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Archives of Osteoporosis

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01-12-2018 | Original Article

Microstructural properties of trabecular bone autografts: comparison of men and women with and without osteoporosis

Authors: Fen Xie, Bin Zhou, Jian Wang, Tang Liu, Xiyu Wu, Rui Fang, Yijun Kang, Ruchun Dai

Published in: Archives of Osteoporosis | Issue 1/2018

Abstract

Summary

The microstructure of autologous bone grafts from men over 50 years old and postmenopausal women undergoing spinal fusion were evaluated using micro-CT. We demonstrated postmenopausal women, especially those with osteoporosis (OP) presented more serious microarchitectural deterioration of bone grafts.

Purpose

This study was undertaken to determine microstructural properties of cancellous bone used as autologous bone grafts from osteoporosis patients undergoing lumbar fusion by comparing microstructural indices to controls.

Methods

Cancellous bone specimens from spinous processes were obtained from 41 postmenopausal women (osteoporosis women, n = 19; controls, n = 22) and 26 men over 50 years old (osteoporosis men, n = 8; controls, n = 18) during lumbar fusion surgery. The microstructural parameters were measured using micro-CT.

Results

Significant difference in bone volume fraction (BV/TV), specific bone surface (BS/BV), trabecular thickness (Tb.Th), and structure model index (SMI) value existed between postmenopausal women with OP and controls. Significant difference in trabecular number (Tb.N) existed between men over 50 years old with OP and controls. Postmenopausal women exhibited lower BV/TV, Tb.Th, and higher SMI value than men over 50 years old. Postmenopausal women with OP exhibited lower BV/TV, Tb.Th, and higher BS/BV than men over 50 years old with OP.

Conclusions

Post-menopausal women and older men with OP have worse bone quality in autografts than non-osteoporotic men and women. Postmenopausal women with OP presented serious microarchitectural deterioration in older population

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Title: Microstructural properties of trabecular bone autografts: comparison of men and women with and without osteoporosis
Authors: Fen Xie
Bin Zhou
Jian Wang
Tang Liu
Xiyu Wu
Rui Fang
Yijun Kang
Ruchun Dai
Publication date: 01-12-2018
Publisher: Springer London
Published in: Archives of Osteoporosis / Issue 1/2018
Print ISSN: 1862-3522
Electronic ISSN: 1862-3514
DOI: https://doi.org/10.1007/s11657-018-0422-z

At a glance: The STEP trials

Springer Medicine

Microstructural properties of trabecular bone autografts: comparison of men and women with and without osteoporosis

Abstract

Summary

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Summary

Purpose

Methods

Results

Conclusions

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