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Journal of Gastrointestinal Surgery
Published in: Journal of Gastrointestinal Surgery 12/2018

01-12-2018 | Original Article

Association Between Juxtapapillary Duodenal Diverticula and Risk of Choledocholithiasis: a Systematic Review and Meta-analysis

Authors: Karn Wijarnpreecha, Panadeekarn Panjawatanan, Wuttiporn Manatsathit, Wisit Cheungpasitporn, Surakit Pungpapong, Frank J. Lukens, Patompong Ungprasert

Published in: Journal of Gastrointestinal Surgery | Issue 12/2018

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Abstract

Background/Objectives

Studies have suggested that the presence of juxtapapillary duodenal diverticula (JDD) could be a predisposing factor for choledocholithiasis. This systematic review and meta-analysis was conducted with the aims to summarize all available evidence to better characterize the risk.

Methods

A literature search was performed using MEDLINE and EMBASE database from inception to January 2018. Cross-sectional studies that reported odd ratios (OR) comparing the risk of choledocholithiasis among individuals with JDD versus individuals without JDD were included. Pooled OR and 95% confidence interval (CI) were calculated using a random-effect, generic inverse variance method.

Results

Of 527 retrieved articles, 11 studies met our eligibility criteria and were included in analysis. We found a significant association between the presence of JDD and choledocholithiasis with the pooled OR of 2.30 (95% CI, 1.84–2.86). The statistical heterogeneity was moderate with an I2 of 60%.

Conclusions

A significantly increased risk of choledocholithiasis among individuals with JDD was observed in this study.
Appendix
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Metadata
Title
Association Between Juxtapapillary Duodenal Diverticula and Risk of Choledocholithiasis: a Systematic Review and Meta-analysis
Authors
Karn Wijarnpreecha
Panadeekarn Panjawatanan
Wuttiporn Manatsathit
Wisit Cheungpasitporn
Surakit Pungpapong
Frank J. Lukens
Patompong Ungprasert
Publication date
01-12-2018
Publisher
Springer US
Published in
Journal of Gastrointestinal Surgery / Issue 12/2018
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI
https://doi.org/10.1007/s11605-018-3865-z

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