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01-11-2008 | ssat poster presentation

The Integrity of Esophagogastric Junction Anatomy in Patients with Isolated Laryngopharyngeal Reflux Symptoms

Authors: Kyle A. Perry, C. Kristian Enestvedt, Cedric S. F. Lorenzo, Paul Schipper, Joshua Schindler, Cynthia D. Morris, Katie Nason, James D. Luketich, John G. Hunter, Blair A. Jobe

Published in: Journal of Gastrointestinal Surgery | Issue 11/2008

Abstract

Background

Distortion of esophagogastric junction anatomy in patients with gastroesophageal reflux disease produces permanent dilation of the gastric cardia proportional to disease severity, but it remains unclear whether this mechanism underlies reflux in patients with isolated laryngopharyngeal reflux symptoms.

Method

In a prospective study, 113 patients were stratified into three populations based on symptom complex: laryngopharyngeal reflux symptoms, typical reflux symptoms, and both laryngopharyngeal and typical symptoms. Subjects underwent small-caliber upper endoscopy in the upright position. Outcome measures included gastric cardia circumference, presence and size of hiatal hernia, and prevalence of esophagitis and Barrett’s esophagus within each group.

Results

There were no differences in gastric cardia circumference between patient groups. The prevalence of Barrett’s esophagus was 20.4% overall and 15.6% in pure laryngopharyngeal reflux patients. Barrett’s esophagus patients had a greater cardia circumference compared to those without it. In the upright position, patients with isolated laryngopharyngeal reflux display the same degree of esophagogastric junction distortion as those with typical reflux symptoms, suggesting a similar pathophysiology.

Conclusion

This indicates that, although these patients may sense reflux differently, they have similar risks as patients with typical symptoms. Further, the identification of Barrett’s esophagus in the absence of typical reflux symptoms suggests the potential for occult disease progression and late discovery of cancer.

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Title: The Integrity of Esophagogastric Junction Anatomy in Patients with Isolated Laryngopharyngeal Reflux Symptoms
Authors: Kyle A. Perry
C. Kristian Enestvedt
Cedric S. F. Lorenzo
Paul Schipper
Joshua Schindler
Cynthia D. Morris
Katie Nason
James D. Luketich
John G. Hunter
Blair A. Jobe
Publication date: 01-11-2008
Publisher: Springer-Verlag
Published in: Journal of Gastrointestinal Surgery / Issue 11/2008
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-008-0607-7

At a glance: The STEP trials

Springer Medicine

The Integrity of Esophagogastric Junction Anatomy in Patients with Isolated Laryngopharyngeal Reflux Symptoms

Abstract

Background

Method

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Method

Results

Conclusion

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