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01-12-2016 | Original Article

Differences in the trajectory of bone mineral density change measured at the total hip and femoral neck between men and women following hip fracture

Authors: Alan M. Rathbun, Michelle Shardell, Denise Orwig, J. Richard Hebel, Gregory E. Hicks, Thomas Beck, Marc C. Hochberg, Jay Magaziner

Published in: Archives of Osteoporosis | Issue 1/2016

Abstract

Summary

Research has not examined changes in bone mineral density (BMD) between men and women following hip fracture. The aim was to evaluate sex differences in BMD following hip fracture. Men experienced significant declines in BMD, while not statistically greater than women, underscoring the necessity for better osteoporosis care in men.

Introduction

Each year in the USA, approximately 260,000 older adults experience a hip fracture. Women experiencing hip fracture have excess decline in BMD in the year following fracture compared to expected decrements due to aging, but few studies have assessed sex differences in the sequelae of hip fracture. Thus, our objective was to examine sex differences in BMD change in the year after hip fracture.

Methods

The sample (n = 286) included persons enrolled in the Baltimore Hip Studies 7th cohort, a study that matched (1:1) men and women experiencing hip fracture. Weighted estimating equations that accounted for missing data and selective survival were used to estimate sex differences in 12-month total hip (TH) and femoral neck (FN) BMD changes.

Results

Men had larger average adjusted percent decline in TH and FN BMD. Adjusted 12-month decreases at the FN showed a statistically significant decline of −4.60 % (95 % confidence interval [CI] −7.76 %, −0.20 %) in men and an insignificant change of −1.62 % (95 % CI −4.57 %, 1.32 %) in women. Yet, the difference in change between men and women was not statistically significant (P = 0.17). The estimated sex differences for TH BMD loss were smaller in magnitude.

Conclusions

There is evidence of significant BMD loss among men at the FN in the year after hip fracture. Although not statistically greater than women, these clinically significant findings highlight the need for improved osteoporosis care among men prior to and after hip fracture.

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Title: Differences in the trajectory of bone mineral density change measured at the total hip and femoral neck between men and women following hip fracture
Authors: Alan M. Rathbun
Michelle Shardell
Denise Orwig
J. Richard Hebel
Gregory E. Hicks
Thomas Beck
Marc C. Hochberg
Jay Magaziner
Publication date: 01-12-2016
Publisher: Springer London
Published in: Archives of Osteoporosis / Issue 1/2016
Print ISSN: 1862-3522
Electronic ISSN: 1862-3514
DOI: https://doi.org/10.1007/s11657-016-0263-6

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Differences in the trajectory of bone mineral density change measured at the total hip and femoral neck between men and women following hip fracture

Abstract

Summary

Introduction

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusions

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