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Open Access 01-12-2021 | Sarcopenia | Original Article

The serum 25(OH)D level and hand grip strength for fall risk assessment among osteoporotic elderly Japanese women

Authors: Takashi Nagai, Ichiro Okano, Koji Ishikawa, Takuma Kuroda, Yusuke Oshita, Koki Tsuchiya, Soji Tani, Hiroki Okamura, Keizo Sakamoto, Katsunori Inagaki

Published in: Archives of Osteoporosis | Issue 1/2021

Abstract

Summary

We investigated the relationship between serum 25(OH)D levels, grip strength, and fall score in elderly osteoporotic women for fall risk assessment. Both low serum 25(OH)D and low grip strength were independently associated with increased fall risk. The serum 25(OH)D cutoff specific to increased fall risk was 14 mg/dL (35 nmol/L).

Purpose

This study aimed to establish a cutoff value of serum 25-hydroxyvitamin D (25(OH)D) for fall assessment and investigate the relationship between serum 25(OH)D, grip strength, and fall score adjusted for age in osteoporotic elderly Japanese women.

Methods

This is a cross-sectional study utilizing collected data of osteoporotic elderly (age ≥65 years) female patients. A questionnaire for fall risk assessment was used, in which a score ≥ 6 was determined as increased fall risk. Serum 25(OH)D levels and grip strength were measured, and the cutoff points were calculated by receiver operating curve (ROC) analysis. Logistic regression analysis with age adjustment was conducted for potential risk factors for fall.

Results

After applying eligibility criteria, finally, 349 patients were enrolled. The median patient age was 77.0 years, and the mean serum 25(OH)D level was 15.6 ng/mL (36 nmol/L). Based on the ROC analysis, we defined the cutoff values of serum 25(OH)D level and grip strength as 14 ng/mL (35 nmol/L) and 15 kg, respectively. A multivariate analysis adjusted for age was conducted. Low serum 25(OH)D level and grip strength were independent risk factors for ≥6 fall risk scores.

Conclusion

Both low serum 25(OH)D level and low grip strength were independently associated with increased fall risk score in osteoporotic elderly women. The appropriate serum 25(OH)D cutoff specific to the increased fall risk group in this population was 14 mg/dL (35 nmol/L). These findings might be used for the identification of patients with high fall risks. These results should be confirmed in other patient groups.

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Title: The serum 25(OH)D level and hand grip strength for fall risk assessment among osteoporotic elderly Japanese women
Authors: Takashi Nagai
Ichiro Okano
Koji Ishikawa
Takuma Kuroda
Yusuke Oshita
Koki Tsuchiya
Soji Tani
Hiroki Okamura
Keizo Sakamoto
Katsunori Inagaki
Publication date: 01-12-2021
Publisher: Springer London
Keywords: Sarcopenia
Osteoporosis
Osteoporosis
Published in: Archives of Osteoporosis / Issue 1/2021
Print ISSN: 1862-3522
Electronic ISSN: 1862-3514
DOI: https://doi.org/10.1007/s11657-021-00901-0

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

The serum 25(OH)D level and hand grip strength for fall risk assessment among osteoporotic elderly Japanese women

Abstract

Summary

Purpose

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Summary

Purpose

Methods

Results

Conclusion

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