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Archives of Osteoporosis
Published in: Archives of Osteoporosis 1/2021

01-12-2021 | Original Article

3D analysis of bone mineral density in a cohort: age- and sex-related differences

Authors: Carmen Valero, José Manuel Olmos, Ludovic Humbert, Jesús Castillo, José Luis Hernández, Josefina Martínez, Jesús González Macías

Published in: Archives of Osteoporosis | Issue 1/2021

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Abstract

Summary

Women have lower areal BMD (g/cm2) than men; however, the women have smaller-size bones. Our study showed that women ≤ 59 years have a hip volumetric BMD by DXA 3D similar to that of men of the same age. This makes us think about the importance of taking into account bone size at the time of analyzing the sex-related differences in bone mass.

Purpose

Women have lower areal BMD (g/cm2) than men; however, these studies do not take into account that women have smaller-size bones. Recently, three-dimensional (3D) modeling methods were proposed to analyze volumetric BMD (vBMD). We want to determine the values of vBMD at the hip by DXA-based 3D modeling in a cohort of people in order to know the age- and sex-related differences.

Methods

A total of 2647 people of both sexes (65% women) were recruited from a large cohort (Camargo cohort, Santander, Spain). 3D-SHAPER® software (version 2.8, Galgo Medical, Barcelona, Spain) was used to derive 3D analysis from the hip DXA scans at baseline

Results

The differences were less pronounced for vBMD (cortical sBMD 9.3%, trabecular vBMD 6.4%, integral vBMD 2.2%) compared to aBMD (FN aBMD 11.4% and TH aBMD 13.3%). After stratifying by age (≤ 59 years, 60–69 years, 70–79 years, and ≥ 80 years), we observed in ≤ 59 years that aBMD was lower in women compared to men, at FN (0.758 [0.114] g/cm2 vs. 0.833 [0.117] g/cm2; p = 1.4 × 10−20) and TH (0.878 [0.117] g/cm2 vs. 0.990 [0.119] g/cm2; p = 4.1 × 10−40). Nevertheless, no statistically significant difference was observed for integral vBMD (331 [58] mg/cm3 in women and 326 [51] mg/cm3 in men; p = 0.19) and trabecular vBMD (190 [41] mg/cm3 in women and 195 [39] mg/cm3 in men; p = 0.20).

Conclusion

Our results make us think about the importance of taking into account bone size at the time of analyzing the sex-related differences in bone mass.
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Metadata
Title
3D analysis of bone mineral density in a cohort: age- and sex-related differences
Authors
Carmen Valero
José Manuel Olmos
Ludovic Humbert
Jesús Castillo
José Luis Hernández
Josefina Martínez
Jesús González Macías
Publication date
01-12-2021
Publisher
Springer London
Published in
Archives of Osteoporosis / Issue 1/2021
Print ISSN: 1862-3522
Electronic ISSN: 1862-3514
DOI
https://doi.org/10.1007/s11657-021-00921-w

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