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01-09-2017 | Original Article

Liver Stiffness Assessed by Shear Wave Elastography Predicts Postoperative Liver Failure in Patients with Hepatocellular Carcinoma

Authors: Yinghao Shen, Chenhao Zhou, Guodong Zhu, Guoming Shi, Xiaodong Zhu, Cheng Huang, Jian Zhou, Jia Fan, Hong Ding, Ning Ren, Hui-Chuan Sun

Published in: Journal of Gastrointestinal Surgery | Issue 9/2017

Abstract

Background

Cirrhosis increases a patient’s risk of developing postoperative liver failure (PLF). Liver stiffness (LS), assessed by two-dimensional shear wave elastography (SWE), indicates liver fibrosis with high accuracy. Whether LS is superior to portal hypertension (PHT) in predicting PLF remains to be studied.

Methods

The study enrolled 280 patients who underwent hepatectomy for hepatocellular carcinoma from July 2015 to July 2016. All patients received preoperative assessments for LS, PHT, and serum markers of liver fibrosis in addition to other clinicopathological tests. Risk factors for grade A and grade B (or greater) PLF were subjected to univariate and multivariate analysis and receiver operating characteristic curve analysis.

Results

Fifty-five patients (19.6%) experienced PLF. The cutoff value of LS for predicting cirrhosis was 10.1 kPa. Multivariate analysis identified LS, hyaluronic acid, IV collagen, and the presence of splenomegaly as independent predictors of PLF. The cutoff value of LS for predicting PLF and grade B (or greater) PLF was 11.75 and 11.9 kPa, respectively. LS was superior to PHT in predicting PLF or greater than grade B PLF (0.72 vs. 0.60, 0.76 vs. 0.59, P < 0.05).

Conclusion

LS measured by SWE can predict risk of PLF with greater accuracy than PHT.

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Title: Liver Stiffness Assessed by Shear Wave Elastography Predicts Postoperative Liver Failure in Patients with Hepatocellular Carcinoma
Authors: Yinghao Shen
Chenhao Zhou
Guodong Zhu
Guoming Shi
Xiaodong Zhu
Cheng Huang
Jian Zhou
Jia Fan
Hong Ding
Ning Ren
Hui-Chuan Sun
Publication date: 01-09-2017
Publisher: Springer US
Published in: Journal of Gastrointestinal Surgery / Issue 9/2017
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-017-3443-9

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Liver Stiffness Assessed by Shear Wave Elastography Predicts Postoperative Liver Failure in Patients with Hepatocellular Carcinoma

Abstract

Background

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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