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01-03-2014 | Original Article

Intranodal Lymphangiogenesis Precedes Development of Lymph Node Metastasis and Accelerates Progression of Gastric Cancer

Authors: Mao Watanabe, Hiroaki Tanaka, Masaichi Ohira, Mami Yoshii, Katsunobu Sakurai, Takahiro Toyokawa, Naoshi Kubo, Atsushi Yamamoto, Kazuya Muguruma, Yoshito Yamashita, Kiyoshi Maeda, Tetsuji Sawada, Kosei Hirakawa

Published in: Journal of Gastrointestinal Surgery | Issue 3/2014

Abstract

Introduction

Peritumoral lymphangiogenesis is significantly correlated with lymph node metastasis and poor prognosis in various cancers. However, there are few reports concerning the role of intranodal lymphangiogenesis in lymphatic metastasis. The aim of this study was to examine the association of lymphangiogenesis in regional lymph nodes with the progression of gastric cancer.

Materials and Methods

Lymphatic vessel density (LVD) was immunohistochemically estimated in 1,596 lymph nodes from 52 patients who underwent gastrectomy.

Results

Intranodal LVD was significantly correlated with the size of metastasis and the progression of cancer. Patients in the high LVD group had significantly poorer prognosis relative to patients in the low LVD group. Furthermore, expression of VEGF-C mRNA was significantly up-regulated in lymph nodes of pathological node positive patients compared to node negative patients.

Discussion

Thus, intranodal lymphangiogenesis was correlated with nodal metastasis and poor prognosis of patients with gastric cancer. Lymphangiogenesis in regional lymph nodes plays an early role in spreading of tumor cells through the lymphatic system to distant organs in gastric cancer.

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Title: Intranodal Lymphangiogenesis Precedes Development of Lymph Node Metastasis and Accelerates Progression of Gastric Cancer
Authors: Mao Watanabe
Hiroaki Tanaka
Masaichi Ohira
Mami Yoshii
Katsunobu Sakurai
Takahiro Toyokawa
Naoshi Kubo
Atsushi Yamamoto
Kazuya Muguruma
Yoshito Yamashita
Kiyoshi Maeda
Tetsuji Sawada
Kosei Hirakawa
Publication date: 01-03-2014
Publisher: Springer US
Published in: Journal of Gastrointestinal Surgery / Issue 3/2014
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-013-2407-y

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Intranodal Lymphangiogenesis Precedes Development of Lymph Node Metastasis and Accelerates Progression of Gastric Cancer

Abstract

Introduction

Materials and Methods

Results

Discussion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Introduction

Materials and Methods

Results

Discussion

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