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Journal of Gastrointestinal Surgery

Published in:

01-07-2018 | Original Article

Predictive Nomograms for Synchronous Distant Metastasis in Rectal Cancer

Authors: Apostolos Gaitanidis, Michail Alevizakos, Alexandra Tsaroucha, Christos Tsalikidis, Michail Pitiakoudis

Published in: Journal of Gastrointestinal Surgery | Issue 7/2018

Abstract

Background

Nomograms may be used to quantitatively assess the probability of synchronous distant metastasis. The purpose of this study is to develop predictive nomograms for the presence of synchronous distant metastasis in patients with rectal cancer.

Methods

A retrospective analysis of the Surveillance Epidemiology and End Results database was performed for cases diagnosed between 2010 and 2014.

Results

Overall, 46,785 patients with rectal cancer (27,773 [59.4%] males, mean age 63.9 ± 13.7 years) were identified, of which 6192 (13.2%) had liver metastasis, 2767 (5.9%) had lung metastasis, and 601 (1.3%) had bone metastasis. Age, sex, race, tumor location, tumor grade, primary tumor size, CEA levels, perineural invasion, T stage, N stage, and liver and lung metastasis were found to be associated with the presence of synchronous distant metastasis and were included in the predictive models. The c-indexes of these models were 0.99 for liver metastasis, 0.99 for lung metastasis, and 1 for bone metastasis.

Conclusions

Predictive nomograms for the presence of synchronous liver, lung, and bone metastasis were developed and may be used to predict the probability of distant disease in rectal cancer patients.

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Title: Predictive Nomograms for Synchronous Distant Metastasis in Rectal Cancer
Authors: Apostolos Gaitanidis
Michail Alevizakos
Alexandra Tsaroucha
Christos Tsalikidis
Michail Pitiakoudis
Publication date: 01-07-2018
Publisher: Springer US
Published in: Journal of Gastrointestinal Surgery / Issue 7/2018
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-018-3767-0

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Predictive Nomograms for Synchronous Distant Metastasis in Rectal Cancer

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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