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01-06-2019 | Original Article

Changes in tissue gadolinium biodistribution measured in an animal model exposed to four chelating agents

Authors: Türker Acar, Egemen Kaya, Mustafa Deniz Yoruk, Neslihan Duzenli, Recep Selim Senturk, Cenk Can, Lokman Ozturk, Canberk Tomruk, Yigit Uyanikgil, Frank J. Rybicki

Published in: Japanese Journal of Radiology | Issue 6/2019

Abstract

Purpose

This study investigated the potential to reduce gadolinium levels in rodents after repetitive IV Gadodiamide administration using several chelating agents.

Materials and methods

The following six groups of rats were studied. Group 1: Control; Group 2: Gadodiamide only; Group 3: Meso-2,3-Dimercaptosuccinic acid (DMSA) + Gadodiamide; Group 4: N-Acetyl-l-cysteine (NAC) + Gadodiamide; Group 5: Coriandrum sativum extract + Gadodiamide; and Group 6: Deferoxamine + Gadodiamide. Brain, kidney, and blood samples were evaluated via inductively coupled plasma mass spectrometry. The brain was also evaluated histologically.

Results

Kidney gadolinium levels in Groups 4 and 5 were approximately double that of Group 2 (p = 0.033 for each). There was almost no calcification in rat hippocampus for Group 4 rodents when compared with Groups 2, 3, 5 and 6.

Conclusion

Our preliminary study shows that excretion to the kidney has a higher propensity in NAC and Coriandrum sativum groups. It may be possible to change the distribution of gadolinium by administrating several agents. NAC may lower Gadodiamide-induced mineralization in rat hippocampus.

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Title: Changes in tissue gadolinium biodistribution measured in an animal model exposed to four chelating agents
Authors: Türker Acar
Egemen Kaya
Mustafa Deniz Yoruk
Neslihan Duzenli
Recep Selim Senturk
Cenk Can
Lokman Ozturk
Canberk Tomruk
Yigit Uyanikgil
Frank J. Rybicki
Publication date: 01-06-2019
Publisher: Springer Japan
Published in: Japanese Journal of Radiology / Issue 6/2019
Print ISSN: 1867-1071
Electronic ISSN: 1867-108X
DOI: https://doi.org/10.1007/s11604-019-00835-1

At a glance: The STEP trials

Springer Medicine

Changes in tissue gadolinium biodistribution measured in an animal model exposed to four chelating agents

Abstract

Purpose

Materials and methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Materials and methods

Results

Conclusion

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