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Journal of Gastrointestinal Surgery

Published in:

01-07-2011 | Original Article

Clinicopathologic Characteristics and Outcomes of Patients with Obstructive Colorectal Cancer

Authors: Zuli Yang, Lei Wang, Liang Kang, Jun Xiang, Junsheng Peng, Ji Cui, Yihua Huang, Jianping Wang

Published in: Journal of Gastrointestinal Surgery | Issue 7/2011

Abstract

Purpose

The aim of this retrospective study was to analyze the clinicopathologic characteristics and short-term and long-term outcomes of colorectal cancer patients with obstruction compared to those of non-obstructive colorectal cancer patients.

Methods

Between January 1998 and December 2005, 1,672 colorectal cancer patients undergoing operation were enrolled in this study. Patients were classified into two groups according to the presentation: patients with complete obstructive colorectal cancer (COC, n = 215) receiving emergency procedures and patients with non-obstructive colorectal cancer (NOC, n = 1,457) receiving elective procedures. The data on the clinicopathologic characteristics and short-term and long-term outcomes of patients were analyzed retrospectively.

Results

Among 1,672 colorectal cancer patients, 215 cases presented with complete obstruction. The distribution of tumor location and size, macroscopic type, depth of invasion, liver metastasis, peritoneal carcinomatosis, and TNM stage were found to be different between the COC and NOC groups. Logistic regression analysis showed that tumor location, depth of invasion, and peritoneal carcinomatosis were independent factors associated with obstruction. Patients with obstruction had an increased risk of death by a factor of 2.251 compared to patients without obstruction. Peritoneal carcinomatosis and TNM stage were independent factors for the survival of the COC group. Obstruction, peritoneal carcinomatosis, tumor macroscopic type, and TNM stage were independent indicators for postoperative recurrence. Postoperative mortality was significantly higher in the COC group than the NOC group. The overall 5- and 10-year survival rates in the COC group were 47.8% and 42.8%, respectively, compared to 67.2% and 59.8% in the NOC group, respectively (p < 0.05). The postoperative recurrence rates were 43.1% in the COC group and 32.8% in the NOC group (p < 0.05).

Conclusions

Obstruction is an independent indicator for the survival and postoperative recurrence for patients with colorectal cancer. Patients in the COC group have worse overall survival with high postoperative recurrence rate compared to those in the NOC group.

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Title: Clinicopathologic Characteristics and Outcomes of Patients with Obstructive Colorectal Cancer
Authors: Zuli Yang
Lei Wang
Liang Kang
Jun Xiang
Junsheng Peng
Ji Cui
Yihua Huang
Jianping Wang
Publication date: 01-07-2011
Publisher: Springer-Verlag
Published in: Journal of Gastrointestinal Surgery / Issue 7/2011
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-011-1563-1

ACC 2024 Congress

Springer Medicine

Clinicopathologic Characteristics and Outcomes of Patients with Obstructive Colorectal Cancer

Abstract

Purpose

Methods

Results

Conclusions

ACC 2024 Congress

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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