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01-04-2009 | original article

A Critical Analysis of the Surgical Management of Early-Stage Gallbladder Cancer in the United States

Authors: Eric H. Jensen, Anasooya Abraham, Elizabeth B. Habermann, Waddah B. Al-Refaie, Selwyn M. Vickers, Beth A. Virnig, Todd M. Tuttle

Published in: Journal of Gastrointestinal Surgery | Issue 4/2009

Abstract

Background

Radical resection is recommended for selected patients with gallbladder (GB) cancer. We sought to determine whether radical resection improves survival for patients with early-stage cancer and to evaluate surgeon compliance with current treatment recommendations.

Patients and methods

Patients with stage 0, I, or II GB cancer who underwent surgical resection were identified from the Surveillance, Epidemiology, and End Results (SEER) tumor registry from 1988 through 2004. Patients were classified by surgical procedure performed (simple vs. radical resection) and adjuvant treatment given (radiation therapy [RT] vs. no RT). Unadjusted and adjusted overall survival (OS) and cancer-specific survival (CSS) were compared.

Results

Of the 4,631 patients who underwent surgery for early-stage GB cancer from 1988 through 2004, 4,188 (90.4%) underwent cholecystectomy alone and 443 (9.6%) underwent radical surgery including hepatic resection. The proportion of patients having radical surgery for T1b, T2, and T3 cancers was 4.5%, 5.6%, and 16.3%, respectively. For patients with T1b/T2 cancer, radical resection was associated with significant improvement in adjusted CSS (p = 0.01) and OS (p = 0.03). For patients with T3 cancers, we noted no improvement in CSS or OS. Survival for patients with node-positive disease (stage 2b) was universally poor and not improved by radical resection. For all patients who underwent radical resection, node negativity, female sex, age <70, low grade, and RT predicted improved CSS and OS.

Conclusions

Despite a significant survival advantage for patients with T1b/T2 GB cancer who undergo radical resection, this treatment is significantly underutilized. Ensuring delivery of recommended surgical treatment is vital to improving outcomes for patients with this disease.

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Title: A Critical Analysis of the Surgical Management of Early-Stage Gallbladder Cancer in the United States
Authors: Eric H. Jensen
Anasooya Abraham
Elizabeth B. Habermann
Waddah B. Al-Refaie
Selwyn M. Vickers
Beth A. Virnig
Todd M. Tuttle
Publication date: 01-04-2009
Publisher: Springer-Verlag
Published in: Journal of Gastrointestinal Surgery / Issue 4/2009
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-008-0772-8

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

A Critical Analysis of the Surgical Management of Early-Stage Gallbladder Cancer in the United States

Abstract

Background

Patients and methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Patients and methods

Results

Conclusions

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