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01-09-2009 | Original Article

Prognostic Factors in Patients with Synchronous Peritoneal Carcinomatosis (PC) Caused by a Primary Cancer of the Colon

Authors: Sotaro Sadahiro, Toshiyuki Suzuki, Yuji Maeda, Akira Tanaka, Hiroyasu Makuuchi, Akemi Kamijo, Yasuo Haruki, Chieko Murayama

Published in: Journal of Gastrointestinal Surgery | Issue 9/2009

Abstract

Background

Peritoneal carcinomatosis (PC) is seen in about 10% of patients with colon cancer during the initial operation and has been considered a preterminal condition. The actual outcome can vary extensively depending on the presence/absence of metastases other than PC.

Methods

A total of 975 consecutive patients with colon cancer who underwent resection were included. The extent of PC was determined at laparotomy. Metastases restricted to the adjacent peritoneum or a few metastases to the distant peritoneum were classified as “limited,” whereas numerous metastases to the distant peritoneum were as “extensive” regardless of the sizes of the disseminated nodules.

Results

PC group consisted of 75 patients (7.7%). The median survival time (MST) in the PC group was 6.8 months. Survival was significantly better in cases with limited PC (MST, 12.4 months), without lymph node involvement (20.8 months), with preoperative performance status of 0 or 1 (8.5 months), and who received chemotherapy more than 3 months (8.8 months). A multivariate analysis revealed that these four factors were significant predictors of better outcome.

Conclusions

The extent of PC and lymph node involvement, even if the distribution is confined around the primary lesion, are more accurate prognostic factors than distant metastasis in patients with colon cancer and synchronous PC.

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Title: Prognostic Factors in Patients with Synchronous Peritoneal Carcinomatosis (PC) Caused by a Primary Cancer of the Colon
Authors: Sotaro Sadahiro
Toshiyuki Suzuki
Yuji Maeda
Akira Tanaka
Hiroyasu Makuuchi
Akemi Kamijo
Yasuo Haruki
Chieko Murayama
Publication date: 01-09-2009
Publisher: Springer-Verlag
Published in: Journal of Gastrointestinal Surgery / Issue 9/2009
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-009-0939-y

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Prognostic Factors in Patients with Synchronous Peritoneal Carcinomatosis (PC) Caused by a Primary Cancer of the Colon

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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