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Journal of Gastrointestinal Surgery
Published in: Journal of Gastrointestinal Surgery 12/2016

01-12-2016 | Original Article

Effect of Resected Gastric Volume on Ghrelin and GLP-1 Plasma Levels: a Prospective Study

Authors: Federico Sista, Valentina Abruzzese, Marco Clementi, Sergio Carandina, Gianfranco Amicucci

Published in: Journal of Gastrointestinal Surgery | Issue 12/2016

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Abstract

Background

The correlation between resected gastric volume (RGV) and neuro-humoral changes (ghrelin and GLP-1) after laparoscopic sleeve gastrectomy (LSG) and their effects on type 2 diabetes mellitus (T2DM) has been evaluated.

Materials

Ninety-eight patients were divided in two groups: RGV <1200 mL (group A: 53 pts) and RGV >1200 mL (group B: 45 pts). Insulin secretion (insulin area under the curve (AUC)), insulinogenic index (IGI) and insulin-resistance (homeostasis model assessment, HOMAIR) were assessed before and after surgery (at the 3rd day and 6, 12 and 24 months after LSG) using the oral glucose tolerance test (OGTT). At the same time, ghrelin and GLP-1 levels were determined.

Results

A significant difference in T2DM resolution rate was observed after 6, 12 and 24 months in favour of RGV >1200 mL. Group B performed better than group A at the 3rd day and at the 6th, 12th and 24th months with regard to AUC, IGI and HOMAIR. In both groups, OGTT resulted in decreased ghrelin values and a significant increase in GLP-1 values for group B at the 3rd day and at the 6th and 12th months with no difference at the 24th month.

Conclusion

Ghrelin and GLP-1 changes play a role in the regulation of glucose metabolism during the 1st year after LSG. RGV influences ghrelin and GLP-1 plasma levels after LSG, with a significant improvement in the T2DM control.
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Metadata
Title
Effect of Resected Gastric Volume on Ghrelin and GLP-1 Plasma Levels: a Prospective Study
Authors
Federico Sista
Valentina Abruzzese
Marco Clementi
Sergio Carandina
Gianfranco Amicucci
Publication date
01-12-2016
Publisher
Springer US
Published in
Journal of Gastrointestinal Surgery / Issue 12/2016
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI
https://doi.org/10.1007/s11605-016-3292-y

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