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Journal of Gastrointestinal Surgery

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01-01-2012 | 2011 SSAT Plenary Presentation

Validation of the Updated 7th Edition AJCC TNM Staging Criteria for Gastric Adenocarcinoma

Authors: Lee J. McGhan, Barbara A. Pockaj, Richard J. Gray, Sanjay P. Bagaria, Nabil Wasif

Published in: Journal of Gastrointestinal Surgery | Issue 1/2012

Abstract

Introduction

The recently published 7th edition of the American Joint Committee on Cancer (AJCC) TNM staging criteria for gastric adenocarcinoma contains important revisions to T and N classifications, as well as overall stage grouping. Our goal was to validate the new staging system using a cancer registry.

Methods

Retrospective review of gastric cancer patients from Surveillance, Epidemiology, and End Results (SEER) registry data (2004–2007). Patients were staged according to both 6th and 7th edition criteria, and 3-year disease-specific survival was compared.

Results

Thirteen thousand five hundred forty-seven patients with gastric adenocarcinoma were identified with complete staging information. When using 7th edition criteria, there was an increase in the number of patients classified as stage III (23% vs. 13%), and a decrease in patients classified as stage IV (47% vs. 53%). Statistically significant differences in 3-year disease-specific survival were observed for all T and N categories and re-staging the same population according to the 7th edition criteria improved survival discrimination. Multivariate analysis revealed statistically significant differences in survival and linear progression of hazard ratios for each stage grouping.

Conclusions

The 7th edition AJCC staging criteria for gastric adenocarcinoma demonstrate better survival discrimination and risk stratification than previous criteria.

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Title: Validation of the Updated 7th Edition AJCC TNM Staging Criteria for Gastric Adenocarcinoma
Authors: Lee J. McGhan
Barbara A. Pockaj
Richard J. Gray
Sanjay P. Bagaria
Nabil Wasif
Publication date: 01-01-2012
Publisher: Springer-Verlag
Published in: Journal of Gastrointestinal Surgery / Issue 1/2012
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-011-1707-3

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Validation of the Updated 7th Edition AJCC TNM Staging Criteria for Gastric Adenocarcinoma

Abstract

Introduction

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusions

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