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Archives of Osteoporosis
Published in: Archives of Osteoporosis 1/2021

01-12-2021 | Osteoporosis | Original Article

Predictive factors of non-treatment and non-persistence to osteoporosis medication after fragility hip fractures at 3 years after discharge: a multicentre, prospective cohort study in the northern Kyushu district of Japan

Authors: Masaya Kanahori, Yoshihiro Matsumoto, Toshifumi Fujiwara, Atsushi Kimura, Tomoko Tsutsui, Shinkichi Arisumi, Akiko Oyamada, Masanobu Ohishi, Ko Ikuta, Kuniyoshi Tsuchiya, Naohisa Tayama, Shinji Tomari, Hisaaki Miyahara, Takao Mae, Toshihiko Hara, Taichi Saito, Takeshi Arizono, Kozo Kaji, Taro Mawatari, Masami Fujiwara, Minoru Takasaki, Kunichika Shin, Kenichi Ninomiya, Kazutoshi Nakaie, Yasuaki Antoku, Yukihide Iwamoto, Yasuharu Nakashima

Published in: Archives of Osteoporosis | Issue 1/2021

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Abstract

Summary

We examined osteoporosis medication use and factors affecting persistence in 497 patients with fragility hip fractures. Only 25.5% of patients received continuous medication for 3 years, and 44.1% of patients received no treatment. Low Barthel index at discharge was a risk factor for both non-treatment and non-persistence to osteoporosis medication.

Purpose

Fragility hip fractures (FHF) caused by osteoporosis decrease the quality of life and worsen life expectancy. Use of osteoporosis medication may be an efficient method in the prevention of secondary FHF. However, previous studies have reported low rates of osteoporosis medication and persistence after FHF. This study aimed to evaluate osteoporosis medication use and factors affecting persistence in patients with FHF in the northern Kyushu area of Japan.

Methods

A total of 497 FHF patients aged ≥ 60 years with a 3-year follow-up were included. We prospectively collected data from questionnaires sent every 6 months regarding compliance with osteoporosis medication. We compared baseline characteristics among three groups: no treatment (NT), no persistence (NP), and persistence (P), and conducted multivariable regression models to determine covariates associated with non-treatment (NT vs. NP/P) and non-persistence (NP vs. P).

Results

There were 219 (44.1%), 151 (30.4%), and 127 (25.5%) patients in the NT, NP, and P groups, respectively. Factors associated with non-treatment were male sex, chronic kidney disease, no previous osteoporosis treatment, and low Barthel index (BI) at discharge. The only factor associated with non-persistence was a low BI at discharge. Factors associated with a low BI at discharge were male sex, older age, trochanteric fracture, and surgical delay.

Conclusion

Low BI at discharge is a risk factor for both non-treatment and non-persistence to osteoporosis medication. Therefore, appropriate interventions to improve BI may result in persistence to osteoporosis medication.
Appendix
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Metadata
Title
Predictive factors of non-treatment and non-persistence to osteoporosis medication after fragility hip fractures at 3 years after discharge: a multicentre, prospective cohort study in the northern Kyushu district of Japan
Authors
Masaya Kanahori
Yoshihiro Matsumoto
Toshifumi Fujiwara
Atsushi Kimura
Tomoko Tsutsui
Shinkichi Arisumi
Akiko Oyamada
Masanobu Ohishi
Ko Ikuta
Kuniyoshi Tsuchiya
Naohisa Tayama
Shinji Tomari
Hisaaki Miyahara
Takao Mae
Toshihiko Hara
Taichi Saito
Takeshi Arizono
Kozo Kaji
Taro Mawatari
Masami Fujiwara
Minoru Takasaki
Kunichika Shin
Kenichi Ninomiya
Kazutoshi Nakaie
Yasuaki Antoku
Yukihide Iwamoto
Yasuharu Nakashima
Publication date
01-12-2021
Publisher
Springer London
Published in
Archives of Osteoporosis / Issue 1/2021
Print ISSN: 1862-3522
Electronic ISSN: 1862-3514
DOI
https://doi.org/10.1007/s11657-021-00988-5

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