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01-03-2008 | SSAT other

Mucinous Cystic Neoplasms

Author: Carlos Fernández-del Castillo

Published in: Journal of Gastrointestinal Surgery | Issue 3/2008

Abstract

Mucinous cystic neoplasms of the pancreas are uncommon tumors of the pancreas that occur predominantly in middle-aged women and almost exclusively in the body and tail of the pancreas. They are lined by a mucinous epithelium that can exhibit varying grades of dysplasia and are surrounded by a characteristic ovarian-like stroma. Surgery is the treatment of choice, and prognosis is excellent in the absence of invasive carcinoma.

Compagno J, Oertel JE. Mucinous cystic neoplasms of the pancreas with overt and latent malignancy (cystadenocarcinoma and cystadenoma). A clinicopathologic study of 41 cases. Am J Clin Pathol 1978;69:573–580.PubMed

Compagno J, Oertel JE. Microcystic adenomas of the pancreas (glycogen-rich cystadenomas): a clinicopathologic study of 34 cases. Am J Clin Pathol 1978;69:289–298.PubMed

Wilentz RE, Albores-Saavedra J, Zahurak M, Talamini MA, Yeo CJ, Cameron JL, Hruban RH. Pathologic examination accurately predicts prognosis in mucinous cystic neoplasms of the pancreas. Am J Surg Pathol 1999;23:1320–1327.PubMedCrossRef

Warshaw AL, Compton CC, Lewandrowski K, Cardenosa G, Mueller PR. Cystic tumors of the pancreas. New clinical, radiologic, and pathologic observations in 67 patients. Ann Surg 1990;212:432–443.PubMedCrossRef

Le Borgne J, de Calan L, Partensky C, the French Surgical Association. Cystadenomas and cystadenocarcinomas of the pancreas. A multiinstitutional retrospective study of 398 cases. Ann Surg 1999;230;152–161.PubMedCrossRef

Sarr MG, Carpenter HA, Prabhakar LP, Orchard TF, Hughes S, van Heerden JA, DiMagno EP. Clinical and pathologic correlation of 84 mucinous cystic neoplasms of the pancreas. Can one reliably differentiate benign from malignant (or premalignant) neoplasms? Ann Surg 2000;231:205–212.PubMedCrossRef

Kloppel G, Solcia E, Longnecker DS, Capella C, Sobin LH. Histological typing of tumors of the exocrine pancreas. In: World Health Organization, ed. International Histological Classification of Tumors. Berlin Heidelberg New York: Springer, 1996.

Tanaka M, Chari S, Adsay V, Fernandez-del Castillo C, Falconi M, Shimizu M, Yamaguchi K, Yamao K, Matsuno S; International Association of Pancreatology. International consensus guidelines for management of intraductal papillary mucinous neoplasms and mucinous cystic neoplasms of the pancreas. Pancreatology 2006;6:17–32.PubMedCrossRef

Crippa S, Salvia R, Warshaw AL, Dominguez I, Bassi C, Falconi M, Thayer SP, Zamboni G, Lauwers GY, Mino-Kenudson M, Capelli P, Pederzoli P, Fernandez-del Castillo. Mucinous cystic neoplasm of the pancreas is not an aggressive entity. Lessons from 163 resected patients. Ann Surg 2007; in press.

10.

Zamboni G, Scarpa A, Bogina G, Iacono C, Bassi C, Talamini G, Sessa F, Capella C, Solcia E, Rickaert F, Mariuzzi GM, Kloppel G. Mucinous cystic tumors of the pancreas: clinicopathological features, prognosis, and relationship to other mucinous cystic tumors. Am J Surg Pathol 1999;23:410–422.PubMedCrossRef

11.

Thompson LD, Becker RC, Przygodzki RM, Adair CF, Heffess CS. Mucinous cystic neoplasm (mucinous cystadenocarcinoma of low-grade malignant potential) of the pancreas: a clinicopathologic study of 130 cases. Am J Surg Pathol 1999;23:1–16.PubMedCrossRef

12.

Reddy RP, Smyrk TC, Zapiach M, Levi MJ, Pearson RK, Clain JE, Farnell MB, Sarr MG, Chari ST. Pancreatic mucinous cystic neoplasm defined by ovarian stroma: demographics, clinical features, and prevalence of cancer. Clin Gastroenterol Hepatol 2004;2:1026–1031.PubMedCrossRef

13.

Rodriguez JR, Salvia R, Crippa S, Warshaw AL, Bassi C, Falconi M, Thayer SP, Lauwers GY, Capelli P, Mino-Kenudson M, McGrath D, Pederzoli P, Fernandez-del Castillo C. Branch duct intraductal papillary mucinous neoplasms of the pancreas (IPMNs): observations in 145 resected patients. Gastroenterology 2007;133:72–79.PubMedCrossRef

14.

Jimenez RE, Warshaw AL, Z’graggen K, Hartwig W, Taylor DZ, Compton CC, Fernandez-del Castillo C. Sequential accumulation of K-ras mutations and p53 overexpression in the progression of pancreatic mucinous cystic neoplasms to malignancy. Ann Surg 1999;230:501–509; discussion 509–511.PubMedCrossRef

15.

Melotti G, Butturini G, Piccoli M, Casetti L, Bassi C, Mullineris B, Lazzaretti MG, Pederzoli P. Laparoscopic distal pancreatectomy: results on a consecutive series of 58 patients. Ann Surg 2007;246:77–82.PubMedCrossRef

16.

Hart WR. Mucinous tumors of the ovary: a review. Int J Gynecol Pathol 2005;24:4–25.PubMed

17.

Morice P, Joulie F, Camatte S, Atallah D, Rouzier R, Pautier P, Pomel C, Lhomme C, Duvillard P, Castaigne D. Lymph node involvement in epithelial ovarian cancer: analysis of 276 pelvic and paraortic lymphadenectomies and surgical implications. J Am Coll Surg 2003;197:198–205.PubMedCrossRef

18.

Crippa S, Bassi C, Warshaw AL, Falconi M, Partelli S, Thayer SP, Pederzoli P, Fernandez-del Castillo C. Middle pancreatectomy: indications, short- and long-term operative outcomes. Ann Surg 2007;246:69–76.PubMedCrossRef

Title: Mucinous Cystic Neoplasms
Author: Carlos Fernández-del Castillo
Publication date: 01-03-2008
Publisher: Springer-Verlag
Published in: Journal of Gastrointestinal Surgery / Issue 3/2008
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-007-0347-0

At a glance: The STEP trials

Springer Medicine

Mucinous Cystic Neoplasms

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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