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Published in: Journal of Gastrointestinal Surgery 3/2008

01-03-2008 | original article

Use of Antireflux Medication After Antireflux Surgery

Authors: Bas P. L. Wijnhoven, Carolyn J. Lally, John J. Kelly, Jennifer C. Myers, David I. Watson

Published in: Journal of Gastrointestinal Surgery | Issue 3/2008

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Abstract

Introduction

It is claimed that a substantial number of patients who undergo antireflux surgery use antireflux medication postoperatively. This study was aimed to determine the prevalence and underlying reasons for antireflux medication usage in patients after surgery.

Materials and Methods

A questionnaire on the usage of antireflux medication was sent to 1,008 patients identified from a prospective database of patients who had undergone a laparoscopic antireflux procedure.

Results

A total of 844 patients (84%) returned the questionnaire. Mean follow-up was 5.9 years after surgery. A single or combination of medications was being taken by 312 patients (37%): 82% proton pump inhibitors, 9% H2-blockers and 34% antacids. Fifty-two patients (17%) had never stopped taking medication, whereas 260 patients (83%) restarted medication at a mean of 2.5 years after surgery. Return of the same (31%) or different (49%) symptoms were the commonest reasons for taking medication, whereas 20% were asymptomatic or had other reasons for medication use. Postoperative 24-hour pH studies were abnormal in 16/61 patients (26%) on medication and in 5/78 patients (6%) not taking medication.

Conclusions

Antireflux medication is frequently taken by many patients for various symptoms after antireflux surgery. Symptomatic patients should be properly investigated before antireflux medications are prescribed.
Literature
1.
go back to reference Watson DI, Jamieson GG, Devitt PG, Kennedy JA, Ellis T, Ackroyd R, Lafullarde T, Game PA. A prospective randomized trial of laparoscopic Nissen fundoplication with anterior vs posterior hiatal repair. Arch Surg 2001;136:745–751.PubMedCrossRef Watson DI, Jamieson GG, Devitt PG, Kennedy JA, Ellis T, Ackroyd R, Lafullarde T, Game PA. A prospective randomized trial of laparoscopic Nissen fundoplication with anterior vs posterior hiatal repair. Arch Surg 2001;136:745–751.PubMedCrossRef
2.
go back to reference Bammer T, Hinder RA, Klaus A, Klingler PJ. Five- to eight-year outcome of the first laparoscopic Nissen fundoplications. J Gastrointest Surg 2001;5:42–48.PubMedCrossRef Bammer T, Hinder RA, Klaus A, Klingler PJ. Five- to eight-year outcome of the first laparoscopic Nissen fundoplications. J Gastrointest Surg 2001;5:42–48.PubMedCrossRef
3.
go back to reference Vakil N, Shaw M, Kirby R. Clinical effectiveness of laparoscopic fundoplication in a U.S. community. Am J Med 2003;114:1–5.PubMedCrossRef Vakil N, Shaw M, Kirby R. Clinical effectiveness of laparoscopic fundoplication in a U.S. community. Am J Med 2003;114:1–5.PubMedCrossRef
4.
go back to reference Bonatti H, Bammer T, Achem SR, Lukens F, Devault KR, Klaus A, Hinder RA. Use of Acid suppressive medications after laparoscopic antireflux surgery: prevalence and clinical indications. Dig Dis Sci 2007;52:267–272.PubMedCrossRef Bonatti H, Bammer T, Achem SR, Lukens F, Devault KR, Klaus A, Hinder RA. Use of Acid suppressive medications after laparoscopic antireflux surgery: prevalence and clinical indications. Dig Dis Sci 2007;52:267–272.PubMedCrossRef
5.
go back to reference Bloomston M, Nields W, Rosemurgy AS. Symptoms and antireflux medication use following laparoscopic Nissen fundoplication: Outcome at 1 and 4 years. J Soc Laparoendosc Surg 2003;7:211–218. Bloomston M, Nields W, Rosemurgy AS. Symptoms and antireflux medication use following laparoscopic Nissen fundoplication: Outcome at 1 and 4 years. J Soc Laparoendosc Surg 2003;7:211–218.
6.
go back to reference Rice S, Watson DI, Lally CJ, Devitt PG, Game PA, Jamieson GG. Laparoscopic anterior 180 degrees partial fundoplication: five-year results and beyond. Arch Surg 2006;141:271–275.PubMedCrossRef Rice S, Watson DI, Lally CJ, Devitt PG, Game PA, Jamieson GG. Laparoscopic anterior 180 degrees partial fundoplication: five-year results and beyond. Arch Surg 2006;141:271–275.PubMedCrossRef
7.
go back to reference Papasavas PK, Keenan RJ, Yeaney WW, Caushaj PF, Gagne DJ, Landreneau RJ. Effectiveness of laparoscopic fundoplication in relieving the symptoms of gastroesophageal reflux disease (GERD) and eliminating antireflux medical therapy. Surg Endosc 2003;17:1200–1205.PubMedCrossRef Papasavas PK, Keenan RJ, Yeaney WW, Caushaj PF, Gagne DJ, Landreneau RJ. Effectiveness of laparoscopic fundoplication in relieving the symptoms of gastroesophageal reflux disease (GERD) and eliminating antireflux medical therapy. Surg Endosc 2003;17:1200–1205.PubMedCrossRef
8.
go back to reference Lundell L, Miettinen P, Myrvold HE, Pedersen SA, Liedman B, Hatlebakk JG, Julkonen R, Levander K, Carlsson J, Lamm M, Wiklund I. Continued (5-year) follow-up of a randomized clinical study comparing antireflux surgery and omeprazole in gastroesophageal reflux disease. J Am Coll Surg 2001;192:172–179; discussion 179–181.PubMedCrossRef Lundell L, Miettinen P, Myrvold HE, Pedersen SA, Liedman B, Hatlebakk JG, Julkonen R, Levander K, Carlsson J, Lamm M, Wiklund I. Continued (5-year) follow-up of a randomized clinical study comparing antireflux surgery and omeprazole in gastroesophageal reflux disease. J Am Coll Surg 2001;192:172–179; discussion 179–181.PubMedCrossRef
9.
go back to reference Lafullarde T, Watson DI, Jamieson GG, Myers JC, Game PA, Devitt PG. Laparoscopic Nissen fundoplication: Five-year results and beyond. Arch Surg 2001;136:180–184.PubMedCrossRef Lafullarde T, Watson DI, Jamieson GG, Myers JC, Game PA, Devitt PG. Laparoscopic Nissen fundoplication: Five-year results and beyond. Arch Surg 2001;136:180–184.PubMedCrossRef
10.
go back to reference Draaisma WA, Rijnhart-de Jong HG, Broeders IA, Smout AJ, Furnee EJ, Gooszen HG. Five-year subjective and objective results of laparoscopic and conventional Nissen fundoplication: a randomized trial. Ann Surg 2006;244:34–41.PubMedCrossRef Draaisma WA, Rijnhart-de Jong HG, Broeders IA, Smout AJ, Furnee EJ, Gooszen HG. Five-year subjective and objective results of laparoscopic and conventional Nissen fundoplication: a randomized trial. Ann Surg 2006;244:34–41.PubMedCrossRef
11.
go back to reference Lord RV, Kaminski A, Oberg S, Bowrey DJ, Hagen JA, DeMeester SR, Sillin LF, Peters JH, Crookes PF, DeMeester TR. Absence of gastroesophageal reflux disease in a majority of patients taking acid suppression medications after Nissen fundoplication. J Gastrointest Surg 2002;6:3–9; discussion 10.PubMedCrossRef Lord RV, Kaminski A, Oberg S, Bowrey DJ, Hagen JA, DeMeester SR, Sillin LF, Peters JH, Crookes PF, DeMeester TR. Absence of gastroesophageal reflux disease in a majority of patients taking acid suppression medications after Nissen fundoplication. J Gastrointest Surg 2002;6:3–9; discussion 10.PubMedCrossRef
12.
go back to reference Galvani C, Fisichella PM, Gorodner MV, Perretta S, Patti MG. Symptoms are a poor indicator of reflux status after fundoplication for gastroesophageal reflux disease: role of esophageal functions tests. Arch Surg 2003;138:514–518; discussion 518–519.PubMedCrossRef Galvani C, Fisichella PM, Gorodner MV, Perretta S, Patti MG. Symptoms are a poor indicator of reflux status after fundoplication for gastroesophageal reflux disease: role of esophageal functions tests. Arch Surg 2003;138:514–518; discussion 518–519.PubMedCrossRef
13.
go back to reference Jamieson GG, Watson DI, Britten-Jones R, Mitchell PC, Anvari M. Laparoscopic Nissen fundoplication. Ann Surg 1994;220:137–145.PubMedCrossRef Jamieson GG, Watson DI, Britten-Jones R, Mitchell PC, Anvari M. Laparoscopic Nissen fundoplication. Ann Surg 1994;220:137–145.PubMedCrossRef
14.
go back to reference Krysztopik RJ, Jamieson GG, Devitt PG, Watson DI. A further modification of fundoplication. 90 degrees anterior fundoplication. Surg Endosc 2002;16:1446–1451.PubMedCrossRef Krysztopik RJ, Jamieson GG, Devitt PG, Watson DI. A further modification of fundoplication. 90 degrees anterior fundoplication. Surg Endosc 2002;16:1446–1451.PubMedCrossRef
15.
go back to reference Watson DI, Liu JF, Devitt PG, Game PA, Jamieson GG. Outcome of laparoscopic anterior 180-degree partial fundoplication for gastroesophageal reflux disease. J Gastrointest Surg 2000;4:486–492.PubMedCrossRef Watson DI, Liu JF, Devitt PG, Game PA, Jamieson GG. Outcome of laparoscopic anterior 180-degree partial fundoplication for gastroesophageal reflux disease. J Gastrointest Surg 2000;4:486–492.PubMedCrossRef
16.
go back to reference Australian Government DoHaA. Schedule of Pharmaceutical Benefits for Approved Pharmacists and Medical Practitioners. Australia: Australian Government, Department of Health and Ageing, 2006. Australian Government DoHaA. Schedule of Pharmaceutical Benefits for Approved Pharmacists and Medical Practitioners. Australia: Australian Government, Department of Health and Ageing, 2006.
17.
go back to reference Khaitan L, Ray WA, Holzman MD, Smalley WE. Health care utilization after medical and surgical therapy for gastroesophageal reflux disease: A population-based study, 1996 to 2000. Arch Surg 2003;138:1356–1361.PubMedCrossRef Khaitan L, Ray WA, Holzman MD, Smalley WE. Health care utilization after medical and surgical therapy for gastroesophageal reflux disease: A population-based study, 1996 to 2000. Arch Surg 2003;138:1356–1361.PubMedCrossRef
18.
go back to reference Dominitz JA, Dire CA, Billingsley KG, Todd-Stenberg JA. Complications and antireflux medication use after antireflux surgery. Clin Gastroenterol Hepatol 2006;4:299–305.PubMedCrossRef Dominitz JA, Dire CA, Billingsley KG, Todd-Stenberg JA. Complications and antireflux medication use after antireflux surgery. Clin Gastroenterol Hepatol 2006;4:299–305.PubMedCrossRef
19.
go back to reference O’Boyle CJ, Watson DI, DeBeaux AC, Jamieson GG. Preoperative prediction of long-term outcome following laparoscopic fundoplication. Aust NZ J Surg 2002;72:471–475.CrossRef O’Boyle CJ, Watson DI, DeBeaux AC, Jamieson GG. Preoperative prediction of long-term outcome following laparoscopic fundoplication. Aust NZ J Surg 2002;72:471–475.CrossRef
20.
go back to reference Jenkinson AD, Kadirkamanathan SS, Scott SM, Yazaki E, Evans DF. Relationship between symptom response and oesophageal acid exposure after medical and surgical treatment for gastro-oesophageal reflux disease. Br J Surg 2004;91:1460–1465.PubMedCrossRef Jenkinson AD, Kadirkamanathan SS, Scott SM, Yazaki E, Evans DF. Relationship between symptom response and oesophageal acid exposure after medical and surgical treatment for gastro-oesophageal reflux disease. Br J Surg 2004;91:1460–1465.PubMedCrossRef
21.
go back to reference Khajanchee YS, O’Rourke RW, Lockhart B, Patterson EJ, Hansen PD, Swanstrom LL. Postoperative symptoms and failure after antireflux surgery. Arch Surg 2002;137:1008–1013; discussion 1013–1004.PubMedCrossRef Khajanchee YS, O’Rourke RW, Lockhart B, Patterson EJ, Hansen PD, Swanstrom LL. Postoperative symptoms and failure after antireflux surgery. Arch Surg 2002;137:1008–1013; discussion 1013–1004.PubMedCrossRef
22.
go back to reference Velanovich V. Nonsurgical factors affecting symptomatic outcomes of antireflux surgery. Dis Esophagus 2006;19:1–4.PubMedCrossRef Velanovich V. Nonsurgical factors affecting symptomatic outcomes of antireflux surgery. Dis Esophagus 2006;19:1–4.PubMedCrossRef
23.
go back to reference Scheffer RC, Gooszen HG, Wassenaar EB, Samsom M. Relationship between partial gastric volumes and dyspeptic symptoms in fundoplication patients: A 3D ultrasonographic study. Am J Gastroenterol 2004;99:1902–1909.PubMedCrossRef Scheffer RC, Gooszen HG, Wassenaar EB, Samsom M. Relationship between partial gastric volumes and dyspeptic symptoms in fundoplication patients: A 3D ultrasonographic study. Am J Gastroenterol 2004;99:1902–1909.PubMedCrossRef
24.
go back to reference Scheffer RC, Samsom M, Frakking TG, Smout AJ, Gooszen HG. Long-term effect of fundoplication on motility of the oesophagus and oesophagogastric junction. Br J Surg 2004;91:1466–1472.PubMedCrossRef Scheffer RC, Samsom M, Frakking TG, Smout AJ, Gooszen HG. Long-term effect of fundoplication on motility of the oesophagus and oesophagogastric junction. Br J Surg 2004;91:1466–1472.PubMedCrossRef
25.
go back to reference Wijnhoven BP, Salet GA, Roelofs JM, Smout AJ, Akkermans LM, Gooszen HG. Function of the proximal stomach after Nissen fundoplication. Br J Surg 1998;85:267–271.PubMedCrossRef Wijnhoven BP, Salet GA, Roelofs JM, Smout AJ, Akkermans LM, Gooszen HG. Function of the proximal stomach after Nissen fundoplication. Br J Surg 1998;85:267–271.PubMedCrossRef
26.
go back to reference Guillemot F, Ducrotte P, Bueno L. Prevalence of functional gastrointestinal disorders in a population of subjects consulting for gastroesophageal reflux disease in general practice. Gastroenterol Clin Biol 2005;29:243–246.PubMedCrossRef Guillemot F, Ducrotte P, Bueno L. Prevalence of functional gastrointestinal disorders in a population of subjects consulting for gastroesophageal reflux disease in general practice. Gastroenterol Clin Biol 2005;29:243–246.PubMedCrossRef
27.
go back to reference Spechler SJ, Lee E, Ahnen D, Goyal RK, Hirano I, Ramirez F, Raufman JP, Sampliner R, Schnell T, Sontag S, Vlahcevic ZR, Young R, Williford W. Long-term outcome of medical and surgical therapies for gastroesophageal reflux disease: Follow-up of a randomized controlled trial. JAMA 2001;285:2331–2338.PubMedCrossRef Spechler SJ, Lee E, Ahnen D, Goyal RK, Hirano I, Ramirez F, Raufman JP, Sampliner R, Schnell T, Sontag S, Vlahcevic ZR, Young R, Williford W. Long-term outcome of medical and surgical therapies for gastroesophageal reflux disease: Follow-up of a randomized controlled trial. JAMA 2001;285:2331–2338.PubMedCrossRef
Metadata
Title
Use of Antireflux Medication After Antireflux Surgery
Authors
Bas P. L. Wijnhoven
Carolyn J. Lally
John J. Kelly
Jennifer C. Myers
David I. Watson
Publication date
01-03-2008
Publisher
Springer-Verlag
Published in
Journal of Gastrointestinal Surgery / Issue 3/2008
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI
https://doi.org/10.1007/s11605-007-0443-1

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