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01-02-2011 | Original Article

Radiofrequency Ablation Versus Surgical Resection for Hepatocellular Carcinoma in Childs A Cirrhotics—a Retrospective Study of 1,061 Cases

Authors: Jiwei Huang, Roberto Hernandez-Alejandro, Kristopher P. Croome, Lvnan Yan, Hong Wu, Zheyu Chen, Pankaj Prasoon, Yong Zeng

Published in: Journal of Gastrointestinal Surgery | Issue 2/2011

Abstract

Introduction

The long-term outcomes of radiofrequency ablation (RFA) vs. surgical resection in cirrhotic patients with hepatocellular carcinoma (HCC) remain controversial. One thousand sixty-one cirrhotic HCC patients were included into a retrospective study. Four hundred thirteen received RFA and 648 received surgical resection.

Results

Overall (OS), recurrence-free (RFS), and tumor-free survival (TFS) were compared between the two groups and in subgroup analyses. The 5-year OS and corresponding RFS as well as DFS were significantly higher in the surgical resection group compared with the RFA group (p < 0.001, p < 0.001, p < 0.001). In subgroup analyses of solitary HCC ≤3 cm, there was no significant difference in RFS between the two groups (p = 0.719). Nonetheless, surgical resection was superior to RFA for OS and TFS in this subgroup as well as for OS, RFS, and TFS in subgroup analyses for solitary lesions 3 cm < HCC < 5 cm and multifocal HCC. Serum AFP was the only significant predicting factor for all survival analyses.

Conclusions

When treating Childs A cirrhotic patients with solitary HCC larger than 3 cm but less than 5 cm, or with two or three lesions each less than 5 cm, surgical resection provides a better survival than RFA. When treating Childs A cirrhotics with solitary HCC ≤ 3 cm, RFA has a comparable RFS to surgical resection, but RFA is less invasive.

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Title: Radiofrequency Ablation Versus Surgical Resection for Hepatocellular Carcinoma in Childs A Cirrhotics—a Retrospective Study of 1,061 Cases
Authors: Jiwei Huang
Roberto Hernandez-Alejandro
Kristopher P. Croome
Lvnan Yan
Hong Wu
Zheyu Chen
Pankaj Prasoon
Yong Zeng
Publication date: 01-02-2011
Publisher: Springer-Verlag
Published in: Journal of Gastrointestinal Surgery / Issue 2/2011
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-010-1372-y

At a glance: The STEP trials

Springer Medicine

Radiofrequency Ablation Versus Surgical Resection for Hepatocellular Carcinoma in Childs A Cirrhotics—a Retrospective Study of 1,061 Cases

Abstract

Introduction

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Introduction

Results

Conclusions

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