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Journal of Gastrointestinal Surgery
Published in: Journal of Gastrointestinal Surgery 4/2017

01-04-2017 | Original Article

Effect of Age (over 75 Years) on Postoperative Complications and Survival in Patients Undergoing Hepatic Resection for Hepatocellular Carcinoma

Authors: Roberto Santambrogio, Matteo Barabino, Giovanna Scifo, Mara Costa, Marco Giovenzana, Enrico Opocher

Published in: Journal of Gastrointestinal Surgery | Issue 4/2017

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Abstract

Background

Thanks to technical advancement in surgery for hepatocellular carcinoma (HCC), hepatic resection (HR) for elderly HCC patients has become safer. However, elderly patients may have shorter long-term survival after surgery if compared with younger patients because of their expected life span. The aim of the present study was to evaluate clinical outcomes and safety after HR in HCC patients aged >75 years (older) compared with HCC patients aged <75 years (younger).

Method

One hundred sixty-eight patients who underwent HR for HCC from 1998 to 2015 in our Center were analyzed using a prospective database. Complications, disease-free survival rates, and cumulative survival rates were compared between the two groups.

Results

During the immediate postoperative period, no differences were found about liver-related complications, hospital stay and 90-day mortality. However, older patients had more complications in class II or higher (Clavien classification) (p = 0.017). Although disease-free survival in both groups was similar (p = 0.099), overall survival was worse in the elderly group (p = 0.024). On multivariate analysis, only age ≥75 years was significantly related to overall survival.

Conclusion

If elderly patients with liver cirrhosis and HCC are appropriately selected and evaluated, they might have favorable prognoses after HR.
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Metadata
Title
Effect of Age (over 75 Years) on Postoperative Complications and Survival in Patients Undergoing Hepatic Resection for Hepatocellular Carcinoma
Authors
Roberto Santambrogio
Matteo Barabino
Giovanna Scifo
Mara Costa
Marco Giovenzana
Enrico Opocher
Publication date
01-04-2017
Publisher
Springer US
Published in
Journal of Gastrointestinal Surgery / Issue 4/2017
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI
https://doi.org/10.1007/s11605-016-3354-1

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