
Norman K, Stobaus N, Pirlich M, Bosy-Westphal A (2012) Bioelectrical phase angle and impedance vector analysis–clinical relevance and applicability of impedance parameters. Clin Nutr 31:854–861CrossRefPubMed
19.
Yamada Y, Buehring B, Krueger D, Anderson RM, Schoeller DA, Binkley N (2017) Electrical properties assessed by bioelectrical impedance spectroscopy as biomarkers of age-related loss of skeletal muscle quantity and quality. J Gerontol A Biol Sci Med Sci 72:1180–1186PubMed
20.
Hirose S, Nakajima T, Nozawa N et al (2020) Phase angle as an indicator of sarcopenia, malnutrition, and cachexia in inpatients with cardiovascular diseases. J Clin Med 9
21.
Wada O, Kurita N, Yamada M, Mizuno K (2020) Structural severity, phase angle, and quadriceps strength among patients with knee osteoarthritis: the SPSS-OK study. Clin Rheumatol 39:3049–3056CrossRefPubMed
22.
Wada O, Yamada M, Kamitani T, Mizuno K, Kurita N (2021) The associations of phase angle with the structural severity and quadriceps strength among patients with hip osteoarthritis: the SPSS-OK study. Clin Rheumatol 40:1539–1546CrossRefPubMed
23.
Katoh M, Isozaki K (2014) Reliability of isometric knee extension muscle strength measurements of healthy elderly subjects made with a hand-held dynamometer and a belt. J Phys Ther Sci 26:1855–1859CrossRefPubMedPubMedCentral
24.
Lenzlinger-Asprion R, Keller N, Meichtry A, Luomajoki H (2017) Intertester and intratester reliability of movement control tests on the hip for patients with hip osteoarthritis. BMC Musculoskelet Disord 18:55CrossRefPubMedPubMedCentral
25.
Michikawa T, Nishiwaki Y, Takebayashi T, Toyama Y (2009) One-leg standing test for elderly populations. J Orthop Sci 14:675–685CrossRefPubMed
26.
Huang C, Niu K, Kobayashi Y et al (2013) An inverted J-shaped association of serum uric acid with muscle strength among Japanese adult men: a cross-sectional study. BMC Musculoskelet Disord 14:258CrossRefPubMedPubMedCentral
27.
Chen LK, Woo J, Assantachai P et al (2020) Asian Working Group for Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment. J Am Med Dir Assoc 21(300–307):e302
28.
Umehara T, Kaneguchi A, Kawakami W, Katayama N, Kito N (2022) Association of muscle mass and quality with hand grip strength in elderly patients with heart failure. Heart Vessels 37:1380–1386
29.
Labanca L, Ghislieri M, Knaflitz M, Barone G, Bragonzoni L, Agostini V, Benedetti MG (2021) Muscle synergies for the control of single-limb stance with and without visual information in young individuals. BMC Sports Sci Med Rehabil 13:163CrossRefPubMedPubMedCentral
30.
Yamada M, Kimura Y, Ishiyama D et al (2019) Phase angle is a useful indicator for muscle function in older adults. J Nutr Health Aging 23:251–255CrossRefPubMed
31.
Dos Santos L, Cyrino ES, Antunes M, Santos DA, Sardinha LB (2016) Changes in phase angle and body composition induced by resistance training in older women. Eur J Clin Nutr 70:1408–1413CrossRefPubMed
32.
Campa F, Silva AM, Toselli S (2018) Changes in Phase Angle and Handgrip Strength Induced by Suspension Training in Older Women. Int J Sports Med 39:442–449CrossRefPubMed
33.
Thibault R, Makhlouf AM, Mulliez A et al (2016) Fat-free mass at admission predicts 28-day mortality in intensive care unit patients: the international prospective observational study Phase Angle Project. Intensive Care Med 42:1445–1453CrossRefPubMed
34.
Wirth R, Volkert D, Rösler A, Sieber CC, Bauer JM (2010) Bioelectric impedance phase angle is associated with hospital mortality of geriatric patients. Arch Gerontol Geriatr 51:290–294CrossRefPubMed
35.
Garlini LM, Alves FD, Ceretta LB, Perry IS, Souza GC, Clausell NO (2019) Phase angle and mortality: a systematic review. Eur J Clin Nutr 73:495–508CrossRefPubMed
36.
Guzon-Illescas O, Perez Fernandez E, CrespíVillarias N, Quirós Donate FJ, Peña M, Alonso-Blas C, García-Vadillo A, Mazzucchelli R (2019) Mortality after osteoporotic hip fracture: incidence, trends, and associated factors. J Orthop Surg Res 14:203CrossRefPubMedPubMedCentral
Metadata
Title
Not only muscle mass but also muscle quality is associated with knee extension muscle strength in patients with hip fractures
Authors
Takuya Umehara
Akinori Kaneguchi
Keita Watanabe
Nobuhisa Katayama
Hidefumi Teramoto
Daisuke Kuwahara
Ryo Kaneyashiki
Toshiyuki Mizuno
Nobuhiro Kito
Masayuki Kakehashi
Publication date
01-12-2023
Publisher
Springer London
Keyword
Sarcopenia
Published in
Archives of Osteoporosis / Issue 1/2023
Print ISSN: 1862-3522
Electronic ISSN: 1862-3514
DOI
https://doi.org/10.1007/s11657-023-01251-9

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