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Journal of Gastrointestinal Surgery

Published in:

01-04-2011 | Review Article

Humans, Mice, and Mechanisms of Intestinal Atresias: A Window into Understanding Early Intestinal Development

Authors: Peter F. Nichol, Amy Reeder, Robert Botham

Published in: Journal of Gastrointestinal Surgery | Issue 4/2011

Abstract

Introduction

Intestinal atresias have long been hypothesized to result from either failure of recanalization of the intestinal lumen or in utero vascular accidents. Recent work in animal models is now calling for a reassessment of these widely held paradigms.

Purpose

In this review, we will examine the data that led to the original hypotheses and then evaluate more recent work challenging these hypotheses. Furthermore, we will discuss how defining the mechanism of atresia formation in animal models may provide insight into early intestinal development and the mechanism of lengthwise intestinal growth.

Conclusion

Such insight will be critical in developing regenerative therapies for patients with intestinal failure.

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Title: Humans, Mice, and Mechanisms of Intestinal Atresias: A Window into Understanding Early Intestinal Development
Authors: Peter F. Nichol
Amy Reeder
Robert Botham
Publication date: 01-04-2011
Publisher: Springer-Verlag
Published in: Journal of Gastrointestinal Surgery / Issue 4/2011
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-010-1400-y

At a glance: The STEP trials

Springer Medicine

Humans, Mice, and Mechanisms of Intestinal Atresias: A Window into Understanding Early Intestinal Development

Abstract

Introduction

Purpose

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Introduction

Purpose

Conclusion

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