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Published in: Archives of Osteoporosis 1/2020

01-12-2020 | Vitamin D Deficiency | Consensus Statement

Diagnosis and management of vitamin D deficiency in the Gulf Cooperative Council (GCC) countries: an expert consensus summary statement from the GCC vitamin D advisory board

Authors: Yousef Al Saleh, Salem A. Beshyah, Wiam Hussein, Abdulrazzaq Almadani, Ahmed Hassoun, Ali Al Mamari, Ebtesam Ba-Essa, Essa Al-Dhafiri, Mohammed Hassanein, Mona A. Fouda, Nadia Al Ali, Naji Aljohani, Nasreen Al-Sayed, Neil Gittoes, Tarik Elhadd, Waleed Al-Baker, Shaun Sabico, Nasser Al-Daghri

Published in: Archives of Osteoporosis | Issue 1/2020

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Abstract

Objective

A summary of recommendations is given within the Gulf Cooperation Council (GCC) setting on the assessment and management of vitamin D deficiency in the region.

Methods

An assembly of 11 regional experts gathered to formulate an all-inclusive approach to vitamin D deficiency within GCC.

Results and Conclusion

Several gaps were identified before regional guidelines could be developed. These include adequacy and standardization of vitamin D testing, frequency of repeated testing and reference ranges, distinguishing prevention from the treatment of vitamin D deficiency, quality assurance of vitamin D products sold within GCC including contents and origins of products, and cut-points for vitamin D levels in local populations. A platform is created that can be further developed for overall regional implementation.
Literature
1.
go back to reference Knight JA, Wong J, Cole DEC, Lee TK, Parra EJ (2017) Predictors of 25-hydroxyvitamin D concentration measured at multiple time points in a multi-ethnic population. Am J Epidemiol 186(10):1180–1193PubMedPubMedCentral Knight JA, Wong J, Cole DEC, Lee TK, Parra EJ (2017) Predictors of 25-hydroxyvitamin D concentration measured at multiple time points in a multi-ethnic population. Am J Epidemiol 186(10):1180–1193PubMedPubMedCentral
2.
go back to reference Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM, Endocrine Society (2011) Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 96(7):1911–1930PubMed Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM, Endocrine Society (2011) Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 96(7):1911–1930PubMed
3.
go back to reference IOM (Institute of Medicine). Dietary reference intakes for calcium and vitamin D Committee to Review Dietary Reference Intakes for Calcium and Vitamin D. Washington, DC: National Academies Press, Institute of Medicine, 2011 IOM (Institute of Medicine). Dietary reference intakes for calcium and vitamin D Committee to Review Dietary Reference Intakes for Calcium and Vitamin D. Washington, DC: National Academies Press, Institute of Medicine, 2011
4.
go back to reference Al-Daghri NM, Al-Saleh Y, Aljohani N, Sulimani R, Al-Othman AM, Alfawaz H, Fouda M, Al-Amri F, Shahrani A, Alharbi M, ALshahrani F, Tamimi W, Sabico S, Rizzoli R, Reginster JY (2017) Vitamin D status correction in Saudi Arabia: an experts’ consensus under the auspices of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis, and Muskuloskeletal Diseases (ESCEO). Arch Osteoporos 12(1):1PubMed Al-Daghri NM, Al-Saleh Y, Aljohani N, Sulimani R, Al-Othman AM, Alfawaz H, Fouda M, Al-Amri F, Shahrani A, Alharbi M, ALshahrani F, Tamimi W, Sabico S, Rizzoli R, Reginster JY (2017) Vitamin D status correction in Saudi Arabia: an experts’ consensus under the auspices of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis, and Muskuloskeletal Diseases (ESCEO). Arch Osteoporos 12(1):1PubMed
5.
go back to reference Haq A, Wimalawansa SJ, Pludowski P, Anouti FA (2018) Clinical practice guidelines for vitamin D in the United Arab Emirates. J Steroid Biochem Mol Biol 175:4–11PubMed Haq A, Wimalawansa SJ, Pludowski P, Anouti FA (2018) Clinical practice guidelines for vitamin D in the United Arab Emirates. J Steroid Biochem Mol Biol 175:4–11PubMed
6.
go back to reference Green RJ, Samy G, Miqdady MS, El-Hodhod M, Akinyinka OO, Saleh G, Haddad J, Alsaedi SA, Mersal AY, Edris A, Salah M (2015) Vitamin D deficiency and insufficiency in Africa and the Middle East, despite year-round sunny days. S Afr Med J 105(7):603–605PubMed Green RJ, Samy G, Miqdady MS, El-Hodhod M, Akinyinka OO, Saleh G, Haddad J, Alsaedi SA, Mersal AY, Edris A, Salah M (2015) Vitamin D deficiency and insufficiency in Africa and the Middle East, despite year-round sunny days. S Afr Med J 105(7):603–605PubMed
7.
go back to reference Bassil D, Rahme M, Hoteit M, Fuleihan G-H (2013) Hypovitaminosis D in the Middle East and North Africa: prevalence, risk factors and impact on outcomes. Dermatoendocrinol 592:274–298 Bassil D, Rahme M, Hoteit M, Fuleihan G-H (2013) Hypovitaminosis D in the Middle East and North Africa: prevalence, risk factors and impact on outcomes. Dermatoendocrinol 592:274–298
8.
go back to reference Kelishadi R, Ardalan G, Motlagh ME, Shariatinejad K, Heshmat R, Poursafa P, Fakhri M, Tajadini M, Taslimi M (2014) National report on the association of serum vitamin D with cardiometabolic risk factors in the pediatric population of the Middle East and North Africa (MENA): the CASPIAN-III Study. Nutrition 30(1):33–38PubMed Kelishadi R, Ardalan G, Motlagh ME, Shariatinejad K, Heshmat R, Poursafa P, Fakhri M, Tajadini M, Taslimi M (2014) National report on the association of serum vitamin D with cardiometabolic risk factors in the pediatric population of the Middle East and North Africa (MENA): the CASPIAN-III Study. Nutrition 30(1):33–38PubMed
9.
go back to reference Chakhtoura M, Rahme M, Chamoun N, El-Hajj FG (2018) Vitamin D in the Middle East and North Africa. Bone 8:135–146 Chakhtoura M, Rahme M, Chamoun N, El-Hajj FG (2018) Vitamin D in the Middle East and North Africa. Bone 8:135–146
10.
go back to reference Al-Daghri NM (2018) Vitamin D in Saudi Arabia: prevalence, distribution and disease associations. J Steroid Biochem Mol Biol 175:102–107PubMed Al-Daghri NM (2018) Vitamin D in Saudi Arabia: prevalence, distribution and disease associations. J Steroid Biochem Mol Biol 175:102–107PubMed
11.
go back to reference Haq A, Svobodova J, Imran S, Stanford C, Razzaque MS (2016) Vitamin D deficiency: a single center analysis of patients from 136 countries. J Steroid Biochem Mol Biol 164:209–213PubMed Haq A, Svobodova J, Imran S, Stanford C, Razzaque MS (2016) Vitamin D deficiency: a single center analysis of patients from 136 countries. J Steroid Biochem Mol Biol 164:209–213PubMed
12.
go back to reference Golbahar J, Al-Saffar N, Altayab DIab D, Al-Othman S, Darwish A, Al-Kafaji G (2014) Predictors of vitamin D deficiency and insufficiency in adult Bahrainis: a cross-sectional study. Public Health Nutr 17(4):732–738PubMed Golbahar J, Al-Saffar N, Altayab DIab D, Al-Othman S, Darwish A, Al-Kafaji G (2014) Predictors of vitamin D deficiency and insufficiency in adult Bahrainis: a cross-sectional study. Public Health Nutr 17(4):732–738PubMed
13.
go back to reference Al-Dabhani K, Tsilidis KK, Murphy N, Ward HA, Elliott P, Riboli E, Gunter M, Tzoulaki I (2014) Prevalence of vitamin D deficiency and association with metabolic syndrome in a Qatari population. Nutr Diabetes 7(4):e263 Al-Dabhani K, Tsilidis KK, Murphy N, Ward HA, Elliott P, Riboli E, Gunter M, Tzoulaki I (2014) Prevalence of vitamin D deficiency and association with metabolic syndrome in a Qatari population. Nutr Diabetes 7(4):e263
14.
go back to reference Al-Kindi MK (2011) Vitamin D status in healthy Omani women of childbearing age: study of female staff at the Royal Hospital, Muscat, Oman. Sultan Qaboos Univ Med J 11(1):56–61PubMedPubMedCentral Al-Kindi MK (2011) Vitamin D status in healthy Omani women of childbearing age: study of female staff at the Royal Hospital, Muscat, Oman. Sultan Qaboos Univ Med J 11(1):56–61PubMedPubMedCentral
15.
go back to reference Zhang FF, Al Hooti S, Al Zenki S, Alomirah H, Jamil KM, Rao A, Al Jahmah N, Saltzman E, Ausman LM (2016) Vitamin D deficiency is associated with high prevalence of diabetes in Kuwait adults: results from a national survey. BMC Public Health Nutr 16:100 Zhang FF, Al Hooti S, Al Zenki S, Alomirah H, Jamil KM, Rao A, Al Jahmah N, Saltzman E, Ausman LM (2016) Vitamin D deficiency is associated with high prevalence of diabetes in Kuwait adults: results from a national survey. BMC Public Health Nutr 16:100
16.
go back to reference Pludowski P, Holick MF, Grant WB, Konstantynowicz J, Macarenhas MR, Haq A, Povoroznyuk V, Balatska N, Barbosa AP, Karonova T, Rudenka E, Misiorowski W, Zakhrova I, Rudenka A, Lukaszkiewicz J, Marcinowska-Suchowierska E, Laszcz N, Abramowicz P, Bhattoa HP, Wimalawansa SJ (2018) Vitamin D supplementation guidelines. J Steroid Biochem Mol Biol 175:125–135PubMed Pludowski P, Holick MF, Grant WB, Konstantynowicz J, Macarenhas MR, Haq A, Povoroznyuk V, Balatska N, Barbosa AP, Karonova T, Rudenka E, Misiorowski W, Zakhrova I, Rudenka A, Lukaszkiewicz J, Marcinowska-Suchowierska E, Laszcz N, Abramowicz P, Bhattoa HP, Wimalawansa SJ (2018) Vitamin D supplementation guidelines. J Steroid Biochem Mol Biol 175:125–135PubMed
17.
go back to reference Management of endocrine disease: current vitamin D status in European and Middle East countries and strategies to prevent vitamin D deficiency; a position statement of the European Calcified Tissue Society. Eur J Endocrinol 2019 Management of endocrine disease: current vitamin D status in European and Middle East countries and strategies to prevent vitamin D deficiency; a position statement of the European Calcified Tissue Society. Eur J Endocrinol 2019
18.
go back to reference Pilz S, Zittermann A, Trummer C, Theiler-Schwetz V, Lerchbaum E, Keppel MH, Grubler MR, Marz W, Pandis M (2019) Vitamin D testing and treatment: a narrative review of current evidence. Endocr Connect 8(2):R27–R43PubMedPubMedCentral Pilz S, Zittermann A, Trummer C, Theiler-Schwetz V, Lerchbaum E, Keppel MH, Grubler MR, Marz W, Pandis M (2019) Vitamin D testing and treatment: a narrative review of current evidence. Endocr Connect 8(2):R27–R43PubMedPubMedCentral
19.
go back to reference AlQuaiz AM, Mujammami M, Hasanato RM, Alodhayani A, Shaik SA, Al-Daghri NM (2019) Vitamin D cutoff point in relation to parathyroid hormone: a population-based study in Riyadh City. Saudi Arabia Arch Osteoporos 14(1):22PubMed AlQuaiz AM, Mujammami M, Hasanato RM, Alodhayani A, Shaik SA, Al-Daghri NM (2019) Vitamin D cutoff point in relation to parathyroid hormone: a population-based study in Riyadh City. Saudi Arabia Arch Osteoporos 14(1):22PubMed
20.
go back to reference Munns CF, Shaw N, Kiely M, Specker BL, Thacher TD, Ozono K, Michigami T, Tiosano D, Mughal MZ, Makitie O, Ramos-Abad L, Ward L, DiMeglio LA, Atapattu N, Cassinelli H, Braegger C, Pettifor JM, Seth A, Idris HW, Bhatia V, Fu J, Goldberg G, Savendahl L, Khadgawat R, Pludowski P, Maddock J, Hypponen E, Oduwole A, Frew E, Aguiar M, Tulchinsky T, Butler G, Hogler W (2016) Global consensus recommendations on prevention and management of nutritional rickets. J Clin Endocrinol Metab 101(2):394–415PubMedPubMedCentral Munns CF, Shaw N, Kiely M, Specker BL, Thacher TD, Ozono K, Michigami T, Tiosano D, Mughal MZ, Makitie O, Ramos-Abad L, Ward L, DiMeglio LA, Atapattu N, Cassinelli H, Braegger C, Pettifor JM, Seth A, Idris HW, Bhatia V, Fu J, Goldberg G, Savendahl L, Khadgawat R, Pludowski P, Maddock J, Hypponen E, Oduwole A, Frew E, Aguiar M, Tulchinsky T, Butler G, Hogler W (2016) Global consensus recommendations on prevention and management of nutritional rickets. J Clin Endocrinol Metab 101(2):394–415PubMedPubMedCentral
21.
go back to reference Uday S, Hogler W (2017) Nutritional rickets and osteomalacia in the twenty-first century: revised concepts, public health, and prevention strategies. Curr Osteoporos Rep 15(4):293–302PubMedPubMedCentral Uday S, Hogler W (2017) Nutritional rickets and osteomalacia in the twenty-first century: revised concepts, public health, and prevention strategies. Curr Osteoporos Rep 15(4):293–302PubMedPubMedCentral
22.
go back to reference Trajanoska K, Morris JA, Oei L, Zheng HF, Evans DM, Kiel DP, Ohlsson C, Richards JB, Rivadeneira F, GEFOS/GENOMOS consortium and the 23andMe research team (2018) Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomization study. BMJ 362:k3225PubMedPubMedCentral Trajanoska K, Morris JA, Oei L, Zheng HF, Evans DM, Kiel DP, Ohlsson C, Richards JB, Rivadeneira F, GEFOS/GENOMOS consortium and the 23andMe research team (2018) Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomization study. BMJ 362:k3225PubMedPubMedCentral
23.
go back to reference Kahwati LC, Weber RP, Pan H, Gourlay M, LeBlanc E, Coker-Schwimmer M, Viswanathan M (2018) Vitamin D, calcium or combined supplementation for the primary prevention of fractures in community-dwelling adults: evidence report and systematic review for the US Preventive Services Task Force. JAMA 319(15):1600–1612PubMed Kahwati LC, Weber RP, Pan H, Gourlay M, LeBlanc E, Coker-Schwimmer M, Viswanathan M (2018) Vitamin D, calcium or combined supplementation for the primary prevention of fractures in community-dwelling adults: evidence report and systematic review for the US Preventive Services Task Force. JAMA 319(15):1600–1612PubMed
24.
go back to reference Kanis JA, Cooper C, Rizzoli R, Reginster JY, Scientific Advisory Board of the European Society for Clinical and Economic Aspects of Osteoporosis (ESCEO) and the Committees of Scientific Advisors and National Societies of the International Osteoporosis Foundation (IOF) (2019) European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int 30(1):3–44PubMed Kanis JA, Cooper C, Rizzoli R, Reginster JY, Scientific Advisory Board of the European Society for Clinical and Economic Aspects of Osteoporosis (ESCEO) and the Committees of Scientific Advisors and National Societies of the International Osteoporosis Foundation (IOF) (2019) European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int 30(1):3–44PubMed
25.
go back to reference Ihige T, Satoh M, Ogawa S, Nishimura M, Higashi T, Nomura F (2015) Assessment of vitamin D metabolism by LC-MS/MS. Rinsho Byori 63(4):457–464 Ihige T, Satoh M, Ogawa S, Nishimura M, Higashi T, Nomura F (2015) Assessment of vitamin D metabolism by LC-MS/MS. Rinsho Byori 63(4):457–464
26.
go back to reference Cashman KD, Kiely M, Kinsella M, Durazo-Arvizu RA, Tian L, Zhang Y, Lucey A, Flynn A, Gibney MJ, Vesper HW, Phinney KW, Coates PM, Picciano MF, Sempos CT (2013) Evaluation of vitamin D standardization program protocols for standardizing serum 25-hydroxyvitamin D data: a case study of the program’s potential for national nutrition and health surveys. Am J Clin Nutr 97(6):1235–1242PubMedPubMedCentral Cashman KD, Kiely M, Kinsella M, Durazo-Arvizu RA, Tian L, Zhang Y, Lucey A, Flynn A, Gibney MJ, Vesper HW, Phinney KW, Coates PM, Picciano MF, Sempos CT (2013) Evaluation of vitamin D standardization program protocols for standardizing serum 25-hydroxyvitamin D data: a case study of the program’s potential for national nutrition and health surveys. Am J Clin Nutr 97(6):1235–1242PubMedPubMedCentral
27.
go back to reference Sadat-Ali M, Al-Elq AH, Al-Shaikh IH, Al-Turki HA, Al-Ali AK, Al-Othman AA (2014) Assessment of low vitamin D among Saudi Arabians. Did we overshoot the runway? Saudi Med J 35(10):1243–1249PubMedPubMedCentral Sadat-Ali M, Al-Elq AH, Al-Shaikh IH, Al-Turki HA, Al-Ali AK, Al-Othman AA (2014) Assessment of low vitamin D among Saudi Arabians. Did we overshoot the runway? Saudi Med J 35(10):1243–1249PubMedPubMedCentral
28.
go back to reference Dafterdar R, Al-Fayoumi M, Saadeddin S, Khan R, Alothaim A, Hasanato R, Al-Shangiti A, Fakhoury H, Tamimi W (2014) Vitamin D immunoassay systems: a comparison. Br J Biomed Sci 71(3):127–130PubMed Dafterdar R, Al-Fayoumi M, Saadeddin S, Khan R, Alothaim A, Hasanato R, Al-Shangiti A, Fakhoury H, Tamimi W (2014) Vitamin D immunoassay systems: a comparison. Br J Biomed Sci 71(3):127–130PubMed
29.
go back to reference Razzaque MS (2018) Sunlight exposure: do health benefits outweigh harm? J Steroid Biochem Mol Biol 175:44–48PubMed Razzaque MS (2018) Sunlight exposure: do health benefits outweigh harm? J Steroid Biochem Mol Biol 175:44–48PubMed
30.
go back to reference Alshahrani FM, Almalki MH, Aljohani N, Alzahrani A, Alsaleh Y, Holick MF (2013) Vitamin D light siside and best time of sunshine in Riyadh, Saudi Arabia. Dermatoendocrinol 5(1):177–180PubMedPubMedCentral Alshahrani FM, Almalki MH, Aljohani N, Alzahrani A, Alsaleh Y, Holick MF (2013) Vitamin D light siside and best time of sunshine in Riyadh, Saudi Arabia. Dermatoendocrinol 5(1):177–180PubMedPubMedCentral
31.
go back to reference AlSalman SA, Alkaff TM, Alzaid T, Binamer Y (2018) Nonmelanoma skin cancer in Saudi Arabia: single center experience. Ann Saudi Med 38(1):42–45PubMedPubMedCentral AlSalman SA, Alkaff TM, Alzaid T, Binamer Y (2018) Nonmelanoma skin cancer in Saudi Arabia: single center experience. Ann Saudi Med 38(1):42–45PubMedPubMedCentral
32.
go back to reference Al-Daghri NM, Al-Saleh Y, Khan N, Sabico S, Aljohani N, Alfawaz H, Alsulaimani M, Al-Othman AM, Alokail MS (2016) Sun exposure, skin color and vitamin D status in Arab children and adults. J Steroid Biochem Mol Biol 164:235–238PubMed Al-Daghri NM, Al-Saleh Y, Khan N, Sabico S, Aljohani N, Alfawaz H, Alsulaimani M, Al-Othman AM, Alokail MS (2016) Sun exposure, skin color and vitamin D status in Arab children and adults. J Steroid Biochem Mol Biol 164:235–238PubMed
33.
go back to reference Rizzoli R, Stevenson JC, Bauer JM, van Loon LJ, Walrand S, Kanis JA, Cooper C, Brandi ML, Diez-Perez A, Reginster JY, ESCEO Task Force (2014) The role of dietary protein and vitamin D in maintaining musculoskeletal health in postmenopausal women: a consensus statement from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ECSEO). Maturitas 79(1):122–132PubMed Rizzoli R, Stevenson JC, Bauer JM, van Loon LJ, Walrand S, Kanis JA, Cooper C, Brandi ML, Diez-Perez A, Reginster JY, ESCEO Task Force (2014) The role of dietary protein and vitamin D in maintaining musculoskeletal health in postmenopausal women: a consensus statement from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ECSEO). Maturitas 79(1):122–132PubMed
34.
go back to reference Hwalla N, Al Dhaheri AS, Radwan H, Alfawaz H, Fouda MA, Al-Daghri NM, Zaghloul S, Blumberg JB (2017) The prevalence of micronutrient deficiencies and inadequacies in the Middle East and approaches to interventions. Nutrients 9(3):E229PubMed Hwalla N, Al Dhaheri AS, Radwan H, Alfawaz H, Fouda MA, Al-Daghri NM, Zaghloul S, Blumberg JB (2017) The prevalence of micronutrient deficiencies and inadequacies in the Middle East and approaches to interventions. Nutrients 9(3):E229PubMed
35.
go back to reference Bouillon R, Van Schoor NM, Gielen E, Boonen S, Mathieu C, Vanderschueren D, Lips P (2013) Optimal vitamin D status: a critical analysis on the basis of evidence-based medicine. J Clin Endocrinol Metab 98(8):E1283–E1304PubMed Bouillon R, Van Schoor NM, Gielen E, Boonen S, Mathieu C, Vanderschueren D, Lips P (2013) Optimal vitamin D status: a critical analysis on the basis of evidence-based medicine. J Clin Endocrinol Metab 98(8):E1283–E1304PubMed
36.
go back to reference Chaktoura M, Akl EA, El Ghandour S, Shawwa K, Arabi A, Mahfoud Z, Habib RH, Hoballah H, El Hajj Fuleihan G (2017) Impact of vitamin D replacement in adults and elderly in the Middle East and North Africa: a systematic review and meta-analysis of randomized controlled trials. Osteoporos Int 28(1):35–46 Chaktoura M, Akl EA, El Ghandour S, Shawwa K, Arabi A, Mahfoud Z, Habib RH, Hoballah H, El Hajj Fuleihan G (2017) Impact of vitamin D replacement in adults and elderly in the Middle East and North Africa: a systematic review and meta-analysis of randomized controlled trials. Osteoporos Int 28(1):35–46
37.
go back to reference Chakhtoura M, El Ghandour S, Shawwa K, Akl EA, Arabi A, Mahfoud Z, Habib R, Hoballah H, El Hajj Fuleihan G (2017) Vitamin D replacement in children, adolescents and pregnant women in the Middle East and North Africa: a systematic review and meta-analysis of randomized controlled trials. Metabolism 70:160–176PubMedPubMedCentral Chakhtoura M, El Ghandour S, Shawwa K, Akl EA, Arabi A, Mahfoud Z, Habib R, Hoballah H, El Hajj Fuleihan G (2017) Vitamin D replacement in children, adolescents and pregnant women in the Middle East and North Africa: a systematic review and meta-analysis of randomized controlled trials. Metabolism 70:160–176PubMedPubMedCentral
38.
go back to reference Scragg R, Stewart AW, Waayer D, Lawes CMM, Toop L, Sluyter J, Murphy J, Khaw KT, Camargo CA Jr (2017) Effect of monthly high-dose vitamin D supplementation on cardiovascular disease in the vitamin D assessment study: a randomized clinical trial. JAMA Cardiol 2:608–616PubMedPubMedCentral Scragg R, Stewart AW, Waayer D, Lawes CMM, Toop L, Sluyter J, Murphy J, Khaw KT, Camargo CA Jr (2017) Effect of monthly high-dose vitamin D supplementation on cardiovascular disease in the vitamin D assessment study: a randomized clinical trial. JAMA Cardiol 2:608–616PubMedPubMedCentral
39.
go back to reference Manson JE, Cook NR, Lee IM, Christen W, Bassuk SS, Mora S, Gibson H, Gordon D, Copeland T, D'Agostino D, Friedenberg G, Ridge C, Bubes V, Giovannucci EL, Willett WC, Buring JE, Group VR (2019) Vitamin D supplements and prevention of cancer and cardiovascular disease. N Engl J Med 380(1):33–44PubMed Manson JE, Cook NR, Lee IM, Christen W, Bassuk SS, Mora S, Gibson H, Gordon D, Copeland T, D'Agostino D, Friedenberg G, Ridge C, Bubes V, Giovannucci EL, Willett WC, Buring JE, Group VR (2019) Vitamin D supplements and prevention of cancer and cardiovascular disease. N Engl J Med 380(1):33–44PubMed
40.
go back to reference Khaw KT, Stewart AW, Waayer D, Lawes CMM, Toop L, Camargo CA Jr, Scragg R (2017) Effect of monthly high-dose vitamin D supplementation on falls and non-vertebral fractures: secondary and post-hoc outcomes from the randomized, double-blind, placebo-controlled ViDA trial. Lancet Diabetes Endocrinol 5(6):438–447PubMed Khaw KT, Stewart AW, Waayer D, Lawes CMM, Toop L, Camargo CA Jr, Scragg R (2017) Effect of monthly high-dose vitamin D supplementation on falls and non-vertebral fractures: secondary and post-hoc outcomes from the randomized, double-blind, placebo-controlled ViDA trial. Lancet Diabetes Endocrinol 5(6):438–447PubMed
41.
go back to reference Al-Daghri NM, Mohammed AK, Bukhari I, Rikli M, Abdi S, Ansari MGA, Sabico S, Hussain SD, Alenad AM, Al-Saleh Y, Alokail MS (2019) Efficacy of vitamin D supplementation according to vitamin D binding polymorphisms. Nutrition in-press Al-Daghri NM, Mohammed AK, Bukhari I, Rikli M, Abdi S, Ansari MGA, Sabico S, Hussain SD, Alenad AM, Al-Saleh Y, Alokail MS (2019) Efficacy of vitamin D supplementation according to vitamin D binding polymorphisms. Nutrition in-press
42.
go back to reference Palermo A, Strollo R, Maddaloni E, Tuccinardi D, D’Onofrio L, Briganti SI, Defeudis G, De Pascalis M, Lazzaro MC, Colleluori G, Manfrini S, Pozzilli P, Napoli N (2015) Irisin is associated with osteoporotic fractures independently of bone mineral density, body composition or physical activity. Clin Endocrinol 82(4):615–619 Palermo A, Strollo R, Maddaloni E, Tuccinardi D, D’Onofrio L, Briganti SI, Defeudis G, De Pascalis M, Lazzaro MC, Colleluori G, Manfrini S, Pozzilli P, Napoli N (2015) Irisin is associated with osteoporotic fractures independently of bone mineral density, body composition or physical activity. Clin Endocrinol 82(4):615–619
43.
go back to reference Al-Daghri NM, Alokail MS, Rahman S, Amer OE, Al-Attas OS, Alfawaz H, Tripathi G, Sabico S, Chrousos GP, McTernan PG, Piya MK (2015) Habitual physical activity is associated with circulating irisin in healthy controls but not in subjects with diabetes mellitus type 2. Eur J Clin Investig 45(8):775–781 Al-Daghri NM, Alokail MS, Rahman S, Amer OE, Al-Attas OS, Alfawaz H, Tripathi G, Sabico S, Chrousos GP, McTernan PG, Piya MK (2015) Habitual physical activity is associated with circulating irisin in healthy controls but not in subjects with diabetes mellitus type 2. Eur J Clin Investig 45(8):775–781
44.
go back to reference Cavalier E, Mismetti V, Souberbielle JC (2014) Evaluation of circulating irisin levels in healthy young individuals after a single 100,000 IU vitamin D dose. Ann Endocrinol (Paris) 75(3):162–164 Cavalier E, Mismetti V, Souberbielle JC (2014) Evaluation of circulating irisin levels in healthy young individuals after a single 100,000 IU vitamin D dose. Ann Endocrinol (Paris) 75(3):162–164
45.
go back to reference Dretakis K, Igoumenou VG (2019) The role of parathyroid hormone (PTH) and vitamin D in falls and hip fracture type. Aging Clin Exp Res 31(10):1501–1507PubMed Dretakis K, Igoumenou VG (2019) The role of parathyroid hormone (PTH) and vitamin D in falls and hip fracture type. Aging Clin Exp Res 31(10):1501–1507PubMed
46.
go back to reference Xia W, Cooper C, Li M, Xu L, Rizzoli R, Zhu M, Lin H, Beard J, Ding Y, Yu W, Cavalier E, Zhang Z, Kanis JA, Cheng Q, Wang Q, Reginster JY (2019) East meets West: current practices and policies in the management of musculoskeletal aging. Aging Clin Exp Res 31(10):1351–1373PubMedPubMedCentral Xia W, Cooper C, Li M, Xu L, Rizzoli R, Zhu M, Lin H, Beard J, Ding Y, Yu W, Cavalier E, Zhang Z, Kanis JA, Cheng Q, Wang Q, Reginster JY (2019) East meets West: current practices and policies in the management of musculoskeletal aging. Aging Clin Exp Res 31(10):1351–1373PubMedPubMedCentral
47.
go back to reference Neale RE, Armstrong BK, Baxter C, Duarte Romero B, Ebeling P, English DR, Kimlin MG, McLeaod DS, RL OC, van der Pols JC, Venn AJ, Webb PM, Whiteman DC, Wockner L (2016) The D-Health Trial: a randomized trial of vitamin D for prevention of mortality and cancer. Contemp Clin Trials 48:83–90PubMed Neale RE, Armstrong BK, Baxter C, Duarte Romero B, Ebeling P, English DR, Kimlin MG, McLeaod DS, RL OC, van der Pols JC, Venn AJ, Webb PM, Whiteman DC, Wockner L (2016) The D-Health Trial: a randomized trial of vitamin D for prevention of mortality and cancer. Contemp Clin Trials 48:83–90PubMed
48.
go back to reference Bassuk SS, Manson JE, Lee IM, Cok NR, Christen WG, Bubes VY, Gordon DS, Copeland T, Friedenberg G, D'Agostino DM, Ridge CY, MacFadyen JG, Kalan K, Buring JE (2016) Baseline characteristics of participants in the VITamin D and OmegA-3 Trial (VITAL). Contemp Clin Trials 47:235–243PubMedPubMedCentral Bassuk SS, Manson JE, Lee IM, Cok NR, Christen WG, Bubes VY, Gordon DS, Copeland T, Friedenberg G, D'Agostino DM, Ridge CY, MacFadyen JG, Kalan K, Buring JE (2016) Baseline characteristics of participants in the VITamin D and OmegA-3 Trial (VITAL). Contemp Clin Trials 47:235–243PubMedPubMedCentral
Metadata
Title
Diagnosis and management of vitamin D deficiency in the Gulf Cooperative Council (GCC) countries: an expert consensus summary statement from the GCC vitamin D advisory board
Authors
Yousef Al Saleh
Salem A. Beshyah
Wiam Hussein
Abdulrazzaq Almadani
Ahmed Hassoun
Ali Al Mamari
Ebtesam Ba-Essa
Essa Al-Dhafiri
Mohammed Hassanein
Mona A. Fouda
Nadia Al Ali
Naji Aljohani
Nasreen Al-Sayed
Neil Gittoes
Tarik Elhadd
Waleed Al-Baker
Shaun Sabico
Nasser Al-Daghri
Publication date
01-12-2020
Publisher
Springer London
Published in
Archives of Osteoporosis / Issue 1/2020
Print ISSN: 1862-3522
Electronic ISSN: 1862-3514
DOI
https://doi.org/10.1007/s11657-020-0709-8

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