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01-04-2011 | Original Article

Anatomic Variations of Intrahepatic Bile Ducts in a European Series and Meta-analysis of the Literature

Authors: Alessandro Cucchetti, Eugenia Peri, Matteo Cescon, Matteo Zanello, Giorgio Ercolani, Chiara Zanfi, Valentina Bertuzzo, Paolo Di Gioia, Antonio Daniele Pinna

Published in: Journal of Gastrointestinal Surgery | Issue 4/2011

Abstract

Background

Accurate knowledge of biliary anatomy and its variants is essential to ensure successful hepatic surgery; however, data from European countries are lacking.

Methods

Two hundred cholangiograms obtained from patients submitted to whole liver transplantation were reviewed; donors’ characteristics were related to the prevalence of typical biliary anatomy and its variants. A comprehensive literature search was performed with MEDLINE and EMBASE from 1980 to 2010 to investigate whether geographical origin could be related to biliary abnormalities.

Results

Typical biliary anatomy was observed in 64.5% of cases, but female donors more frequently presented an anatomic variation; typical anatomy was present in 55.0% of females and in 74.0% of males (P = 0.005). Twenty-two reports were identified by the literature search with a total of 7,559 cases, including the present series; heterogeneity was low (Q = 14.60; I2 < 5.0%) after exclusion of three outlier reports. Prevalence of typical biliary anatomy was similar in Europeans and Americans (∼60%); a slightly higher prevalence was observed in Asiatics (∼65%).

Conclusions

Anatomic variants seem to be more frequent in females, probably as a consequence of different embryologic development. Available data suggest that typical biliary anatomy can be more frequent in Asiatics, but an accurate means of classification is essential to making comparison realistic.

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Title: Anatomic Variations of Intrahepatic Bile Ducts in a European Series and Meta-analysis of the Literature
Authors: Alessandro Cucchetti
Eugenia Peri
Matteo Cescon
Matteo Zanello
Giorgio Ercolani
Chiara Zanfi
Valentina Bertuzzo
Paolo Di Gioia
Antonio Daniele Pinna
Publication date: 01-04-2011
Publisher: Springer-Verlag
Published in: Journal of Gastrointestinal Surgery / Issue 4/2011
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-011-1447-4

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Anatomic Variations of Intrahepatic Bile Ducts in a European Series and Meta-analysis of the Literature

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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