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Japanese Journal of Radiology
Published in: Japanese Journal of Radiology 4/2019

01-04-2019 | Scintigraphy | Original Article

Liver fibrosis assessment using 99mTc-GSA SPECT/CT fusion imaging

Authors: Ryotaro Tokorodani, Tatsuaki Sumiyoshi, Takehiro Okabayashi, Yasuhiro Hata, Yoshihiro Noda, Sojiro Morita, Hiromitsu Daisaki, Yukinori Okada, Eisuke Yasuda

Published in: Japanese Journal of Radiology | Issue 4/2019

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Abstract

Purpose

To determine the utility of mean standardized uptake value (SUVmean) of whole liver measured by 99mTc-GSA SPECT/CT fusion imaging, for evaluation of liver fibrosis.

Materials and methods

Eighty-six patients who underwent hepatectomy were enrolled, and were classified into the non-fibrosis or fibrosis group based on the pathological findings in the resected liver specimen. Univariate and multivariate analyses were performed between the two groups on four blood biochemical indices (albumin, total bilirubin, platelet count, and prothrombin time activity) and two 99mTc-GSA scintigraphy-derived liver function indices (LHL15 and SUVmean) to evaluate the independent predictive value for severe fibrosis. The diagnostic value of the index for severe fibrosis was assessed by calculating the area under the receiver operating characteristic curve.

Results

Multivariate analysis showed that prothrombin time activity [odds ratio (OR) 0.519], LHL15 (OR 0.513), and SUVmean (OR 0.168) significantly correlated with liver fibrosis. SUVmean showed the largest area under the curve, with value of 0.804, 0.730 for platelet count, 0.717 for LHL15, and 0.668 for prothrombin time activity. The optimal cut-off value for SUVmean was 6.7, which yielded 62.9% sensitivity and 96.9% specificity.

Conclusions

SUVmean measured by 99mTc-GSA SPECT/CT fusion imaging enables highly accurate prediction of severe liver fibrosis.
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Metadata
Title
Liver fibrosis assessment using 99mTc-GSA SPECT/CT fusion imaging
Authors
Ryotaro Tokorodani
Tatsuaki Sumiyoshi
Takehiro Okabayashi
Yasuhiro Hata
Yoshihiro Noda
Sojiro Morita
Hiromitsu Daisaki
Yukinori Okada
Eisuke Yasuda
Publication date
01-04-2019
Publisher
Springer Japan
Keyword
Scintigraphy
Published in
Japanese Journal of Radiology / Issue 4/2019
Print ISSN: 1867-1071
Electronic ISSN: 1867-108X
DOI
https://doi.org/10.1007/s11604-019-00810-w

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