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Journal of Gastrointestinal Surgery
Published in: Journal of Gastrointestinal Surgery 11/2015

01-11-2015 | Review Article

Defining Post Hepatectomy Liver Insufficiency: Where do We stand?

Authors: Kelly Lafaro, Stefan Buettner, Hadia Maqsood, Doris Wagner, Fabio Bagante, Gaya Spolverato, Li Xu, Ihab Kamel, Timothy M. Pawlik

Published in: Journal of Gastrointestinal Surgery | Issue 11/2015

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Abstract

Background

Post-hepatectomy liver failure (PHLF) is a major source of morbidity and mortality in patients undergoing liver resection. The aim of this review is to summarize the recent literature available on PHLF including its definition, predictive factors, preoperative risk assessment, severity grading, preventative measures, and management strategies.

Methods

A systematic literature search was carried out with the search engines PubMed, Medline, and Cochrane Database using the keywords related to “liver failure”, “posthepatectomy”, and “hepatic resection”.

Results

Liver resection is a curative treatment of liver tumors. However, it leads to concurrent death and regeneration of the remaining hepatocytes. Factors related to the patient, liver parenchyma and the extent of surgery can inhibit regeneration leading to PHLF.

Conclusion

Given its resistance to treatment and the high postoperative mortality associated with PHLF, great effort has been put in to both accurately identify patients at high risk and to develop strategies that can help prevent its occurrence.
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Metadata
Title
Defining Post Hepatectomy Liver Insufficiency: Where do We stand?
Authors
Kelly Lafaro
Stefan Buettner
Hadia Maqsood
Doris Wagner
Fabio Bagante
Gaya Spolverato
Li Xu
Ihab Kamel
Timothy M. Pawlik
Publication date
01-11-2015
Publisher
Springer US
Published in
Journal of Gastrointestinal Surgery / Issue 11/2015
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI
https://doi.org/10.1007/s11605-015-2872-6

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