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01-04-2018 | 2017 SSAT Plenary Presentation

Incidence, Survival, and Predictors of Lymph Node Involvement in Early-Stage Gastric Signet Ring Cell Carcinoma in the US

Authors: Sridevi K. Pokala, Chao Zhang, Zhengjia Chen, Anthony M. Gamboa, Sarah L. Cristofaro, Steven A. Keilin, Qiang Cai, Field F. Willingham

Published in: Journal of Gastrointestinal Surgery | Issue 4/2018

Abstract

Introduction

The incidence, survival, and propensity for nodal metastasis in early-stage gastric signet ring cell carcinoma have not been defined in the United States. These data are critical determinants for treatment allocation.

Methods

Cases of gastric signet ring cell carcinoma were extracted from the national SEER database for the years 2004–2013. Age-standardized incidence was derived. Survival was calculated using the Kaplan-Meier method. Univariate and multivariate analyses were performed to identify predictors of nodal metastasis. Exclusion criteria included neoadjuvant radiotherapy and lack of histologic or nodal data.

Results

A total of 10,624 cases were initially identified. The analysis cohort included 506 cases with early T-stage N0M0 disease following exclusions. The incidence was 0.094 per 100,000 person-years. The 5-year survival rate was 82.8%. Tumor stage (p < 0.001) and size (p < 0.001) were independent predictors of nodal metastasis. The incidence of nodal involvement for T1a tumors <2 cm was 5.4% (p < 0.004).

Conclusion

The incidence of potentially resectable signet ring gastric carcinoma has not changed significantly over the past decade. While presenting with predominantly high-grade histology, early T-stage disease has a high survival rate. Small T1a tumors have low rates of nodal metastasis, suggesting that an endoscopic resection could be considered in this subset.

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Title: Incidence, Survival, and Predictors of Lymph Node Involvement in Early-Stage Gastric Signet Ring Cell Carcinoma in the US
Authors: Sridevi K. Pokala
Chao Zhang
Zhengjia Chen
Anthony M. Gamboa
Sarah L. Cristofaro
Steven A. Keilin
Qiang Cai
Field F. Willingham
Publication date: 01-04-2018
Publisher: Springer US
Published in: Journal of Gastrointestinal Surgery / Issue 4/2018
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-017-3500-4

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Incidence, Survival, and Predictors of Lymph Node Involvement in Early-Stage Gastric Signet Ring Cell Carcinoma in the US

Abstract

Introduction

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

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