Skip to main content
Top
Published in: Journal of Gastrointestinal Surgery 2/2014

01-02-2014 | 2013 SSAT Poster Presentation

Endoscopic Ultrasound Staging of Stenotic Esophageal Cancers May Be Unnecessary to Determine the Need for Neoadjuvant Therapy

Authors: Stephanie G. Worrell, Daniel S. Oh, Christina L. Greene, Steven R. DeMeester, Jeffrey A. Hagen

Published in: Journal of Gastrointestinal Surgery | Issue 2/2014

Login to get access

Abstract

Introduction

Endoscopic ultrasound (EUS) is an essential component of preoperative staging for esophageal cancer and is used to determine which patients should proceed to primary surgical resection or receive neoadjuvant therapy prior to surgery. However, when the EUS scope cannot traverse a tumor, the role of pre-dilatation is controversial due to the risk of perforation.

Methods

A retrospective review was conducted of all patients with esophageal tumor stenosis that could not accommodate the EUS scope who then proceeded with primary esophagectomy. The pathology results were classified based on the revised seventh edition American Joint Committee on Cancer staging system.

Results

A total of 27 patients met inclusion criteria. The majority of tumors were T3 (24/27, 89 %). There were no stage I tumors, 15 % (4/27) were stage II, 81 % (22/27) were stage III, and 4 % (1/27) were stage IV due to a resected solitary lung metastasis.

Conclusion

Tumors that cannot be assessed with an EUS scope due to tumor stenosis will have locally advanced disease in the majority of cases. In these situations, pre-dilatation of the tumor with EUS staging should be omitted when considering the risk of potential esophageal perforation and the patients should be referred for neoadjuvant therapy.
Literature
1.
go back to reference Almhanna K, Shridhar R, Meredith KL. Neoadjuvant or adjuvant therapy for resectable esophageal cancer: is there a standard of care? Cancer Control 2013; 20(2):89–96.PubMed Almhanna K, Shridhar R, Meredith KL. Neoadjuvant or adjuvant therapy for resectable esophageal cancer: is there a standard of care? Cancer Control 2013; 20(2):89–96.PubMed
2.
go back to reference Van Hagen P, Hulshof MC, Van Lanschot JJ, Steyerberg EW, van Berge Henegouwen MI, Wijnhoven BP, Richel DJ, Nieuwenhuijzen GA, Hospers GA, Bonenkamp JJ, Cuesta MA, Blaisse RJ, Busch OR, ten Kate FJ, Creemers GJ, Punt CJ, Plukker JT, Verheul HM, Spillenaar Bilgen EJ, van Dekken H, van der Sangen MJ, Rozema T, Biermann K, Beukema JC, Piet AH, van Rij CM, Reinders JG, Tilanus HW, van der Gaast A; CROSS Group. Preoperative chemoradiotherapy for esophageal or junctional cancer. N Engl J Med 2012; 366(22):2074–2084.PubMedCrossRef Van Hagen P, Hulshof MC, Van Lanschot JJ, Steyerberg EW, van Berge Henegouwen MI, Wijnhoven BP, Richel DJ, Nieuwenhuijzen GA, Hospers GA, Bonenkamp JJ, Cuesta MA, Blaisse RJ, Busch OR, ten Kate FJ, Creemers GJ, Punt CJ, Plukker JT, Verheul HM, Spillenaar Bilgen EJ, van Dekken H, van der Sangen MJ, Rozema T, Biermann K, Beukema JC, Piet AH, van Rij CM, Reinders JG, Tilanus HW, van der Gaast A; CROSS Group. Preoperative chemoradiotherapy for esophageal or junctional cancer. N Engl J Med 2012; 366(22):2074–2084.PubMedCrossRef
3.
go back to reference Attila T, Faigel DO. Role of endoscopic ultrasound in superficial esophageal cancer. Dis Esophagus 2009;22:104–12.PubMedCrossRef Attila T, Faigel DO. Role of endoscopic ultrasound in superficial esophageal cancer. Dis Esophagus 2009;22:104–12.PubMedCrossRef
4.
go back to reference Puli SR, Reddy JB, Bechtold ML, Antillon D, Ibdah JA, Antillon MR. Staging accuracy of esophageal cancer by endoscopic ultrasound: a meta-analysis and systematic review. World Journal Gastroenterol 2008; 14(10):1479–1490.CrossRef Puli SR, Reddy JB, Bechtold ML, Antillon D, Ibdah JA, Antillon MR. Staging accuracy of esophageal cancer by endoscopic ultrasound: a meta-analysis and systematic review. World Journal Gastroenterol 2008; 14(10):1479–1490.CrossRef
5.
go back to reference Choi J, Kim SG, Kim JS, Jung HC, Song IS. Comparison of endoscopic ultrasonography (EUS), positron emission tomography (PET), and computed tomography (CT) in the preoperative locoregional staging of resectable esophageal cancer. Surg Endosc 2010; 24:1380–1386.PubMedCrossRef Choi J, Kim SG, Kim JS, Jung HC, Song IS. Comparison of endoscopic ultrasonography (EUS), positron emission tomography (PET), and computed tomography (CT) in the preoperative locoregional staging of resectable esophageal cancer. Surg Endosc 2010; 24:1380–1386.PubMedCrossRef
6.
go back to reference Shimpi RA, George J, Jowell P, Gress FG. Staging of esophageal cancer by EUS: staging accuracy revisited. Gastrointest Endosc 2007; 66(3):475–482.PubMedCrossRef Shimpi RA, George J, Jowell P, Gress FG. Staging of esophageal cancer by EUS: staging accuracy revisited. Gastrointest Endosc 2007; 66(3):475–482.PubMedCrossRef
7.
go back to reference Van Dam J, Rice TW, Catalano MF, Kirby T, Sivak MV Jr. High-grade Malignant Stricture is Predictive of Esophageal Tumor Stage. Risks of Endosonographic Evaluation. Cancer 1993; 71(19):2910–2917.PubMed Van Dam J, Rice TW, Catalano MF, Kirby T, Sivak MV Jr. High-grade Malignant Stricture is Predictive of Esophageal Tumor Stage. Risks of Endosonographic Evaluation. Cancer 1993; 71(19):2910–2917.PubMed
8.
go back to reference Quine MA, Bell GD, McCly RF, Matthews HR. Prospective audit of perforation rates following upper gastrointestinal endoscopy in two regions of England. Br J Surg 1995; 82:530–533.PubMedCrossRef Quine MA, Bell GD, McCly RF, Matthews HR. Prospective audit of perforation rates following upper gastrointestinal endoscopy in two regions of England. Br J Surg 1995; 82:530–533.PubMedCrossRef
9.
go back to reference Jethwa P, Lala P, Powell J, McConkey CC, Gillison EW, Spychal RT. A regional audit of iatrogenic perforations of tumors of the oesophagus and cardia. Aliment Pharmacol Ther 2005; 21(4):479–484.PubMedCrossRef Jethwa P, Lala P, Powell J, McConkey CC, Gillison EW, Spychal RT. A regional audit of iatrogenic perforations of tumors of the oesophagus and cardia. Aliment Pharmacol Ther 2005; 21(4):479–484.PubMedCrossRef
10.
go back to reference Pech O, Gunter E, Dusemund F, Origer J, Lorenz D, Ell C. Accuracy of endoscopic ultrasound in preoperative staging of esophageal cancer: results from a referral center for early esophageal cancer. Endoscopy 2010; 42(6):456–461.PubMedCrossRef Pech O, Gunter E, Dusemund F, Origer J, Lorenz D, Ell C. Accuracy of endoscopic ultrasound in preoperative staging of esophageal cancer: results from a referral center for early esophageal cancer. Endoscopy 2010; 42(6):456–461.PubMedCrossRef
Metadata
Title
Endoscopic Ultrasound Staging of Stenotic Esophageal Cancers May Be Unnecessary to Determine the Need for Neoadjuvant Therapy
Authors
Stephanie G. Worrell
Daniel S. Oh
Christina L. Greene
Steven R. DeMeester
Jeffrey A. Hagen
Publication date
01-02-2014
Publisher
Springer US
Published in
Journal of Gastrointestinal Surgery / Issue 2/2014
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI
https://doi.org/10.1007/s11605-013-2398-8

Other articles of this Issue 2/2014

Journal of Gastrointestinal Surgery 2/2014 Go to the issue