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01-08-2021 | Magnetic Resonance Imaging | Original Article

Magnetic resonance imaging assessment of aortic dilatation and distensibility in 269 patients with repaired tetralogy of Fallot

Authors: Suvipaporn Siripornpitak, Apichaya Sriprachyakul, Saruntorn Wongmetta, Piya Samankatiwat, Pirapat Mokarapong, Suthep Wanitkun

Published in: Japanese Journal of Radiology | Issue 8/2021

Abstract

Purpose

To determine the prevalence and degree of aortic dilatation (A_dilatation), severity of aortic stiffness (A_stiff), factors for A_dilatation, and level of aortic root most sensitive to A_stiff in patients with repaired tetralogy of Fallot (rTOF).

Materials and methods

269 patients with rTOF (mean age 14.9 ± standard deviation 5.0 years) were analyzed for A_dilatation at annulus, sinus, sinotubular junction, and ascending aorta (aAo). Aortic size index was graded as Z score < 2, 2–2.99, 3–4.99 and ≥ 5. Aortic distensibility (aA_dis) was categorized according to 4 aortic levels and dilatation severity. Factors for A_dilatation and level of aortic root most sensitive to A_stiff were analyzed.

Results

Sinus and aAo were the two most common sites of A_dilatation, with a prevalence of 84% and 76%, respectively. A decreased aA_dis was found (mean 5.38 ± 1.79 10⁻³ mmHg⁻¹). aA_dis only declined significantly at the sinus level (p = 0.009). Male sex, age-at-repair and aortic regurgitation were significant factors for A_dilatation, with male sex as the strongest factor (odds ratio 2.94). There was a significant decline in aA_dis at sinus level (p = 0.002) as A_dilatation progressed.

Conclusions

We observed a high prevalence of A_dilatation and A_stiff in patients with rTOF. Male sex is the strongest factor for A_dilatation. The sinus is the most sensitive area for determining a negative aA_dis effect.

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Title: Magnetic resonance imaging assessment of aortic dilatation and distensibility in 269 patients with repaired tetralogy of Fallot
Authors: Suvipaporn Siripornpitak
Apichaya Sriprachyakul
Saruntorn Wongmetta
Piya Samankatiwat
Pirapat Mokarapong
Suthep Wanitkun
Publication date: 01-08-2021
Publisher: Springer Singapore
Keywords: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Tetralogy of Fallot
Tetralogy of Fallot
Published in: Japanese Journal of Radiology / Issue 8/2021
Print ISSN: 1867-1071
Electronic ISSN: 1867-108X
DOI: https://doi.org/10.1007/s11604-021-01119-3

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Springer Medicine

Magnetic resonance imaging assessment of aortic dilatation and distensibility in 269 patients with repaired tetralogy of Fallot

Abstract

Purpose

Materials and methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Materials and methods

Results

Conclusions

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