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01-09-2011 | Original Article

Convergence Process of Volumetric Liver Regeneration After Living-Donor Hepatectomy

Authors: Taku Aoki, Hiroshi Imamura, Yutaka Matsuyama, Yoji Kishi, Takashi Kobayashi, Yasuhiko Sugawara, Masatoshi Makuuchi, Norihiro Kokudo

Published in: Journal of Gastrointestinal Surgery | Issue 9/2011

Abstract

Background

We investigated the long-term profiles of liver regeneration after living-donor hepatectomy.

Methods

Thirty-three donors participated in the study. Preoperative and postoperative liver volume was calculated using computed tomography. Volume assessment was repeated at 1 week, 2 weeks, 1 month, 3 months, 6 months, 12 months, and 4 years postoperatively.

Results

Donors were divided into the right (n = 23; residual liver volume, 42%) and left (n = 10; residual liver volume, 63%) groups according to the operative procedures. The restoration ratio to the preoperative liver volume (right vs. left groups) were 51%, 57%, 64%, 74%, 77%, 81%, and 88% vs. 69%, 72%, 76%, 79%, 83%, 84%, and 91% at 1 week, 2 weeks, 1 month, 3 months, 6 months, 12 months, and 4 years, respectively; the interindividual variation in the restoration ratio to the preoperative liver volume became narrower with time.

Conclusion

Liver resection in humans resulted in rapid regeneration during the first 3 months, followed by a more moderate rate of regeneration thereafter, in proportion to the amount of liver mass resected. The volume of the regenerating liver appeared to converge towards the individual preoperative volume with time. However, the liver volume was not restored to the preoperative volume at 4 years after the resection.

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Title: Convergence Process of Volumetric Liver Regeneration After Living-Donor Hepatectomy
Authors: Taku Aoki
Hiroshi Imamura
Yutaka Matsuyama
Yoji Kishi
Takashi Kobayashi
Yasuhiko Sugawara
Masatoshi Makuuchi
Norihiro Kokudo
Publication date: 01-09-2011
Publisher: Springer-Verlag
Published in: Journal of Gastrointestinal Surgery / Issue 9/2011
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-011-1590-y

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Convergence Process of Volumetric Liver Regeneration After Living-Donor Hepatectomy

Abstract

Background

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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