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Published in: Archives of Osteoporosis 1/2017

01-12-2017 | Original Article

Vitamin D deficiency in older adults and its associated factors: a cross-sectional analysis of the Mexican Health and Aging Study

Authors: María Fernanda Carrillo-Vega, Carmen García-Peña, Luis Miguel Gutiérrez-Robledo, Mario Ulises Pérez-Zepeda

Published in: Archives of Osteoporosis | Issue 1/2017

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Abstract

Summary

Vitamin D deficiency was common in older adults from a country with adequate sun exposure. The variables associated with this deficiency provide insight into the next steps needed to characterize older adults with this deficiency and to treat it accordingly.

Purpose

The aim of this study was to describe the prevalence of and factors associated with vitamin D deficiency among Mexican older adults.

Methods

This was a secondary analysis of the last wave of the Mexican Health and Aging Study. Vitamin D levels along with other biomarkers were obtained from a sub-sample of Mexican adults older than 60 years. Prevalence was described by sex and age group, and a multivariate analysis was performed to test the factors associated with this condition.

Results

Data from 1088 adults over the age of 60 years were analyzed. The mean serum vitamin D level was 23.1 ± 8.1 ng/mL and was significantly higher among men than women (25.6 ± 0.6 and 22.8 ± 0.5 ng/mL, respectively; p < 0.001). In total, 37.3% (n = 406) presented with vitamin D deficiency, 65% of whom were women. Low 25-(OH)-vitamin D levels were associated with female sex (OR 1.74, 95% CI 1.59–2.42), current smoking (OR 2.21, 95% CI 1.47–3.39), education (OR 1.1, 95% CI 1.06–1.13), physical activity (OR 1.74, 95% CI 1.31–2.23), and high levels of glycated hemoglobin (OR 1.16, 95% CI 1.07–1.25).

Conclusions

Vitamin D deficiency was highly prevalent in Mexican older adults and was associated with a number of factors, indicating the multifactorial causality of this deficiency.
Literature
3.
go back to reference Klenk J, Rapp K, Denkinger MD, Nagel G, Nikolaus T, Peter R, Koenig W, Bohm BO, Rothenbacher D (2013) Seasonality of vitamin D status in older people in Southern Germany: implications for assessment. Age Ageing 42:404–408. doi:10.1093/ageing/aft042 CrossRefPubMed Klenk J, Rapp K, Denkinger MD, Nagel G, Nikolaus T, Peter R, Koenig W, Bohm BO, Rothenbacher D (2013) Seasonality of vitamin D status in older people in Southern Germany: implications for assessment. Age Ageing 42:404–408. doi:10.​1093/​ageing/​aft042 CrossRefPubMed
6.
go back to reference Durvasula S, Gies P, Mason RS, Chen JS, Henderson S, Seibel MJ, Sambrook PN, March LM, Lord SR, Kok C, Macara M, Parmenter TR, Cameron ID (2014) Vitamin D response of older people in residential aged care to sunlight-derived ultraviolet radiation. Arch Osteoporos 9:197. doi:10.1007/s11657-014-0197-9 CrossRefPubMed Durvasula S, Gies P, Mason RS, Chen JS, Henderson S, Seibel MJ, Sambrook PN, March LM, Lord SR, Kok C, Macara M, Parmenter TR, Cameron ID (2014) Vitamin D response of older people in residential aged care to sunlight-derived ultraviolet radiation. Arch Osteoporos 9:197. doi:10.​1007/​s11657-014-0197-9 CrossRefPubMed
7.
8.
go back to reference Palacios C, González L (2014) La deficiencia de vitamina D es un problema global de salud pública. An Venez Nutr 27:57–72 Palacios C, González L (2014) La deficiencia de vitamina D es un problema global de salud pública. An Venez Nutr 27:57–72
10.
go back to reference Wong R, Michaels-Obregon A, Palloni A, Gutierrez-Robledo LM, Gonzalez-Gonzalez C, Lopez-Ortega M, Tellez-Rojo MM, Mendoza-Alvarado LR (2015) Progression of aging in Mexico: the Mexican Health and Aging Study (MHAS) 2012. Salud Publica Mex 57(Suppl 1):S79–S89CrossRefPubMedPubMedCentral Wong R, Michaels-Obregon A, Palloni A, Gutierrez-Robledo LM, Gonzalez-Gonzalez C, Lopez-Ortega M, Tellez-Rojo MM, Mendoza-Alvarado LR (2015) Progression of aging in Mexico: the Mexican Health and Aging Study (MHAS) 2012. Salud Publica Mex 57(Suppl 1):S79–S89CrossRefPubMedPubMedCentral
11.
12.
go back to reference Aguilar-Navarro SG, Fuentes-Cantu A, Avila-Funes JA, Garcia-Mayo EJ (2007) Validity and reliability of the screening questionnaire for geriatric depression used in the Mexican Health and Age Study. Salud Publica Mex 49:256–262CrossRefPubMed Aguilar-Navarro SG, Fuentes-Cantu A, Avila-Funes JA, Garcia-Mayo EJ (2007) Validity and reliability of the screening questionnaire for geriatric depression used in the Mexican Health and Age Study. Salud Publica Mex 49:256–262CrossRefPubMed
14.
go back to reference Flores M, Sánchez-Romero LM, Macías N, Lozada A, Díaz E, Barquera S (2011) Concentraciones séricas de vitamina D en niños, adolescentes y adultos mexicanos. . In (Mexico) INdSP (ed) Resultados de la ENSANUT 2006. Secretaría de Salud, Cuernavaca, México Flores M, Sánchez-Romero LM, Macías N, Lozada A, Díaz E, Barquera S (2011) Concentraciones séricas de vitamina D en niños, adolescentes y adultos mexicanos. . In (Mexico) INdSP (ed) Resultados de la ENSANUT 2006. Secretaría de Salud, Cuernavaca, México
15.
go back to reference Daly RM, Gagnon C, ZX L, Magliano DJ, Dunstan DW, Sikaris KA, Zimmet PZ, Ebeling PR, Shaw JE (2012) Prevalence of vitamin D deficiency and its determinants in Australian adults aged 25 years and older: a national, population-based study. Clin Endocrinol 77:26–35. doi:10.1111/j.1365-2265.2011.04320.x CrossRef Daly RM, Gagnon C, ZX L, Magliano DJ, Dunstan DW, Sikaris KA, Zimmet PZ, Ebeling PR, Shaw JE (2012) Prevalence of vitamin D deficiency and its determinants in Australian adults aged 25 years and older: a national, population-based study. Clin Endocrinol 77:26–35. doi:10.​1111/​j.​1365-2265.​2011.​04320.​x CrossRef
17.
go back to reference Bischoff-Ferrari HA, Giovannucci E, Willett WC, Dietrich T, Dawson-Hughes B (2006) Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr 84:18–28PubMed Bischoff-Ferrari HA, Giovannucci E, Willett WC, Dietrich T, Dawson-Hughes B (2006) Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr 84:18–28PubMed
18.
go back to reference Portela ML, Mónico A, Barahona A, Dupraz H, Sol Gonzales-Chaves MM, Zeni SN (2010) Comparative 25-OH-vitamin D level in institutionalized women older than 65 years from two cities in Spain and Argentina having a similar solar radiation index. Nutrition 26:283–289. doi:10.1016/j.nut.2009.04.022 CrossRefPubMed Portela ML, Mónico A, Barahona A, Dupraz H, Sol Gonzales-Chaves MM, Zeni SN (2010) Comparative 25-OH-vitamin D level in institutionalized women older than 65 years from two cities in Spain and Argentina having a similar solar radiation index. Nutrition 26:283–289. doi:10.​1016/​j.​nut.​2009.​04.​022 CrossRefPubMed
19.
go back to reference Mateo-Pascual C, Julián-Viñals R, Alarcón-Alarcón T, Castell-Alcalá MV, Iturzaeta-Sánchez JM, Otero-Piume A (2014) Vitamin D deficiency in a cohort over 65 years: prevalence and association with sociodemographic and health factors. Rev Esp Geriatr Gerontol 49:210–216. doi:10.1016/j.regg.2013.11.004 CrossRefPubMed Mateo-Pascual C, Julián-Viñals R, Alarcón-Alarcón T, Castell-Alcalá MV, Iturzaeta-Sánchez JM, Otero-Piume A (2014) Vitamin D deficiency in a cohort over 65 years: prevalence and association with sociodemographic and health factors. Rev Esp Geriatr Gerontol 49:210–216. doi:10.​1016/​j.​regg.​2013.​11.​004 CrossRefPubMed
20.
go back to reference McCarroll K, Beirne A, Casey M, McNulty H, Ward M, Hoey L, Molloy A, Laird E, Healy M, Strain JJ, Cunningham C (2015) Determinants of 25-hydroxyvitamin D in older Irish adults. Age Ageing 44:847–853. doi:10.1093/ageing/afv090 CrossRefPubMed McCarroll K, Beirne A, Casey M, McNulty H, Ward M, Hoey L, Molloy A, Laird E, Healy M, Strain JJ, Cunningham C (2015) Determinants of 25-hydroxyvitamin D in older Irish adults. Age Ageing 44:847–853. doi:10.​1093/​ageing/​afv090 CrossRefPubMed
21.
go back to reference Oliveri B, Plantalech L, Bagur A, Wittich AC, Rovai G, Pusiol E, López Giovanelli J, Ponce G, Nieva A, Chaperón A, Ladizesky M, Somoza J, Casco C, Zeni S, Parisi MS, Mautalen CA (2004) High prevalence of vitamin D insufficiency in healthy elderly people living at home in Argentina. Eur J Clin Nutr 58:337–342. doi:10.1038/sj.ejcn.1601786 CrossRefPubMed Oliveri B, Plantalech L, Bagur A, Wittich AC, Rovai G, Pusiol E, López Giovanelli J, Ponce G, Nieva A, Chaperón A, Ladizesky M, Somoza J, Casco C, Zeni S, Parisi MS, Mautalen CA (2004) High prevalence of vitamin D insufficiency in healthy elderly people living at home in Argentina. Eur J Clin Nutr 58:337–342. doi:10.​1038/​sj.​ejcn.​1601786 CrossRefPubMed
22.
go back to reference Linnebur SA, Vondracek SF, Vande Griend JP, Ruscin JM, McDermott MT (2007) Prevalence of vitamin D insufficiency in elderly ambulatory outpatients in Denver, Colorado. Am J Geriatr Pharmacother 5:1–8CrossRefPubMed Linnebur SA, Vondracek SF, Vande Griend JP, Ruscin JM, McDermott MT (2007) Prevalence of vitamin D insufficiency in elderly ambulatory outpatients in Denver, Colorado. Am J Geriatr Pharmacother 5:1–8CrossRefPubMed
23.
go back to reference Choi EY (2012) 25(OH)D status and demographic and lifestyle determinants of 25(OH)D among Korean adults. Asia Pac J Clin Nutr 21:526–535PubMed Choi EY (2012) 25(OH)D status and demographic and lifestyle determinants of 25(OH)D among Korean adults. Asia Pac J Clin Nutr 21:526–535PubMed
24.
go back to reference Vieth R, Ladak Y, Walfish PG (2003) Age-related changes in the 25-hydroxyvitamin D versus parathyroid hormone relationship suggest a different reason why older adults require more vitamin D. J Clin Endocrinol Metab 88:185–191. doi:10.1210/jc.2002-021064 CrossRefPubMed Vieth R, Ladak Y, Walfish PG (2003) Age-related changes in the 25-hydroxyvitamin D versus parathyroid hormone relationship suggest a different reason why older adults require more vitamin D. J Clin Endocrinol Metab 88:185–191. doi:10.​1210/​jc.​2002-021064 CrossRefPubMed
26.
go back to reference Semba RD, Garrett E, Johnson BA, Guralnik JM, Fried LP (2000) Vitamin D deficiency among older women with and without disability. Am J Clin Nutr 72:1529–1534PubMed Semba RD, Garrett E, Johnson BA, Guralnik JM, Fried LP (2000) Vitamin D deficiency among older women with and without disability. Am J Clin Nutr 72:1529–1534PubMed
27.
go back to reference Hirani V, Cumming RG, Le Couteur DG, Naganathan V, Blyth F, Handelsman DJ, Waite LM, Seibel MJ (2014) Low levels of 25-hydroxy vitamin D and active 1,25-dihydroxyvitamin D independently associated with type 2 diabetes mellitus in older Australian men: the Concord Health and Ageing in Men Project. J Am Geriatr Soc 62:1741–1747. doi:10.1111/jgs.12975 CrossRefPubMed Hirani V, Cumming RG, Le Couteur DG, Naganathan V, Blyth F, Handelsman DJ, Waite LM, Seibel MJ (2014) Low levels of 25-hydroxy vitamin D and active 1,25-dihydroxyvitamin D independently associated with type 2 diabetes mellitus in older Australian men: the Concord Health and Ageing in Men Project. J Am Geriatr Soc 62:1741–1747. doi:10.​1111/​jgs.​12975 CrossRefPubMed
30.
32.
go back to reference Fuleihan GE, Bouillon R, Clarke B, Chakhtoura M, Cooper C, McClung M, Singh RJ (2015) Serum 25-hydroxyvitamin D levels: variability, knowledge gaps, and the concept of a desirable range. J Bone Miner Res 30:1119–1133. doi:10.1002/jbmr.2536 CrossRef Fuleihan GE, Bouillon R, Clarke B, Chakhtoura M, Cooper C, McClung M, Singh RJ (2015) Serum 25-hydroxyvitamin D levels: variability, knowledge gaps, and the concept of a desirable range. J Bone Miner Res 30:1119–1133. doi:10.​1002/​jbmr.​2536 CrossRef
Metadata
Title
Vitamin D deficiency in older adults and its associated factors: a cross-sectional analysis of the Mexican Health and Aging Study
Authors
María Fernanda Carrillo-Vega
Carmen García-Peña
Luis Miguel Gutiérrez-Robledo
Mario Ulises Pérez-Zepeda
Publication date
01-12-2017
Publisher
Springer London
Published in
Archives of Osteoporosis / Issue 1/2017
Print ISSN: 1862-3522
Electronic ISSN: 1862-3514
DOI
https://doi.org/10.1007/s11657-016-0297-9

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