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Archives of Osteoporosis

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01-12-2017 | Short Communication

A weekly 35,000 IU vitamin D supplementation improves bone turnover markers in vitamin D deficient Saudi adolescent females

Authors: Riad A. Sulimani, Ashry G. Mohammed, Suliman N. Alshehri, Assim A. Alfadda, Abdulaziz Al-Othman, Aliya A. Khan

Published in: Archives of Osteoporosis | Issue 1/2017

Abstract

Summary

This study examined the effects of weekly 35,000 IU vitamin D supplementation for 4 weeks on bone turnover markers (BTMs). There was improvement in the levels of parathyroid hormone (PTH), osteocalcin, and carboxy-terminal telopeptides of crosslinks of type 1 collagen (βCTX) which paralleled the increase in vitamin D levels.

Purpose

The effects of vitamin D supplementation on bone turnover markers (BTMs) have been inconsistent. This study examined the effects of weekly 35,000 IU vitamin D supplementation for 1 month on BTMs.

Methods

Sixty-eight vitamin D deficient adolescent females were given 35,000 IU of vitamin D3 for 4 weeks. Pre and post intervention blood samples were taken for 25(OH) D, PTH, osteocalcin and βCTX.

Results

There was a significant increase in serum 25 (OH) D in the post intervention period which was accompanied by a significant decrease in PTH, osteocalcin and βCTX (P < 0.001).

Conclusions

We concluded that weekly 35,000 IU vitamin D supplementation for 4 weeks results in significant improvement of BTMs.

Al-Daghri NM (2016) Vitamin D in Saudi Arabia: Prevalence, distribution and disease associations. J Steroid Biochem Mol Biol. (3)

Bassil D, Rahme M, Hoteit M, El-Hajj FG (2013) Hypovitaminosis D in the Middle East and North Africa. Dermato-Endocrinology 5:274–298CrossRefPubMedPubMedCentral

Gallagher JC, Sai A, Templin T, Smith L (2012) Dose response to vitamin D supplementation in postmenopausal women: a randomized trial. Ann Intern Med 156:425–437CrossRefPubMed

Mortensen C, Damsgaard CT, Hauger H, Ritz C, Lanham-New SA, Smith TJ, Hennessy A, Dowling K, Cashman KD, Kiely M, Molgaard C (2016) Estimation of the dietary requirement for vitamin D in white children aged 4-8 y: a randomized, controlled, dose-response trial. Am J Clin Nutr 104:1310–1317CrossRefPubMed

Cashman KD, Dowling KG, Škrabáková Z, Gonzalez-Gross M, Valtueña J, De Henauw S et al (2016) Vitamin D deficiency in Europe: pandemic? Am J Clin Nutr 103:1033–1044 (1)CrossRefPubMedPubMedCentral

Smith TJ, Tripkovic L, Damsgaard CT, Molgaard C, Ritz C, Wilson-Barnes SL, Dowling KG, Hennessy A, Cashman KD, Kiely M, Lanham-New SA, Hart KH (2016) Estimation of the dietary requirement for vitamin D in adolescents aged 14-18 y: a dose-response, double-blind, randomized placebo-controlled trial. Am J Clin Nutr 104:1301–1309CrossRefPubMed

Rimm EB, Giovannucci EL, Stampfer MJ, Colditz GA, Litin LB, Willett WC (1992) Reproducibility and validity of an expanded self-administered semiquantitative food frequency questionnaire among male health professionals. Am J Epidemiol 135:1114–1126CrossRefPubMed

Al-Disi D, Al-Daghri N, Khanam L, Al-Othman A, Al-Saif M, Sabico S, Chrousos G (2010) Subjective sleep duration and quality influence diet composition and circulating adipocytokines and ghrelin levels in teen-age girls. Endocr J 57:915–923CrossRefPubMed

Al-Daghri NM, Al-Saleh Y, Ajohani N, Sulimani R, Al-Othman AM, Alfawaz H, Fouda M, Al-Amri F, Shahrani A, Alharbi M, Alshahrani F, Tamimi W, Sabico S, Rizzoli R, Reginster JY (2017) Vitamin D status correction in Saudi Arabia: an experts’ consensus under the auspices of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis, and Muskuloskeletal Diseases (ESCEO). Arch Osteoporos 12(1):1 (5)CrossRefPubMed

10.

Sulimani RA, Ashry G, Alfadda A, Alshehri S, Al-Othman A, Al-Daghri N, Hanley D, Khan A (2016) Vitamin D deficiency and biochemical variations among urban Saudi adolescent girls according to season. Saud Med J 37(9):1002 (4)CrossRef

11.

Andersen R, Molgaard C, Skovgaar LT, Brot C, Cashman KD, Jacobsen J, Allardt CL, Ovesen L (2008) Effect of Vitamin D Supplementation on bone and vitamin D status among Pakistani immigrants in Denmark: a randomised double blinded placebo-controlled intervention study. Br J Nutr 100:197–207 (6)

12.

Molgaard C, Larnkjaer A, Cashman KD, Lamberg-Allardt C, Jakobsen J, Michaelson KF (2010) Does Vitamin D supplementation of healthy Danish Caucasian girls affect bone turnover and bone mineralization? Bone 46(2):432–439 (7)CrossRefPubMed

13.

Zhu K, Bruce D, Austin N, Devine A, Ebeling PR, Prince RL (2008) Randomized controlled trial of the effects of calcium with or without vitamin D on bone structure and bone related chemistry in elderly women with vitamin D insufficiency. J Bone Miner Res 23(8):1343–1348 (8)CrossRefPubMed

14.

Holvik K, Madar AA, Meyer HE, Lofthus CM, Stene LC (2012) Changes in the vitamin D endocrine system and bone turnover after oral vitamin D3 supplementation in health adults: results of a randomised trial. BMC Endocr Disord 12:7 (9)CrossRefPubMedPubMedCentral

15.

Piso RJ, Rothen M, Rothen JP, Stahl M, Fux C (2013) Per oral substitution with 300000 IU vitamin D (Cholecalciferol) reduces bone turnover marker in HIV-infected patients. BMC Infect Dis 13:577 (10)CrossRefPubMedPubMedCentral

16.

Meier C, Woitge HW, Witte K, Lemmer B, Seibel MJ (2004) Supplementation with oral vitamin D3 and calcium during winter prevents seasonal bone loss: a randomized controlled open-label prospective trial. J Bone Miner Res 19(8):1221–30

17.

Zubillaga P, Garrido A, Mugica I, Ansa J, Zabalaza R, Emparnza JI (2006) Effect of vitamin D and calcium supplementation on bone turnover in institutionalized adults with Down's Syndrome. Eur J Clin Nutr 60:605–609

Title: A weekly 35,000 IU vitamin D supplementation improves bone turnover markers in vitamin D deficient Saudi adolescent females
Authors: Riad A. Sulimani
Ashry G. Mohammed
Suliman N. Alshehri
Assim A. Alfadda
Abdulaziz Al-Othman
Aliya A. Khan
Publication date: 01-12-2017
Publisher: Springer London
Published in: Archives of Osteoporosis / Issue 1/2017
Print ISSN: 1862-3522
Electronic ISSN: 1862-3514
DOI: https://doi.org/10.1007/s11657-017-0379-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

A weekly 35,000 IU vitamin D supplementation improves bone turnover markers in vitamin D deficient Saudi adolescent females

Abstract

Summary

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Summary

Purpose

Methods

Results

Conclusions

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