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Archives of Osteoporosis
Published in: Archives of Osteoporosis 1/2023

01-12-2023 | Obesity | Original Article

The relationship between obesity and bone mineral density in children and adolescents: analysis of the National Health and Nutrition Examination Survey

Authors: Chun-Ming Ma, Na Lu, Meng-Meng Zhang, Fan-Shuo Kong, Qiang Lu, Fu-Zai Yin, Xu Zhang, Rui Wang

Published in: Archives of Osteoporosis | Issue 1/2023

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Abstract

Summary

Childhood and puberty are important period for the skeleton grows. Fat mass, especially visceral adipose tissue, was negatively correlated with areal bone mineral density in children and adolescents. The present study suggests that fat mass, especially visceral adipose tissue, has a slightly negative association with bone development in children and adolescents.

Purpose

This study observed the relationship between fat mass and distribution, and areal bone mineral density (aBMD) in children and adolescents.

Methods

A retrospective study was conducted on US children and adolescents aged 8–19 years. Whole body (less head) aBMD was evaluated. Height (Ht) adjusted Z-scores for aBMD were calculated.

Results

After controlling for age, gender, race, and lean body mass index (LBMI) Z-score, there were significant negative associations between fat mass index (FMI) Z-score and aBMD Ht-Z-adjusted Z-score (β =  − 0.272, P < 0.001, R2 = 0.033). In the linear regression models with aBMD Ht-Z-adjusted Z-score as the dependent variable, the regression coefficients of android fat mass were − 0.241 (P < 0.05, R2 = 0.002), − 0.473 (P < 0.001, R2 = 0.036), and − 0.474 (P < 0.001, R2 = 0.038) for healthy weight, overweight, and obesity group, respectively. The regression coefficients of visceral adipose tissue (VAT) mass were − 0.218 (P > 0.05, R2 = 0.001), − 2.025 (P < 0.001, R2 = 0.044), and − 1.826 (P < 0.001, R2 = 0.039), and the regression coefficients of subcutaneous adipose tissue (SAT) mass were − 0.467 (P < 0.001, R2 = 0.004), − 0.339 (P < 0.01, R2 = 0.024), and − 0.347 (P < 0.001, R2 = 0.018) for healthy weight, overweight, and obesity group, respectively.

Conclusions

The present study suggests that fat mass has a slightly negative association with bone development in children and adolescents. Trunk fat accumulation, especially visceral adipose tissue, was correlated with the lower level of aBMD. This association was obvious in overweight and obese children.
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Metadata
Title
The relationship between obesity and bone mineral density in children and adolescents: analysis of the National Health and Nutrition Examination Survey
Authors
Chun-Ming Ma
Na Lu
Meng-Meng Zhang
Fan-Shuo Kong
Qiang Lu
Fu-Zai Yin
Xu Zhang
Rui Wang
Publication date
01-12-2023
Publisher
Springer London
Published in
Archives of Osteoporosis / Issue 1/2023
Print ISSN: 1862-3522
Electronic ISSN: 1862-3514
DOI
https://doi.org/10.1007/s11657-022-01208-4

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