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01-12-2015 | Original Article

The Neutrophil-to-Lymphocyte Ratio Predicts Malignant Potential in Intraductal Papillary Mucinous Neoplasms

Authors: Kota Arima, Hirohisa Okabe, Daisuke Hashimoto, Akira Chikamoto, Hideyuki Kuroki, Katsunobu Taki, Takayoshi Kaida, Takaaki Higashi, Hidetoshi Nitta, Yoshihiro Komohara, Toru Beppu, Motohiro Takeya, Hideo Baba

Published in: Journal of Gastrointestinal Surgery | Issue 12/2015

Abstract

Background

Accurately identifying malignant components in patients with pancreatic intraductal papillary mucinous neoplasms (IPMN) remains challenging. Preoperative neutrophil-to-lymphocyte ratio (NLR) is a marker of poor prognosis in patients with several types of malignancy. This study assessed whether NLR was predictive of intraductal papillary mucinous carcinoma (IPMC) in patients with IPMN.

Method

This study retrospectively assessed 76 patients who underwent curative resection for IPMN from 1995 to 2015. The correlation between the presence of malignant components and preoperative NLR was analyzed.

Results

Preoperative NLR in IPMC was significantly higher in patients with in IPMC (2.51 ± 0.84) than in patients with intraductal papillary mucinous adenoma (2.01 ± 0.71, P = 0.0079) and healthy volunteers (1.37 ± 0.33, P < 0.0001). NLR was significantly reduced after curative tumor resection. The main duct type (P = 0.0231) and NLR >2.074 (P = 0.0329) were independent predictors of IPMC in all patients. Combined criteria including international consensus guidelines, CA19-9 >37 IU/ml, and NLR >2.074 shows a high positive predictive value of 78 % and high specificity of 96 %.

Conclusions

Preoperative NLR is a useful supportive marker to predict IPMC in patients with IPMN.

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Title: The Neutrophil-to-Lymphocyte Ratio Predicts Malignant Potential in Intraductal Papillary Mucinous Neoplasms
Authors: Kota Arima
Hirohisa Okabe
Daisuke Hashimoto
Akira Chikamoto
Hideyuki Kuroki
Katsunobu Taki
Takayoshi Kaida
Takaaki Higashi
Hidetoshi Nitta
Yoshihiro Komohara
Toru Beppu
Motohiro Takeya
Hideo Baba
Publication date: 01-12-2015
Publisher: Springer US
Published in: Journal of Gastrointestinal Surgery / Issue 12/2015
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-015-2973-2

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

The Neutrophil-to-Lymphocyte Ratio Predicts Malignant Potential in Intraductal Papillary Mucinous Neoplasms

Abstract

Background

Method

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Method

Results

Conclusions

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