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Journal of Gastrointestinal Surgery
Published in: Journal of Gastrointestinal Surgery 4/2017

01-04-2017 | Review Article

Predictive Factors for Lymph Node Metastasis in Undifferentiated Early Gastric Cancer: a Systematic Review and Meta-analysis

Authors: Xudong Zhao, Aizhen Cai, Hongqing Xi, Lin Chen, Zheng Peng, Peiyu Li, Na Liu, Jianxin Cui, Hua Li

Published in: Journal of Gastrointestinal Surgery | Issue 4/2017

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Abstract

Objectives

Less invasive surgery is gaining popularity for the treatment of early gastric cancer (EGC), but there are no definitive guidelines for the use of less invasive surgery for the treatment of undifferentiated EGC. The aims of this meta-analysis were to identify potential predictive factors for lymph node metastasis (LNM) in undifferentiated EGC and to guide the personalized therapeutic modality for patients with undifferentiated EGC.

Methods

An extensive search of the PubMed, Embase, and Cochrane Library databases was performed to identify relevant articles involving undifferentiated EGC and LNM. Eligible data were systematically reviewed through a meta-analysis using Review Manager 5.3.

Results

In total, 23 studies were included in this analysis. The meta-analysis found that the variables sex (female), age (greater than 60 years), tumor size (greater than 20 mm), depth of invasion (submucosal invasion), presence of lymphovascular involvement, presence of ulcer findings, histology type (non-signet ring carcinoma), and tumor location (not in the middle part of the stomach) were significantly associated with LNM.

Conclusions

Eight variables were identified as predictive factors for LNM in undifferentiated EGC. The significance of these variables should be further confirmed during the process of LNM in undifferentiated EGC patients for future clinical application.
Appendix
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Metadata
Title
Predictive Factors for Lymph Node Metastasis in Undifferentiated Early Gastric Cancer: a Systematic Review and Meta-analysis
Authors
Xudong Zhao
Aizhen Cai
Hongqing Xi
Lin Chen
Zheng Peng
Peiyu Li
Na Liu
Jianxin Cui
Hua Li
Publication date
01-04-2017
Publisher
Springer US
Published in
Journal of Gastrointestinal Surgery / Issue 4/2017
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI
https://doi.org/10.1007/s11605-017-3364-7

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