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01-07-2015 | Original Article

Lymph Node Harvest During Esophagectomy Is Not Influenced by Use of Neoadjuvant Therapy or Clinical Disease Stage

Authors: Renato A. Luna, James P. Dolan, Brian S. Diggs, Nathan W. Bronson, Brett C. Sheppard, Paul H. Schipper, Brandon H. Tieu, Benjamin T. Feeney, Ken M. Gatter, Gina M. Vaccaro, Charles R. Thomas Jr., John G. Hunter

Published in: Journal of Gastrointestinal Surgery | Issue 7/2015

Abstract

Introduction

The purpose of this study was to evaluate the effects of neoadjuvant therapy on lymph node harvest (LNH), lymph node ratio (LNR), and overall survival rates after esophagectomy.

Methods

A retrospective analysis of 111 patients who underwent esophagectomy for esophageal adenocarcinoma from 2001 to 2010 was performed. Patients were divided into two groups: neoadjuvant chemoradiotherapy prior to surgery (NEOSURG) versus surgery alone (SURG).

Results

There were 83 patients (75 %) in the NEOSURG group and 28 (25 %) in the SURG group with a mean age of 66 and 67 years, respectively. The median LNH in the NEOSURG group and SURG group was 16.0 and 15.5, respectively (p = 0.57). Within the NEOSURG group, the median LNH was 16 for complete responders, 14 for partial responders, 16 for nonresponders, and 18 in those who were pathologically upstaged (p = 0.434). The median LNR was 0, 0, 0.1, and 0.2, respectively (p < 0.001). Complete response after neoadjuvant therapy demonstrated a trend toward improved survival (p = 0.056).

Conclusion

The LNH was not significantly influenced by neoadjuvant treatment or pathologic response. The LNR was inversely related to pathologic response after neoadjuvant therapy. Complete pathologic response to neoadjuvant therapy trends to improve survival rates.

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Title: Lymph Node Harvest During Esophagectomy Is Not Influenced by Use of Neoadjuvant Therapy or Clinical Disease Stage
Authors: Renato A. Luna
James P. Dolan
Brian S. Diggs
Nathan W. Bronson
Brett C. Sheppard
Paul H. Schipper
Brandon H. Tieu
Benjamin T. Feeney
Ken M. Gatter
Gina M. Vaccaro
Charles R. Thomas Jr.
John G. Hunter
Publication date: 01-07-2015
Publisher: Springer US
Published in: Journal of Gastrointestinal Surgery / Issue 7/2015
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-015-2821-4

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Lymph Node Harvest During Esophagectomy Is Not Influenced by Use of Neoadjuvant Therapy or Clinical Disease Stage

Abstract

Introduction

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

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