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01-08-2008 | original article

Salvage Gastrectomy Following a Combination of Biweekly Paclitaxel and S-1 for Stage IV Gastric Cancer

Authors: Sumiya Ishigami, Shoji Natsugoe, Akihiro Nakajo, Masataka Matsumoto, Yoshikazu Uenosono, Takaaki Arigami, Tetsuro Setoyama, Hideo Arima, Yasuto Uchikado, Yoshiaki Kita, Ken Sasaki, Takashi Aikou

Published in: Journal of Gastrointestinal Surgery | Issue 8/2008

Abstract

Background and aim

We investigated the clinical benefits of salvage gastrectomy for stage IV gastric cancer patients whose distant lesions showed complete response after chemotherapy.

Methods

We enrolled 18 stage IV gastric cancer patients whose distant metastases had disappeared or were controlled by a combination of biweekly paclitaxel (PTX) and S-1. After chemotherapy, these patients received gastrectomy with lymph node dissection. The postoperative outcome was analyzed with respect to both the histological effects of chemotherapy and tumor behavior.

Results

Of the 18 patients, 8 had distant lymph node metastases, 9 had peritoneal dissemination, and five had multiple liver metastases prior to chemotherapy. Fourteen patients received curative surgery (R0). No severe postoperative complications were encountered. Pathological evaluation revealed grade 3 and grade 2 tumor regression in the primary lesion in one and five patients, respectively, and grade 3 and grade 2 tumor regression in the lymph nodes in one and six patients, respectively. Univariate analysis of the patients’ prognosis identified R number, gross tumor type, histological grade of tumor regression, and gender as significant factors. Multivariate analysis showed that only the R number was an independent prognostic factor.

Conclusion

R0 salvage gastrectomy following a combination of biweekly PTX and S-1 may have significant clinical efficacy for advanced gastric cancer patients.

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Title: Salvage Gastrectomy Following a Combination of Biweekly Paclitaxel and S-1 for Stage IV Gastric Cancer
Authors: Sumiya Ishigami
Shoji Natsugoe
Akihiro Nakajo
Masataka Matsumoto
Yoshikazu Uenosono
Takaaki Arigami
Tetsuro Setoyama
Hideo Arima
Yasuto Uchikado
Yoshiaki Kita
Ken Sasaki
Takashi Aikou
Publication date: 01-08-2008
Publisher: Springer-Verlag
Published in: Journal of Gastrointestinal Surgery / Issue 8/2008
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-008-0539-2

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Salvage Gastrectomy Following a Combination of Biweekly Paclitaxel and S-1 for Stage IV Gastric Cancer

Abstract

Background and aim

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background and aim

Methods

Results

Conclusion

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