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Published in: Japanese Journal of Radiology 12/2018

01-12-2018 | Original Article

Combined radiotherapy with nivolumab for extracranial metastatic malignant melanoma

Authors: Tetsuya Komatsu, Kenta Konishi, Masahiro Aoshima, Yoshiki Tokura, Katsumasa Nakamura

Published in: Japanese Journal of Radiology | Issue 12/2018

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Abstract

Purpose

We retrospectively evaluated the tumor regression after radiotherapy in combination with the immune checkpoint inhibitor nivolumab for metastatic melanoma.

Materials and methods

We evaluated the extracranial metastatic melanoma lesions to which concomitant radiotherapy with nivolumab was administered from June 2015 to February 2017. Tumor volume and maximum diameter were measured at the time of pre-radiotherapy and best response, and the tumor reduction rate was assessed in two ways that our hospital adopts: tumor volume and diameter.

Results

Seven lesions in five patients were evaluated. The median time from the start of nivolumab treatment to the start of radiotherapy was 5 months (range 0–22 months). The objective response rate was 85.7% in the evaluation by tumor volume and 42.9% by maximum diameter of the tumor. The objective complete response rate was 28.6% in evaluation by tumor volume and 14.3% by maximum dia. The 1-year tumor control rate was 62.5%. The 1- and 2-year overall survival rate after nivolumab treatment were 75% and 50%, respectively. Two patients who obtained a complete response had presented with vitiligo.

Conclusion

The combination of radiotherapy and nivolumab treatment produced favorable responses. Vitiligo may be correlated with a good response to concomitant radiotherapy with nivolumab.
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Metadata
Title
Combined radiotherapy with nivolumab for extracranial metastatic malignant melanoma
Authors
Tetsuya Komatsu
Kenta Konishi
Masahiro Aoshima
Yoshiki Tokura
Katsumasa Nakamura
Publication date
01-12-2018
Publisher
Springer Japan
Published in
Japanese Journal of Radiology / Issue 12/2018
Print ISSN: 1867-1071
Electronic ISSN: 1867-108X
DOI
https://doi.org/10.1007/s11604-018-0774-8

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