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01-11-2008 | ssat poster presentation

Hepatic Neuroendocrine Metastases: Chemo- or Bland Embolization?

Authors: Susan C. Pitt, Jaime Knuth, James M. Keily, John C. McDermott, Sharon M. Weber, Hebert Chen, William S. Rilling, Edward J. Quebbeman, David M. Agarwal, Henry A. Pitt

Published in: Journal of Gastrointestinal Surgery | Issue 11/2008

Abstract

Introduction

Aggressive management of hepatic neuroendocrine (NE) metastases improves symptoms and prolongs survival. Because of the rarity of these tumors, however, the best method for hepatic artery embolization has not been established. We hypothesized that in patients with hepatic NE metastases, hepatic artery chemoembolization (HACE) would result in better symptom improvement and survival compared to bland embolization (HAE).

Methods

Retrospective review identified all patients with NE hepatic metastases managed by HACE or HAE at three institutions from January 1996 through December 2007.

Results

We identified 100 patients managed by HACE (n = 49) or HAE (n = 51) that were similar with respect to age, gender, and primary tumor type. The percentage of patients experiencing morbidity, 30-day mortality, and symptom improvement were similar between the two groups (HACE vs. HAE: 2.4% vs. 6.6%; 0.8% vs. 1.8%; and 88% vs. 83%, respectively.) No differences in the median overall survival were observed between HACE and HAE from the time of the first embolization procedure (25.5 vs. 25.7 months, p = 0.79). Multivariate analysis revealed that resection of the primary tumor predicted survival (73.8 vs. 19.4 months, p < 0.04).

Conclusions

These data suggest that morbidity, mortality, symptom improvement, and overall survival are similar in patients with hepatic neuroendocrine metastases managed by chemo- or bland hepatic artery embolization.

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Title: Hepatic Neuroendocrine Metastases: Chemo- or Bland Embolization?
Authors: Susan C. Pitt
Jaime Knuth
James M. Keily
John C. McDermott
Sharon M. Weber
Hebert Chen
William S. Rilling
Edward J. Quebbeman
David M. Agarwal
Henry A. Pitt
Publication date: 01-11-2008
Publisher: Springer-Verlag
Published in: Journal of Gastrointestinal Surgery / Issue 11/2008
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-008-0640-6

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Hepatic Neuroendocrine Metastases: Chemo- or Bland Embolization?

Abstract

Introduction

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusions

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