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Journal of Gastrointestinal Surgery

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01-09-2019 | Metastasis | Original Article

Soft-Tissue Metastases From Esophageal Cancer

Authors: Jad M. El Abiad, Russell K. Hales, Adam S. Levin, Carol D. Morris

Published in: Journal of Gastrointestinal Surgery | Issue 9/2019

Abstract

Background

Metastatic carcinoma to skeletal muscle and/or subcutaneous fat is a rare event. Only 27 cases of esophageal cancer to soft tissue have been described in the English-language literature.

Purpose

Our goal was to describe the prevalence and clinical characteristics of soft-tissue metastasis among patients with primary esophageal cancer at a single institution.

Methods

We performed a retrospective review of all patients with primary esophageal cancer. Data points analyzed included histologic subtype, anatomic location, metastasis pattern, treatment, and survival. Kaplan-Meier curves were used to estimate survival time, and log-rank tests were used for comparisons. For all analyses, P < 0.05 was considered significant.

Results

Of 1341 patients with primary esophageal cancer, 25 (1.9%) had metastases to soft tissue. Soft-tissue metastases were diagnosed at a median age of 64 years, a median 9.6 months after esophageal cancer diagnosis. Adenocarcinoma was the predominant histopathological type, and soft-tissue metastasis was most common in the lower extremity. Local intervention was used for 10 symptomatic patients with favorable prognoses. Chemotherapy was the only treatment modality in 18 patients. Median survival time after diagnosis of soft-tissue metastasis was 8.9 months and was longer in patients with metastasis in soft tissue only (24.6 months, P = 0.007) and in those who received local intervention (11.1 months vs those who did not, P = 0.020).

Conclusion

We estimate the prevalence of soft-tissue metastasis to be 1.9% among patients with esophageal cancer. Local intervention may be beneficial for patients in otherwise good health with symptomatic soft-tissue lesions.

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Title: Soft-Tissue Metastases From Esophageal Cancer
Authors: Jad M. El Abiad
Russell K. Hales
Adam S. Levin
Carol D. Morris
Publication date: 01-09-2019
Publisher: Springer US
Keywords: Metastasis
Esophageal Cancer
Esophageal Cancer
Published in: Journal of Gastrointestinal Surgery / Issue 9/2019
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-019-04160-w

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Soft-Tissue Metastases From Esophageal Cancer

Abstract

Background

Purpose

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Purpose

Methods

Results

Conclusion

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